Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Monique D, Appelman"'
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The Farnesoid X receptor (FXR) is a nuclear receptor which is activated by bile acids. Bile acids function in solubilization of dietary fats and vitamins in the intestine. In addition, bile acids have been increasingly recognized to act as signaling
Externí odkaz:
https://doaj.org/article/2cb6d721322743489fef955174cb22a1
Publikováno v:
JHEP Reports, Vol 1, Iss 4, Pp 278-285 (2019)
Background & aims: The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimic
Externí odkaz:
https://doaj.org/article/1dc24908cee141889011cda80393ed51
Autor:
Marion J.D. Robin, Monique D. Appelman, Harmjan R. Vos, Robert M. van Es, James C. Paton, Adrienne W. Paton, Boudewijn Burgering, Peter Fickert, Jarom Heijmans, Stan F.J. van de Graaf
Publikováno v:
Hepatology Communications, Vol 2, Iss 12, Pp 1550-1566 (2018)
Cholestasis‐induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)‐mediated transcriptional down‐regulation of the bile acid importer Na+‐taurocholate cotransporting protein (NTCP) and to induction of endoplasmic
Externí odkaz:
https://doaj.org/article/cdb33609859447d8bd04980364f7430f
Autor:
Monique D. Appelman, Marion J.D. Robin, Esther W.M. Vogels, Christie Wolzak, Winnie G. Vos, Harmjan R. Vos, Robert M. Van Es, Boudewijn M.T. Burgering, Stan F.J. Van de Graaf
Publikováno v:
Cells, Vol 9, Iss 4, p 986 (2020)
The sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the basolateral membrane of hepatocytes, where it mediates the uptake of conjugated bile acids and forms the hepatocyte entry receptor for the hepatitis B and D virus. Here, we
Externí odkaz:
https://doaj.org/article/35a88ea4d6b04e51965cb87808ae33c3
Publikováno v:
Advances in experimental medicine and biology. 1390
The nuclear receptor superfamily is a group of transcriptional regulators that orchestrate multiple vital processes such as inflammation, metabolism, and cell proliferation. In recent years, it has become clear that some nuclear receptors form conden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e10b8a85b295d57e35e13e3c495976b8
https://pubmed.ncbi.nlm.nih.gov/36107323
https://pubmed.ncbi.nlm.nih.gov/36107323
Autor:
Monique D Appelman, Anindita Chakraborty, Ulrike Protzer, Jane A McKeating, Stan F J van de Graaf
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170419 (2017)
The sodium/bile acid cotransporter NTCP was recently identified as a receptor for hepatitis B virus (HBV). NTCP is glycosylated and the role of glycans in protein trafficking or viral receptor activity is not known. NTCP contains two N-linked glycosy
Externí odkaz:
https://doaj.org/article/aec617ab6d5a49679c3aeff70de4bd8e
Publikováno v:
JHEP Reports
JHEP Reports, Vol 1, Iss 4, Pp 278-285 (2019)
JHEP Reports, 1(4), 278-285. Elsevier
JHEP Reports, Vol 1, Iss 4, Pp 278-285 (2019)
JHEP Reports, 1(4), 278-285. Elsevier
Background & aims The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecb8eab783e70f28fc4c3c75718e4f6
http://europepmc.org/articles/PMC7001544
http://europepmc.org/articles/PMC7001544
Autor:
James C. Paton, Peter Fickert, Monique D. Appelman, Boudewijn M.T. Burgering, Stan F.J. van de Graaf, Adrienne W. Paton, Jarom Heijmans, Robert M. van Es, Marion J.D. Robin, Harmjan R. Vos
Publikováno v:
Hepatology communications, 2(12), 1550-1566. Wiley-Blackwell Publishing Ltd
Hepatology Communications, Vol 2, Iss 12, Pp 1550-1566 (2018)
Hepatology Communications, Vol 2, Iss 12, Pp 1550-1566 (2018)
Cholestasis‐induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)‐mediated transcriptional down‐regulation of the bile acid importer Na+‐taurocholate cotransporting protein (NTCP) and to induction of endoplasmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb9b822e8d1c844e3fedbe7c2d481e7
https://doi.org/10.1002/hep4.1262
https://doi.org/10.1002/hep4.1262
Autor:
Saskia Scheij, Cécile M. J. Ouairy, Anneke Strijland, Marri Verhoek, Monique D. Appelman, Rolf G. Boot, André Marques, D. Lahav, Mina Mirzaian, Maria J. Ferraz, Herman S. Overkleeft, Patrick Wisse, Johannes M. F. G. Aerts
Publikováno v:
FEBS letters, 590(6), 716-725. Wiley-Blackwell
Glycosphingoid bases are elevated in inherited lysosomal storage disorders with deficient activity of glycosphingolipid catabolizing glycosidases. We investigated the molecular basis of the formation of glucosylsphingosine and globotriaosylsphingosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd5a38298fa91df3dfa4e3077a1dc56
https://doi.org/10.1002/1873-3468.12104
https://doi.org/10.1002/1873-3468.12104
Autor:
Rolf G. Boot, Johannes M. F. G. Aerts, Bogdan I. Florea, Mario van der Stelt, Monique D. Appelman, Marc P. Baggelaar, Gijsbert A. van der Marel, Cécile M. J. Ouairy, Herman S. Overkleeft, Maria J. Ferraz
Publikováno v:
Chemical communications (Cambridge, England), 51(28), 6161-6163. Royal Society of Chemistry
Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b441ce710b8d55aff91113acb3715ac9
https://doi.org/10.1039/c5cc00356c
https://doi.org/10.1039/c5cc00356c