Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.

Autor: W Edward Visser, Cíntia R Bombardieri, Chantal Zevenbergen, Sander Barnhoorn, Alexandre Ottaviani, Ingrid van der Pluijm, Renata Brandt, Ellen Kaptein, Ramona van Heerebeek, Hans van Toor, George A Garinis, Robin P Peeters, Marco Medici, Willy van Ham, Wilbert P Vermeij, Monique C de Waard, Ronald R de Krijger, Anita Boelen, Joan Kwakkel, John J Kopchick, Edward O List, Joost P M Melis, Veerle M Darras, Martijn E T Dollé, Gijsbertus T J van der Horst, Jan H J Hoeijmakers, Theo J Visser

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0149941 (2016)

DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of

Externí odkaz: https://doaj.org/article/ca420b0d4f254e4db9aa43c0a8d08565

Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology.

Autor: Dick Jaarsma, Ingrid van der Pluijm, Monique C de Waard, Elize D Haasdijk, Renata Brandt, Marcel Vermeij, Yvonne Rijksen, Alex Maas, Harry van Steeg, Jan H J Hoeijmakers, Gijsbertus T J van der Horst

Publikováno v: PLoS Genetics, Vol 7, Iss 12, p e1002405 (2011)

Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neuronal degeneration and whether defects in different repair systems affect the brain differently is largely unknown. Here, we performed a systematic detail

Externí odkaz: https://doaj.org/article/aaf0ecd67093481db98f78e0db9afb1c

Early Prediction of Intensive Care Unit-Acquired Weakness

Autor: Marcus J. Schultz, Juultje Sommers, Janneke Horn, Luuk Wieske, Mengalvio E. Sleeswijk, Camiel Verhamme, Jan Jaap Spijkstra, Esther Witteveen, Monique C. de Waard, Saskia Rijkenberg, Henrik Endeman, Ivo N. van Schaik, Wouter de Ruijter

Publikováno v: Journal of intensive care medicine, 35(6), 595-605. SAGE Publications Inc.
Journal of Intensive Care Medicine, 35(6), 595-605. SAGE Publications Inc.
Journal of Intensive Care Medicine
Witteveen, E, Wieske, L, Sommers, J, Spijkstra, J J, de Waard, M C, Endeman, H, Rijkenberg, S, de Ruijter, W, Sleeswijk, M, Verhamme, C, Schultz, M J, van Schaik, I N & Horn, J 2020, ' Early Prediction of Intensive Care Unit–Acquired Weakness : A Multicenter External Validation Study ', Journal of Intensive Care Medicine, vol. 35, no. 6, pp. 595-605 . https://doi.org/10.1177/0885066618771001

Objectives: An early diagnosis of intensive care unit–acquired weakness (ICU-AW) is often not possible due to impaired consciousness. To avoid a diagnostic delay, we previously developed a prediction model, based on single-center data from 212 pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89468b57afbf62736e0c6833306e926
http://www.scopus.com/inward/record.url?scp=85080040818&partnerID=8YFLogxK

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill

Autor: Michael W. Lawlor, Maria Antonietta Pellegrino, Ger J.M. Stienen, Monique C. de Waard, Marloes van den Berg, Hieronymus W. H. van Hees, Marinus A. Paul, Albertus Beishuizen, Roberto Bottinelli, Pleuni E. Hooijman, Koen J. Hartemink, Coen A.C. Ottenheijm, Rob C. I. Wüst, Lorenza Brocca, Leo M. A. Heunks

Publikováno v: American journal of respiratory and critical care medicine, 196(12), 1544-1558. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine, 196, 12, pp. 1544-1558
Van den Berg, M, Hooijman, P E, Beishuizen, A, De Waard, M C, Paul, M A, Hartemink, K J, Van Hees, H W H, Lawlor, M W, Brocca, L, Bottinelli, R, Pellegrino, M A, Stienen, G J M, Heunks, L M A, Wüst, R C I & Ottenheijm, C A C 2017, ' Diaphragm atrophy and weakness in the absence of mitochondrial dysfunction in the critically Ill ', American Journal of Respiratory and Critical Care Medicine, vol. 196, no. 12, pp. 1544-1558 . https://doi.org/10.1164/rccm.201703-0501OC
American Journal of Respiratory and Critical Care Medicine, 196, 1544-1558
American Journal of Respiratory and Critical Care Medicine, 196(12), 1544-1558. American Thoracic Society
van den Berg, M, Hooijman, P E, Beishuizen, A, de Waard, M C, Paul, M A, Hartemink, K J, van Hees, H W H, Lawlor, M W, Brocca, L, Bottinelli, R, Pellegrino, M A, Stienen, G J M, Heunks, L M A, Wüst, R C I & Ottenheijm, C A 2017, ' Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill ', American Journal of Respiratory and Critical Care Medicine, vol. 196, no. 12, pp. 1544-1558 . https://doi.org/10.1164/rccm.201703-0501OC

RATIONALE: The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity, duration of hospital stay and health care costs. The mechanisms underlying diaphragm weaknes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95a7add77da5e7e0e1934780136e35b
https://doi.org/10.1164/rccm.201703-0501OC

Exercise Training Has Contrasting Effects in Myocardial Infarction and Pressure Overload Due to Divergent Endothelial Nitric Oxide Synthase Regulation

Autor: Dirk J. Duncker, Elza D. van Deel, Yanti Octavia, Monique C. de Waard, Martine de Boer

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 7, p 1968 (2018)
International Journal of Molecular Sciences
International journal of molecular sciences, 19(7):1968. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 19
Issue 7
International Journal of Molecular Sciences, 19(7):1968. Multidisciplinary Digital Publishing Institute (MDPI)

The beneficial effects of exercise training (EX) on cardiac pathology are well recognized. Previously, we found that the effects of EX on cardiac dysfunction in mice critically depend on the underlying etiology. EX exerted beneficial effects after my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995bd0fff58c81a51d74aa50a010e5b2
https://doi.org/10.3390/ijms19071968