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pro vyhledávání: '"Monique C P Mendonça"'
Autor:
Monique C. P. Mendonça, Yao Sun, Michael F. Cronin, Andrew J. Lindsay, John F. Cryan, Caitriona M. O’Driscoll
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 520 (2023)
Huntington’s disease (HD) is a progressive inherited neurodegenerative disease caused by a CAG repeat expansion in the huntingtin gene, which is translated into the pathologic mutant huntingtin (mHTT) protein. Despite the great potential of HTT low
Externí odkaz:
https://doaj.org/article/33618e036dd34f8ebede77e2c30a28d4
Autor:
Ayse Kont, Monique C. P. Mendonça, Michael F. Cronin, Mary R. Cahill, Caitriona M. O’Driscoll
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9791 (2022)
Non-viral delivery of therapeutic nucleic acids (NA), including siRNA, has potential in the treatment of diseases with high unmet clinical needs such as acute myeloid leukaemia (AML). While cationic biomaterials are frequently used to complex the nuc
Externí odkaz:
https://doaj.org/article/0c40ee09d4f64884a651297553e6a88e
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 169:309-318
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene, leading to a toxic version of the HTT protein. There are currently no disease-modifying therapies available. In this scenario, gene-based tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede74dfb816ced4638ae70541abc3598
https://doi.org/10.1016/j.ejpb.2021.11.003
https://doi.org/10.1016/j.ejpb.2021.11.003
Autor:
Monique C. P. Mendonça, Cintia Rizoli, Daiana S. Ávila, Mónica J. B. Amorim, Marcelo B. de Jesus
Publikováno v:
Frontiers in Environmental Science, Vol 5 (2017)
Over the last decade, engineered nanomaterials (NMs) brought a revolutionary development in many sectors of human life including electronics, paints, textiles, food, agriculture, and health care. However, the exponential growth in the number of NMs a
Externí odkaz:
https://doaj.org/article/7752d6709632455dae9d0ccab4a251e4
Publikováno v:
Nanomaterials, Vol 9, Iss 6, p 858 (2019)
Graphene-based nanomaterials (GBNs) possess unique physicochemical properties, allowing a wide range of applications in physical, chemical, and biomedical fields. Although GBNs are broadly used, information about their adverse effects on ecosystem he
Externí odkaz:
https://doaj.org/article/0142daf055914f37920e9cd2d6914dbc
Autor:
Monique C. P. Mendonça, Edilene S. Soares, Leila M. Stávale, Catarina Rapôso, Andressa Coope, Evanguedes Kalapothakis, Maria Alice da Cruz-Höfling
Publikováno v:
Toxins, Vol 5, Iss 12, Pp 2572-2588 (2013)
Apart from its angiogenic and vascular permeation activity, the vascular endothelial growth factor (VEGF) has been also reported as a potent neuronal protector. Newborn rats with low VEGF levels develop neuron degeneration, while high levels induce p
Externí odkaz:
https://doaj.org/article/92b5e456573c487b80c1ed2d138cfa0b
Autor:
Ayse Kont, María Rodríguez Aburto, John F. Cryan, Monique C P Mendonça, Caitriona M. O'Driscoll
RNA-based therapeutics have emerged as one of the most powerful therapeutic options used for the modulation of gene/protein expression and gene editing with the potential to treat neurodegenerative diseases. However, the delivery of nucleic acids to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72047a25862fee7b1f89ab5065f801c
https://hdl.handle.net/10468/12068
https://hdl.handle.net/10468/12068
Autor:
Edilene S. Soares, Leila M. Stávale, Monique C. P. Mendonça, Andressa Coope, Maria Alice da Cruz-Höfling
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 11, p 1462 (2016)
We have previously demonstrated that Phoneutria nigriventer venom (PNV) causes blood–brain barrier (BBB) breakdown, swelling of astrocytes end-feet and fluid permeation into brain interstitium in rats. Caveolae and water channels respond to BBB alt
Externí odkaz:
https://doaj.org/article/6af5dc5d4d1743a7960f27a5f36eb280