Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Monique Breton-Douillon"'
1
Phosphoinositide 3-kinases and their role in inflammation: potential clinical targets in atherosclerosis?
Autor: Nicole Malet, Muriel Laffargue, Fabienne Briand-Mesange, Anne Fougerat, Monique Breton-Douillon, Stéphanie Gayral
Publikováno v: Clinical Science. 116:791-804
Inflammation has a central role in the pathogenesis of atherosclerosis at various stages of the disease. Therefore it appears of great interest to develop novel and innovative drugs targeting inflammatory proteins for the treatment of atherosclerosis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86feab9be45713ae091a373f5baaffeb
https://doi.org/10.1042/cs20080549
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2
SHIP-2 and PTEN Are Expressed and Active in Vascular Smooth Muscle Cell Nuclei, but Only SHIP-2 Is Associated with Nuclear Speckles
Autor: Jean-Pierre Salles, Bertrand Perret, Laurent Carrez, Daniel Bacqueville, Paul Déléris, Monique Breton-Douillon, Stéphanie Gayral
Publikováno v: Journal of Biological Chemistry. 278:38884-38891
Recently, the control of phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3)-dependant signaling by phosphatases has emerged, but there is a shortage of information on intranuclear PtdIns(3,4,5)P3 phosphatases. Therefore, we investigated the d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c9f7d6b32c4a089095caf42f8534fa
https://doi.org/10.1074/jbc.m300816200
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3
Phosphatidylinositol 3-Kinase Inhibitors Block Aortic Smooth Muscle Cell Proliferation in Mid-Late G1 Phase: Effect on Cyclin-Dependent Kinase 2 and the Inhibitory Protein p27KIP1
Autor: Bertrand Perret, Monique Breton-Douillon, Daniel Bacqueville, Hugues Chap, Fabrice Casagrande, Jean-Marie Darbon
Publikováno v: Biochemical and Biophysical Research Communications. 244:630-636
In the present study, we investigated the involvement of phosphatidylinositol 3-kinase (PI 3-kinase) activity in the progression of vascular smooth muscle cells (VSMCs) throughout the G1 phase of cell cycle. Addition of two selective inhibitors of PI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8a35d18b96b566c320deba6254f76d
https://doi.org/10.1006/bbrc.1997.7885
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4
Stimulation of phosphoinositide thrombin is restricted to the platelets kinases by plasma membrane in
Autor: Borchert Gh, Claire Racaud-Sultan, Monique Breton-Douillon, Monique Plantavid, Gérard Mauco, Hugues Chap
Publikováno v: Platelets. 9:97-102
This study was based on the hypothesis that lipid kinases in the different subcellular fractions would be differently affected by thrombin-treatment of platelets prior to subcellular fractionation. When using our previously reported method for subcel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6caad0d03a154583749d9c8565c257a
https://doi.org/10.1080/09537109876861
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5
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes
Autor: Bertrand Perret, Emilio Hirsch, Matthias Schwarz, Matthias P. Wymann, Stéphanie Gayral, Alexia Schambourg, Pierre Gourdy, Monique Breton-Douillon, Jean-François Arnal, Jean-Pierre Salles, Christian Rommel, Muriel Laffargue, Thomas Rückle, Anne Fougerat
Publikováno v: Circulation
Circulation, American Heart Association, 2008, 117 (10), pp.1310-7. ⟨10.1161/CIRCULATIONAHA.107.720466⟩
Background— The role of inflammation at all stages of the atherosclerotic process has become an active area of investigation, and there is a notable quest for novel and innovative drugs for the treatment of atherosclerosis. The lipid kinase phospho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fe65e26aeb24bb8a838c23422a6a0e
https://pubmed.ncbi.nlm.nih.gov/18268153
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6
Selective activation of nuclear phospholipase D-1 by g protein-coupled receptor agonists in vascular smooth muscle cells
Autor: Bertrand Perret, Karine Laulagnier, Monique Breton-Douillon, Muriel Laffargue, Stéphanie Gayral, Michel Record, Jean-Pierre Salles, Paul Déléris
Publikováno v: Circulation research. 99(2)
Recent studies highlight the existence of an autonomous nuclear lipid metabolism related to cellular proliferation. However, the importance of nuclear phosphatidylcholine (PC) metabolism is poorly understood. Therefore, we were interested in nuclear
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de662aa75cf43abd75cf601ce4dfd52
https://pubmed.ncbi.nlm.nih.gov/16857971
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7
Nuclear Ptdlns(3,4,5)P3 signaling: an ongoing story
Autor: Stéphanie Gayral, Monique Breton-Douillon, Paul Déléris
Publikováno v: Journal of cellular biochemistry. 98(3)
Phosphatidylinositol 3,4,5-trisphosphate (Ptdlns(3,4,5)P(3)) is linked to a variety of cellular functions, such as growth, cell survival, and differentiation. Ptdlns(3,4,5)P(3) is primarily synthesized by class I phosphoinositide 3-kinases and its hy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9103b3f94d7843590ff5547ad47431ff
https://pubmed.ncbi.nlm.nih.gov/16645993
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8
Characterization of a G protein-activated phosphoinositide 3-kinase in vascular smooth muscle cell nuclei
Autor: Christiane Mendre, Daniel Bacqueville, Hugues Chap, Paul Déléris, Gilles Guillon, Bertrand Perret, Pieraggi Mt, Monique Breton-Douillon
Publikováno v: The Journal of biological chemistry. 276(25)
Recent studies highlight the existence of an autonomous nuclear polyphosphoinositide metabolism related to cellular proliferation and differentiation. However, only few data document the nuclear production of the putative second messengers, the 3-pho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f664ee68b7899f842c95a33a05a8f42
https://pubmed.ncbi.nlm.nih.gov/11303021
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9
Lipid Products of Phosphoinositide 3-Kinase and Phosphatidylinositol 4,5-Bisphosphate Are Both Required for ADP-dependent Platelet Spreading*
Autor: Bertrand Perret, Daisy Gironcel, Séverine Roques, Thierry Giacomini, Jean-Michel Heraud, Corinne Albiges-Rizo, Hugues Chap, Monique Breton-Douillon, Claire Racaud-Sultan, Véronique Martel
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1998, 273 (28), pp.17817-23. ⟨10.1074/jbc.273.28.17817⟩
Journal of Biological Chemistry, 1998, 273 (28), pp.17817-23. ⟨10.1074/jbc.273.28.17817⟩
International audience; We have shown previously that ADP released upon platelet adhesion mediated by IIb 3 integrin triggers accumulation of phosphatidylinositol 3,4-bisphosphate (PtdIns-3,4-P 2) (Gironcel, D., Racaud-Sultan, C., Payras-tre, B., Har
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b794153785e381e8be9b33099eddaae
https://hal-riip.archives-ouvertes.fr/pasteur-01676555
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10
Calpains are involved in phosphatidylinositol 3',4'-bisphosphate synthesis dependent on the alpha IIb beta 3 integrin engagement in thrombin-stimulated platelets
Autor: Hugues Chap, Claire Racaud-Sultan, Bernard Payrastre, Monique Plantavid, Gérard Mauco, Monique Breton-Douillon, Nathalie Montsarrat
Publikováno v: FEBS letters. 404(1)
In thrombin-stimulated platelets αIIbβ3 integrin engagement triggers both phosphatidylinositol 3′,4′-bisphosphate synthesis and calpain activation. We checked the possible involvement of calpains in phosphatidylinositol 3-kinase signalling path
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852b42c9f4b02ff2d2c180eb60dfa96b
https://pubmed.ncbi.nlm.nih.gov/9074630
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