Site-directed mutagenesis of Mycobacterium tuberculosis and functional validation to investigate potential bedaquiline resistance-causing mutations

Autor: Christian C. Otum, Emmanuel Rivière, Monique Barnard, Johannes Loubser, Monique J. Williams, Elizabeth M. Streicher, Annelies Van Rie, Robin M. Warren, Marisa Klopper

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Molecular detection of bedaquiline resistant tuberculosis is challenging as only a small proportion of mutations in candidate bedaquiline resistance genes have been statistically associated with phenotypic resistance. We introduced two mutat

Externí odkaz: https://doaj.org/article/ae71f361f4b04dd4ba76f7495f679496

Towards equity: a retrospective analysis of public sector radiological resources and utilization patterns in the metropolitan and rural areas of the Western Cape Province of South Africa in 2017

Autor: Richard D. Pitcher, Beulah Christina van Zyl, Michelle Monique Barnard, Keith Cloete, Amanda Fernandez, Matodzi Mukosi

Publikováno v: BMC Health Services Research, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Health Services Research

BackgroundThe reduction of inequality is a key United Nations 2030 Sustainable Development Goal (WHO, Human Resources for Health: foundation for Universal Health Coverage and the post-2015 development agenda, 2014; Transforming our world: the 2030 Ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3be8bd4dffb908de5bfbd5e97d6a2c
https://doaj.org/article/b4196320ca1a4b1d9f5545d25e83c912

Public Sector Radiological Resources and Utilization Patterns in the Western Cape Province of South Africa

Autor: Beulah Christina van Zyl, Michelle Monique Barnard, Amanda Fernandez, Keith Cloete, Matodzi Mukosi, Richard Denys Pitcher

Background There are marked disparities in radiological resources globally, particularly between metropolitan and rural populations. The World Health Organization (WHO) suggests that 90% of low- and middle-income country (LMIC) imaging needs can be a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a6c15a5f7d62702d24764b2fccdc711
https://doi.org/10.21203/rs.3.rs-89229/v1

11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): Implications for castration resistant prostate cancer

Autor: Elzette Pretorius, Karl-Heinz Storbeck, Jacky L. Snoep, Elahe A. Mostaghel, Jonathan L. Quanson, Monique Barnard

Publikováno v: Journal of Steroid Biochemistry and Molecular Biology, 183, 192-201. Elsevier Limited
Barnard, M, Quanson, J L, Mostaghel, E, Pretorius, E, Snoep, J L & Storbeck, K H 2018, ' 11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3) : Implications for castration resistant prostate cancer ', Journal of Steroid Biochemistry and Molecular Biology, vol. 183, pp. 192-201 . https://doi.org/10.1016/j.jsbmb.2018.06.013

The progression of castration resistant prostate cancer (CRPC) is driven by the intratumoral conversion of adrenal androgen precursors to potent androgens. The expression of aldo-keto reductase 1C3 (AKR1C3), which catalyses the reduction of weak andr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef2ccbf0104b2a854dcbfbb102fe8b4
https://research.vu.nl/en/publications/992c3306-8364-41ac-8e30-5d29ce85b064