Identification of Hypoxia-response Element in the Human Endothelial Nitric-oxide Synthase Gene Promoter

Autor: Sophie Nadaud, Florent Soubrier, Monique Agrapart, Florence Coulet

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2003, 278 (47), pp.46230-46240. ⟨10.1074/jbc.M305420200⟩

The human endothelial nitric-oxide synthase gene (heNOS) is constitutively expressed in endothelial cells, and its expression is induced under hypoxia. The goal of this study was to search for regulatory elements of the endothelial nitric-oxide synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84a06d8870bcf5c1d008f0b0266b853
https://doi.org/10.1074/jbc.m305420200

Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function

Autor: Sonia‐Athina Karabina, Isabelle Brochériou, Gilles Le Naour, Monique Agrapart, Hervé Durand, Michael Gelb, Gérard Lambeau, Ewa Ninio

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2006, 20 (14), pp.2547-9. ⟨10.1096/fj.06-6018fje⟩
FASEB Journal, 2006, 20 (14), pp.2547-9. ⟨10.1096/fj.06-6018fje⟩

Increasing evidence suggests that secreted phospholipases A2 (sPLA2s) play an important role in the pathophysiology of atherosclerosis. Among sPLA2s, the human group X (hGX) enzyme has the highest catalytic activity toward phosphatidylcholine, one of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c2a092c13c0d9a88a9190ba3a3b129
https://hal.archives-ouvertes.fr/hal-00170587

Characterization of an Upstream Enhancer Region in the Promoter of the Human Endothelial Nitric-oxide Synthase Gene

Autor: Florent Soubrier, Yves Laumonnier, Monique Agrapart, Sophie Nadaud

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2000, 275 (52), pp.40732-40741. ⟨10.1074/jbc.M004696200⟩

The endothelial nitric-oxide synthase gene is constitutively expressed in endothelial cells. Several transcriptionally active regulatory elements have been identified in the proximal promoter, including a GATA-2 and an Sp-1 binding site. Because they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1991a53d0ec4cbc00379691026f76a
https://hal.science/hal-03783621

Induction of angiotensin I-converting enzyme transcription by a protein kinase C-dependent mechanism in human endothelial cells

Autor: Florent Soubrier, Monique Agrapart, M. Challah, Amalia Alonso, Eric Villard

Publikováno v: The Journal of biological chemistry. 273(39)

Angiotensin I-converting enzyme (ACE) has been implicated in various cardiovascular diseases; however, little is known about the ACE gene regulation in endothelial cells. We have investigated the effect of the protein kinase C activator phorbol 12-my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f0539eb95f5c250a8228e1d2eeb8c5
https://pubmed.ncbi.nlm.nih.gov/9737980

Parasite-derived mitogenic activity for human T cells in Plasmodium falciparum continuous cultures

Autor: M A Querleux, C Schmitt, Pierre Druilhe, Monique Agrapart, Ballet Jj

Publikováno v: Infection and Immunity. 33:758-762

Supernatants from Plasmodium falciparum continuous cultures exhibited mitogenic activity against human blood lymphocytes from unsensitized donors. This effect, which was not observed with supernatants from control cultures grown in the absence of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780c60588a720fd34d08111fc92eaf80
https://doi.org/10.1128/iai.33.3.758-762.1981