Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

Autor: Thiago M. Cunha, Lucas Esteves Cardozo, Florêncio Figueiredo, Konstantina Lyroni, Emilio Hirsch, F. N. Gava, João Santana da Silva, Edecio Cunha-Neto, Renata Sesti-Costa, Christophe Chevillard, Carla D. Lopes, Maria R. C. da Silva, Marcela Davoli-Ferreira, Christos Tsatsanis, José C. Alves-Filho, Fernando Q. Cunha, Fabrício C. Dias, Helder I. Nakaya, Monique Andrade Baron, Amanda Farage Frade, Tiago Medina, Grace K. Silva

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-03986-3⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), 〈10.1038/s41467-018-03986-3〉
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi (T. cruzi) and is an important cause of severe inflammatory heart disease. However, the mechanisms driving Chagas disease cardiomyopathy have not been completely elucidated. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680a767d00256eee5e6ff23ff5d0026e
https://doi.org/10.1038/s41467-018-03986-3

Whole-Genome Cardiac DNA Methylation Fingerprint and Gene Expression Analysis Provide New Insights in the Pathogenesis of Chronic Chagas Disease Cardiomyopathy

Autor: Laurie, Laugier, Amanda Farage, Frade, Frederico Moraes, Ferreira, Monique Andrade, Baron, Priscila Camillo, Teixeira, Sandrine, Cabantous, Ludmila Rodrigues Pinto, Ferreira, Laurence, Louis, Vagner Oliveira Carvalho, Rigaud, Fabio Antônio, Gaiotto, Fernando, Bacal, Pablo, Pomerantzeff, Edimar, Bocchi, Jorge, Kalil, Ronaldo Honorato Barros, Santos, Edecio, Cunha-Neto, Christophe, Chevillard

Publikováno v: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

Summary DNA methylation analysis on global gene expression in myocardial samples from patients with end-stage chronic Chagas cardiomyopathy leads to the identification of novel potential disease pathways and therapeutic targets linked to electrical c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f94e3618d29302751ac8c220a5c7a347
https://pubmed.ncbi.nlm.nih.gov/28575239

Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

Autor: Jorge Kalil, Sandrine Cabantous, Pablo Maria Alberto Pomerantzeff, Christophe Chevillard, Ronaldo Honorato Barros Santos, Isabela Cunha Navarro, Monique Andrade Baron, Priscila Camillo Teixeira, Ludmila Rodrigues Pinto Ferreira, Luiz Alberto Benvenuti, Fernando Bacal, Laurie Laugier, Amanda Farage Frade, Fábio Antônio Gaiotto, Darlan da Silva Cândido, Frederico Moraes Ferreira, Edecio Cunha-Neto

Publikováno v: The Journal of infectious diseases. 214(1)

Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e7174ad18262377cf175f1b16ee5e8
https://pubmed.ncbi.nlm.nih.gov/26951817

Functional IL18 polymorphism and susceptibility to Chronic Chagas Disease

Autor: Ariana de Melo Borges, Virmondes Rodrigues, Monique Andrade Baron, Cristina Wide Pissetti, Christophe Chevillard, Hui-Tzu Lin Wang, Mario Hiroyuki Hirata, Abílio Fragata, Jorge Kalil, Mariana M Lensi, Charles Mady, Marcelo Ferraz Sampaio, Bruno Saba, Eduardo Antônio Donadi, Gisele de Lima Peixoto, Luciana Gabriel Nogueira, Sandrine Cabantous, José Antonio Marin-Neto, Martino Martinelli, André Schmidt, Paula Buck, Sérgio Siqueira, Laurie Laugier, Amanda Farage Frade, Alexandre C. Pereira, Fabrício Moura Dias, Edecio Cunha-Neto, Barbara Maria Ianni

Publikováno v: Cytokine
Cytokine, 2015, 73 (1), pp.79-83
Cytokine, Elsevier, 2015, 73 (1), pp.79-83
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background Chronic Chagas Disease cardiomyopathy (CCC), a life-threatening inflammatory dilated cardiomyopathy, affects 30% of the approximately 8 million patients infected by Trypanosoma cruzi, the rest of the infected subjects remaining asymptomati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d35e1255d999e9968a380a577283a3
https://hal-amu.archives-ouvertes.fr/hal-01592692

Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions

Autor: Jorge Kalil, Monique Andrade Baron, Isabela Cunha Navarro, L. C. J. Abel, Luiz Vicente Rizzo, Ludmila Rodrigues Pinto Ferreira, Ricardo T. Gazzinelli, Edecio Cunha-Neto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Mediators of Inflammation, Vol 2014 (2014)
Mediators of Inflammation

Chagas disease, caused by the protozoan parasiteTrypanosoma cruzi(T. cruzi), is characterized by immunopathology driven by IFN-γsecreting Th1-like T cells.T. cruzihas a thick coat of mucin-like glycoproteins covering its surface, which plays an impo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1107ac104b98c475fe576c85f47b729