Loss of sodium chloride co-transporter impairs the outgrowth of the renal distal convoluted tubule during renal development

Autor: Christina Schnoz, Johannes Loffing, Monique Carrel

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 35(3)

Background Loss-of-function mutations in the sodium chloride (NaCl) co-transporter (NCC) of the renal distal convoluted tubule (DCT) cause Gitelman syndrome with hypokalemic alkalosis, hypomagnesemia and hypocalciuria. Since Gitelman patients are usu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ed70802efa7f8a98dd6cbb081ff0c8
https://pubmed.ncbi.nlm.nih.gov/31436795

Extracellular K(+) rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl(-) -dependent and independent mechanisms

Autor: Johannes Loffing, Dominique Loffing-Cueni, Nina Himmerkus, Olivier Staub, Frank Schweda, David Penton, Jan Czogalla, Monique Carrel, Markus Bleich, Renuga Devi Rajaram, Agnieszka Wengi

Publikováno v: The Journal of Physiology, vol. 594, no. 21, pp. 6319-6331

High dietary potassium (K(+) ) intake dephosphorylates and inactivates the NaCl cotransporter (NCC) in the renal distal convoluted tubule (DCT). Using several ex vivo models, we show that physiological changes in extracellular K(+) , similar to those

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44f6915985d738e3718e311dff08b6a
https://serval.unil.ch/resource/serval:BIB_2310FFAA834D.P001/REF.pdf

Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension

Autor: Johannes Loffing, Monique Carrel, Nicolas Picard, R. Lance Miller, Robert A. Fenton, David H. Ellison, Chao Ling Yang, Katja Trompf, Dominique Loffing-Cueni

Publikováno v: Picard, N, Trompf, K, Yang, C-L, Miller, R L, Carrel, M, Loffing-Cueni, D, Fenton, R A, Ellison, D H & Loffing, J 2013, ' Protein Phosphatase 1 Inhibitor-1 Deficiency Reduces Phosphorylation of Renal NaCl Cotransporter and Causes Arterial Hypotension ', Journal of the American Society of Nephrology . https://doi.org/10.1681/ASN.2012121202
Journal of the American Society of Nephrology

The thiazide-sensitive NaCl cotransporter (NCC) of the renal distal convoluted tubule (DCT) controls ion homeostasis and arterial BP. Loss-of-function mutations of NCC cause renal salt wasting with arterial hypotension (Gitelman syndrome). Conversely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e273abf4e26eea7ef8ffe4c308cfe2a7
https://pubmed.ncbi.nlm.nih.gov/24231659

Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension

Autor: Monique Carrel, Johannes Loffing, Sara Damiano, Maria Rosaria Rizzo, Markus Paulmichl, Maria Lisa Garavaglia, Miriam Zacchia, Patrizia Ferrari, Giuliano Meyer, Giuseppe Bianchi, Alessandra Mugione, Carsten A. Wagner, Giovambattista Capasso, Florian Lang, Francesco Trepiccione

Publikováno v: Capasso, G, Rizzo, M, Garavaglia, M L, Trepiccione, F, Zacchia, M, Mugione, A, Ferrari, P, Paulmichl, M, Lang, F, Loffing, J, Carrel, M, Damiano, S, Wagner, C A, Bianchi, G & Meyer, G 2008, ' Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension ', American Journal of Physiology: Renal Physiology, vol. 295, no. 2, pp. F556-67 . https://doi.org/10.1152/ajprenal.00340.2007

We investigated which of the NaCl transporters are involved in the maintenance of salt-sensitive hypertension. Milan hypertensive (MHS) rats were studied 3 mo after birth. In MHS, compared with normotensive strain (MNS), mRNA abundance, quantified by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f28537be399932b97b28b157e3e22db
https://www.zora.uzh.ch/id/eprint/5020/