First-Line Treatment for Advanced Hepatocellular Carcinoma: A Three-Armed Real-World Comparison

Autor: Mahn R, Glüer OA, Sadeghlar F, Möhring C, Zhou T, Anhalt T, Monin MB, Kania A, Glowka TR, Feldmann G, Brossart P, Kalff JC, Schmidt-Wolf IGH, Strassburg CP, Gonzalez-Carmona MA

Publikováno v: Journal of Hepatocellular Carcinoma, Vol Volume 11, Pp 81-94 (2024)

Robert Mahn,1,* Oscar André Glüer,1,* Farsaneh Sadeghlar,1 Christian Möhring,1 Taotao Zhou,1 Thomas Anhalt,1 Malte Benedikt Monin,1 Alexander Kania,2 Tim R Glowka,2 Georg Feldmann,3 Peter Brossart,3 Joerg C Kalff,2 Ingo GH Schmidt-Wolf,4 C

Externí odkaz: https://doaj.org/article/7b0e6b47d2314e87ba683eca85fb6ff5

Early combination therapy of COVID-19 in high-risk patients.

Autor: Orth HM; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Flasshove C; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Berger M; Institute for Medical Biometry, Informatics and Epidemiology, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany., Hattenhauer T; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Oncology, Hematology, Rheumatology and Immune-Oncology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Biederbick KD; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Oncology, Hematology, Rheumatology and Immune-Oncology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Mispelbaum R; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Oncology, Hematology, Rheumatology and Immune-Oncology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Klein U; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Oncology, Hematology, Rheumatology and Immune-Oncology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Stemler J; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department I of Internal Medicine, European Diamond Excellence Centre for Medical Mycology (ECMM), University of Cologne, Faculty of Medicine, and University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Institute of Translational Research, Cologne Excellence Cluster On Cellular Stress Responses, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; German Centre for Infection Research (DZIF), Partner-Site Cologne-Bonn, Kerpener Str. 62, 50937, Cologne, Germany., Fisahn M; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department I of Internal Medicine, European Diamond Excellence Centre for Medical Mycology (ECMM), University of Cologne, Faculty of Medicine, and University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Institute of Translational Research, Cologne Excellence Cluster On Cellular Stress Responses, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; German Centre for Infection Research (DZIF), Partner-Site Cologne-Bonn, Kerpener Str. 62, 50937, Cologne, Germany., Doleschall AD; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany., Baermann BN; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Hematology, Oncology, and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Koenigshausen E; Department of Nephrology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Tselikmann O; Department of Nephrology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Killer A; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., de Angelis C; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Gliga S; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Stegbauer J; Department of Nephrology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Spuck N; Institute for Medical Biometry, Informatics and Epidemiology, Bonn University Hospital, Venusberg-Campus 1, 53127, Bonn, Germany., Silling G; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany., Rockstroh JK; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Centre for Infection Research (DZIF), Partner-Site Cologne-Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Strassburg CP; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Brossart P; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Oncology, Hematology, Rheumatology and Immune-Oncology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Panse JP; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany., Jensen BO; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Luedde T; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany., Boesecke C; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Centre for Infection Research (DZIF), Partner-Site Cologne-Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Heine A; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department of Oncology, Hematology, Rheumatology and Immune-Oncology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Cornely OA; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany.; Department I of Internal Medicine, European Diamond Excellence Centre for Medical Mycology (ECMM), University of Cologne, Faculty of Medicine, and University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Institute of Translational Research, Cologne Excellence Cluster On Cellular Stress Responses, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; German Centre for Infection Research (DZIF), Partner-Site Cologne-Bonn, Kerpener Str. 62, 50937, Cologne, Germany., Monin MB; Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf, (ABCD), Aachen, Germany. malte_benedikt.monin@ukbonn.de.; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. malte_benedikt.monin@ukbonn.de.; German Centre for Infection Research (DZIF), Partner-Site Cologne-Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. malte_benedikt.monin@ukbonn.de.; Johanniter-Kliniken Bonn GmbH, Johanniter-Krankenhaus Bonn, Bonn, Germany. malte_benedikt.monin@ukbonn.de.

Publikováno v: Infection [Infection] 2024 Jun; Vol. 52 (3), pp. 877-889. Date of Electronic Publication: 2023 Nov 29.

Antiviral treatment of COVID-19: which role can clinical parameters play in therapy evaluation?

Autor: Hübner YR; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Spuck N; Faculty of Medicine, Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany., Berger M; Faculty of Medicine, Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany., Schlabe S; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany., Rieke GJ; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany., Breitschwerdt S; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany., van Bremen K; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany., Strassburg CP; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Gonzalez-Carmona MA; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Wasmuth JC; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany., Rockstroh JK; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany., Boesecke C; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany., Monin MB; Department of Internal Medicine I, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. malte_benedikt.monin@ukbonn.de.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany. malte_benedikt.monin@ukbonn.de.

Publikováno v: Infection [Infection] 2023 Dec; Vol. 51 (6), pp. 1855-1861. Date of Electronic Publication: 2023 Aug 09.

Enabling CAR T-cell therapies for HIV-positive lymphoma patients - A call for action.

Autor: Hattenhauer ST; Department of Oncology, Hematology, Rheumatology and Immune-Oncology, University Hospital Bonn, Bonn, Germany., Mispelbaum R; Department of Oncology, Hematology, Rheumatology and Immune-Oncology, University Hospital Bonn, Bonn, Germany., Hentrich M; Department of Internal Medicine III, Red Cross Hospital Munich, Munich, Germany., Boesecke C; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany., Monin MB; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; German Centre for Infection Research (DZIF), partner-site Cologne-Bonn, Bonn, Germany.

Publikováno v: HIV medicine [HIV Med] 2023 Sep; Vol. 24 (9), pp. 957-964. Date of Electronic Publication: 2023 Jun 15.

Impaired immunogenicity after vaccination for SARS-CoV-2 in patients with gastrointestinal cancer: does tumor entity matter?

Autor: Monin MB; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany., Gorny JG; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Berger M; Institute for Medical Biometry, Informatics and Epidemiology, Bonn University Hospital, Bonn, Germany., Baier LI; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Zhou T; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Mahn R; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Sadeghlar F; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Möhring C; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Boesecke C; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany., van Bremen K; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany., Rieke GJ; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany., Schlabe S; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany., Breitschwerdt S; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; German Centre for Infection Research (DZIF), Partner-site Cologne-Bonn, Bonn, Germany., Marinova M; Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany., Schmidt-Wolf IGH; Department of Integrated Oncology, Center for Integrated Oncology (CIO), University Hospital Bonn, Bonn, Germany., Strassburg CP; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Eis-Hübinger AM; Institute of Virology, Bonn University Hospital, Bonn, Germany., Gonzalez-Carmona MA; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.

Publikováno v: Journal of gastrointestinal oncology [J Gastrointest Oncol] 2023 Jun 30; Vol. 14 (3), pp. 1218-1234. Date of Electronic Publication: 2023 Jun 26.