Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Monika Witzenberger"'
Autor:
Marlon S. Zambrano-Mila, Monika Witzenberger, Zohar Rosenwasser, Anna Uzonyi, Ronit Nir, Shay Ben-Aroya, Erez Y. Levanon, Schraga Schwartz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and/or ADAR2 at varying levels, raising the question of what are the determinants guiding substrate specificity and how these differ between the two enzymes. We moni
Externí odkaz:
https://doaj.org/article/4c2d499ad67e4af4a9e51a00babc91cd
Autor:
Michael A Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Jonas Metz, Pardes Habib, Sabri E.M. Sahnoun, Carina Sobisch, Benedetta Poma, Oscar Palomino-Hernandez, Mirko Wagner, Thomas Carell, N. Jon Shah, Jörg B. Schulz, Dierk Niessing, Aaron Voigt, Giulia Rossetti
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 443-458 (2022)
Polyglutamine (polyQ) diseases are characterized by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats encoding for an uninterrupted prolonged polyQ tract. We previously identified TRMT2A as a strong modifier of polyQ-induced toxici
Externí odkaz:
https://doaj.org/article/b64bb5ae313246c5aac74fe4b11f4b6c
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
Autor:
Pessah Yampolsky, Michael Koenen, Matias Mosqueira, Pascal Geschwill, Sebastian Nauck, Monika Witzenberger, Claudia Seyler, Thomas Fink, Mathieu Kruska, Claus Bruehl, Alexander P. Schwoerer, Heimo Ehmke, Rainer H. A. Fink, Andreas Draguhn, Dierk Thomas, Hugo A. Katus, Patrick A. Schweizer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The depolarizing funny current contributing to cardiac pacemaking is upregulated in the myocardium of failing and infarcted hearts, but whether the current is implied in disease mechanisms is unclear. Here the authors generate HCN4 transgenic mice an
Externí odkaz:
https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c74
Autor:
Monika Witzenberger, Sandra Burczyk, Luisa M. Welp, Mirko Wagner, Thomas Monecke, Robert Janowski, Thomas Carell, Henning Urlaub, Stefanie M. Hauck, Aaron Voigt, Dierk Niessing
Methyl-5-uridine (m5U) is one of the most abundant RNA modifications found in cytosolic tRNA. tRNA methyltransferase 2 homolog A (hTRMT2A) is the dedicated mammalian enzyme of m5U conversion at tRNA position 54. However, its RNA binding specificity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01d3629f511f1fe029c0df61487d70bf
https://doi.org/10.1101/2022.12.28.522094
https://doi.org/10.1101/2022.12.28.522094
Autor:
Michael A Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Jonas Metz, Pardes Habib, Sabri E.M. Sahnoun, Carina Sobisch, Benedetta Poma, Oscar Palomino-Hernandez, Mirko Wagner, Thomas Carell, N. Jon Shah, Jörg B. Schulz, Dierk Niessing, Aaron Voigt, Giulia Rossetti
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and structural biotechnology journal 20, 443-458 (2022). doi:10.1016/j.csbj.2021.12.029
Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 443-458 (2022)
Comp. Struc. Biotech. J. 20, 443-458 (2022)
Computational and structural biotechnology journal 20, 443-458 (2022). doi:10.1016/j.csbj.2021.12.029
Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 443-458 (2022)
Comp. Struc. Biotech. J. 20, 443-458 (2022)
Graphical abstract
Polyglutamine (polyQ) diseases are characterized by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats encoding for an uninterrupted prolonged polyQ tract. We previously identified TRMT2A as a strong modifier
Polyglutamine (polyQ) diseases are characterized by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats encoding for an uninterrupted prolonged polyQ tract. We previously identified TRMT2A as a strong modifier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15677489121bc9c362f0f135ce56ba5
https://pubmed.ncbi.nlm.nih.gov/35070167
https://pubmed.ncbi.nlm.nih.gov/35070167
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
Autor:
Hugo A. Katus, Matias Mosqueira, Pascal Geschwill, Claudia Seyler, Rainer H. A. Fink, Dierk Thomas, Pessah Yampolsky, Monika Witzenberger, Michael Koenen, Thomas Fink, Patrick A. Schweizer, Mathieu Kruska, Sebastian Nauck, Claus Bruehl, Andreas Draguhn, Heimo Ehmke, Alexander P. Schwoerer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
HCN channels underlie the depolarizing funny current (If) that contributes importantly to cardiac pacemaking. If is upregulated in failing and infarcted hearts, but its implication in disease mechanisms remained unresolved. We generated transgenic mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224a1eea9f8d27759558602018201304
https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c74
https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c74
Autor:
Zambrano-Mila, Marlon S., Witzenberger, Monika, Rosenwasser, Zohar, Uzonyi, Anna, Nir, Ronit, Ben-Aroya, Shay, Levanon, Erez Y., Schwartz, Schraga
Publikováno v:
Nature Communications; 12/11/2023, Vol. 14 Issue 1, p1-14, 14p
Autor:
Yampolsky, Pessah, Koenen, Michael, Mosqueira, Matias, Geschwill, Pascal, Nauck, Sebastian, Witzenberger, Monika, Seyler, Claudia, Fink, Thomas, Kruska, Mathieu, Bruehl, Claus, Schwoerer, Alexander P., Ehmke, Heimo, Fink, Rainer H. A., Draguhn, Andreas, Thomas, Dierk, Katus, Hugo A., Schweizer, Patrick A.
Publikováno v:
Nature Communications; 7/23/2019, Vol. 10 Issue 1, pN.PAG-N.PAG, 1p