Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Monika Wierdl"'
Autor:
Andrew C. Hemmert, Tamara C. Otto, Roberto A. Chica, Monika Wierdl, Jonathan S. Edwards, Steven M. Lewis, Carol C. Edwards, Lyudmila Tsurkan, C. Linn Cadieux, Shane A. Kasten, John R. Cashman, Stephen L. Mayo, Philip M. Potter, Douglas M. Cerasoli, Matthew R. Redinbo
Publikováno v:
PLoS ONE, Vol 7, Iss 1 (2012)
Externí odkaz:
https://doaj.org/article/48227b2df6724d49b81ec197ceefeed0
Autor:
Andrew C Hemmert, Tamara C Otto, Roberto A Chica, Monika Wierdl, Jonathan S Edwards, Steven M Lewis, Carol C Edwards, Lyudmila Tsurkan, C Linn Cadieux, Shane A Kasten, John R Cashman, Stephen L Mayo, Philip M Potter, Douglas M Cerasoli, Matthew R Redinbo
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17441 (2011)
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poison
Externí odkaz:
https://doaj.org/article/cc3673771a9c4824bb65ae97a1dd1a81
Publikováno v:
British Journal of Pharmacology. 173:2811-2818
Carboxylesterases (CEs) are ubiquitous enzymes responsible for the detoxification of ester-containing xenobiotics. This hydrolysis reaction results in the formation of the corresponding carboxylic acid and alcohol. Due to their highly plastic active
Autor:
Monika Wierdl, Cori Bradley, Chunxu Qu, Philip M. Potter, M. Jason Hatfield, Xiang Chen, Viktor Tollemar, Lyudmila Tsurkan, Liying Chi
PURPOSE: The anaplastic lymphoma kinase (ALK) has been demonstrated to be a valid clinical target in diseases such as anaplastic large cell lymphoma and non-small cell lung cancer. Recent studies have indicated that ALK is overexpressed in pediatric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d5cdce45e239548270d953b666f143
https://europepmc.org/articles/PMC6054567/
https://europepmc.org/articles/PMC6054567/
Autor:
James R. Downing, Jianmin Wang, Walter H. Lang, Fred Krafcik, Michael Rusch, Kristy Boggs, Matthew Parker, Michael N. Edmonson, Nilsa C. Ramirez, Lei Wei, Steve Skapek, Li Ding, Anang A. Shelat, Justina McEvoy, Sara M. Federico, Elaine R. Mardis, Sheila A. Shurtleff, Jinghui Zhang, Heather L. Mulder, John A. Sandoval, Lyudmila Tsurkan, Andrew M. Davidoff, Viktor Tolleman, Charles Lu, Gang Wu, Chunxu Qu, Sheri L. Spunt, Cori Bradley, Panduka Nagahawatte, Elizabeth Stewart, Douglas S. Hawkins, Marcus B. Valentine, Richard K. Wilson, Philip M. Potter, Donald Yergeau, Xiang Chen, David Finkelstein, Monika Wierdl, Erin Hedlund, John Easton, Armita Bahrami, Virginia Valentine, Mark E. Hatley, Alberto S. Pappo, Christopher L. Morton, Michael A. Dyer
Publikováno v:
Cancer Cell. 24:710-724
SummaryRhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic featu
Autor:
Monika Wierdl, Carol C. Edwards, Lyudmila Tsurkan, Michael R. Taylor, Janice L. Hyatt, Robyn A. Umans, Philip M. Potter, M. Jason Hatfield
Publikováno v:
Chemico-biological interactions. 259
Carboxylesterases (CE) are members of the esterase family of enzymes, and as their name suggests, they are responsible for the hydrolysis of carboxylesters into the corresponding alcohol and carboxylic acid. To date, no endogenous CE substrates have
Autor:
Randy M. Wadkins, Xiaozhen Yu, Steven R. Gwaltney, Philip M. Potter, Delwar Hossain, Sara C. Sigler, Monika Wierdl
Publikováno v:
Journal of Molecular Modeling. 18:2869-2883
Carboxylesterases (CEs) are ubiquitous enzymes responsible for the detoxification of xenobiotics. In humans, substrates for these enzymes are far-ranging, and include the street drug heroin and the anticancer agent irinotecan. Hence, their ability to
Autor:
Andrew C. Hemmert, John R. Cashman, Monika Wierdl, Mary MacDonald, Matthew R. Redinbo, Christopher D. Fleming, Douglas M. Cerasoli, Philip M. Potter, Tamara C. Otto, Carol C. Edwards
Publikováno v:
Molecular Pharmacology. 77:508-516
Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholinergic crisis. Development of protein-based therapeutics is being pursued with the goal of preventing nerve agent toxicity and prote
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 4:1153-1165
Background: Carboxylesterases (CEs) are ubiquitous enzymes responsible for the hydrolysis of numerous clinically useful drugs. As ester moieties are frequently included in molecules to improve their water solubility and bioavailability, de facto they
Autor:
Lyudmila Tsurkan, Carol C. Edwards, Monika Wierdl, Antonio M. Ferreira, Janice L. Hyatt, Latorya D. Hicks, Teri Moak, Philip M. Potter, Randy M. Wadkins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3801-3817
We have synthesized and assessed the ability of symmetrical fluorobenzoins and fluorobenzils to inhibit mammalian carboxylesterases (CE). The majority of the latter were excellent inhibitors of CEs however unexpectedly, the fluorobenzoins were very g