Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Monika Wielechowska"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1991 (2023)
CK2 and PIM-1 are serine/threonine kinases involved in the regulation of many essential processes, such as proliferation, differentiation, and apoptosis. Inhibition of CK2 and PIM-1 kinase activity has been shown to significantly reduce the viability
Externí odkaz:
https://doaj.org/article/5bf2af62e00946f984da40f3b8f62d61
Autor:
Konrad Chojnacki, Patrycja Wińska, Olena Karatsai, Mirosława Koronkiewicz, Małgorzata Milner-Krawczyk, Monika Wielechowska, Maria Jolanta Rędowicz, Maria Bretner, Paweł Borowiecki
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6261 (2021)
Protein kinase CK2 has been considered as an attractive drug target for anti-cancer therapy. The synthesis of N-hydroxypropyl TBBi and 2MeTBBi derivatives as well as their respective esters was carried out by using chemoenzymatic methods. Concomitant
Externí odkaz:
https://doaj.org/article/4034e2fe881a44e8842d6a457885ffd2
Publikováno v:
ARKIVOC, Vol 2012, Iss 8, Pp 262-281 (2012)
Externí odkaz:
https://doaj.org/article/f34363985cc74899ac011a3ac67d9c91
Autor:
Elżbieta Senkara, Dominik Cysewski, Paweł Wilamowski, Joanna Cieśla, Monika Wielechowska, Maria Bretner, Patrycja Wińska, Katarzyna Skierka
Publikováno v:
Biochemical and Biophysical Research Communications. 513:368-373
Dihydrofolate reductase (DHFR) is a prominent molecular target in antitumor, antibacterial, antiprotozoan, and immunosuppressive chemotherapies, and CK2 protein kinase is an ubiquitous enzyme involved in many processes, such as tRNA and rRNA synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724d0ca9899c35bac64eb463325cc1ca
https://doi.org/10.1016/j.bbrc.2019.03.186
https://doi.org/10.1016/j.bbrc.2019.03.186
Autor:
Monika Wielechowska, K. Chojnacki, Maria Bretner, Paweł Borowiecki, Maria Jolanta Redowicz, Mirosława Koronkiewicz, Olena Karatsai, Małgorzata Milner-Krawczyk, Patrycja Wińska
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6261, p 6261 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences
Volume 22
Issue 12
Protein kinase CK2 has been considered as an attractive drug target for anti-cancer therapy. The synthesis of N-hydroxypropyl TBBi and 2MeTBBi derivatives as well as their respective esters was carried out by using chemoenzymatic methods. Concomitant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ea9fb0e8302bf255163d909e20116e
https://pubmed.ncbi.nlm.nih.gov/34200807
https://pubmed.ncbi.nlm.nih.gov/34200807
Autor:
Ewa Mironiuk-Puchalska, Jolanta Ignatowska, Maria Bretner, Mariola Koszytkowska-Stawińska, Piotr Grześkowiak, Patrycja Wińska, Monika Wielechowska, Olena Karatsai, Maria Jolanta Redowicz
Publikováno v:
Bioorganic Chemistry
Three series of the β-pyrimidine alanines, including willardiine - a naturally occurring amino acid, were prepared from the l -serine-derived sulfamidates. Compounds 3b, 4a and 4b demonstrated antiproliferative activity toward the studied cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33438ac10ee5e1c3842f269f2225c55f
Publikováno v:
European Journal of Organic Chemistry. 2018:763-771
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bbd1311d9b3589689b2d0145f6971c7
https://doi.org/10.1002/ejoc.201701512
https://doi.org/10.1002/ejoc.201701512
Autor:
D. Lindenblatt, Christine Toelzer, Maria Bretner, Patrycja Wińska, K. Chojnacki, Karsten Niefind, Monika Wielechowska
Publikováno v:
Bioorganic Chemistry. 106:104502
The new halogenated 1H-triazolo[4,5-b]pyridines and 1H-imidazo[4,5-b]pyridines were synthesised as analogues of known CK2 inhibitors: 4,5,6,7-tetrabromo-1H-benzotriazole (TBBt) and 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi). Their influence on the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a406ac0de793f16fbe0600f21aac0e72
https://doi.org/10.1016/j.bioorg.2020.104502
https://doi.org/10.1016/j.bioorg.2020.104502
Autor:
Monika Wielechowska, Karolina Chreptowicz, Jolanta Mierzejewska, E. Rybak, Joanna Główczyk-Zubek
Publikováno v:
Food and Bioproducts Processing. 100:275-281
2-Phenylethanol (2-PE) is a volatile substance widely used in food, fragrance and cosmetics industries. Nowadays, most 2-PE originates from chemical synthesis. Since there is an increasing demand for natural products, we designed an alternative metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::443a2ca5c84c616714e2961426217d47
https://doi.org/10.1016/j.fbp.2016.07.011
https://doi.org/10.1016/j.fbp.2016.07.011
Autor:
Maciej Malinowski, Patrycja Guzik, Wojciech Sas, Anna Sobiepanek, Monika Wielechowska, Tomasz Rowicki
Publikováno v:
European Journal of Organic Chemistry. 2016:3642-3649
An exceptionally short synthesis of novel indolizidine-, quinolizidine-, and piperidine-based iminosugars from unprotected 2-deoxy-d-ribose by intramolecular 1,3-dipolar cycloaddition of sugar-derived N-(3-alkenyl)nitrones has been accomplished. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7425333fcbba3178453dbb7f5d3cd1e
https://doi.org/10.1002/ejoc.201600459
https://doi.org/10.1002/ejoc.201600459