Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Monika Tocchi"'
Autor:
Illimar Altosaar, Jelica Mehic, Fiona A. Prior, Suzanne Porter, Margaret Bell, Monika Tocchi, Peter R. Ganz, Ravinder Sardana, Eilleen S. Tackaberry, Anil K. Dudani
Publikováno v:
Genome. 46:521-526
The use of transgenic plants in the production of recombinant proteins for human therapy, including subunit vaccines, is being investigated to evaluate the efficacy and safety of these emerging biopharmaceutical products. We have previously shown tha
CD40 ligand preferentially modulates immune response and enhances protection against influenza virus
Autor:
Alexander Pereboev, Junzhi Wang, Caroline Gravel, Xuguang Li, Monika Tocchi, Xingliang Fan, Yinglei Yi, Changgui Li, Michael Rosu-Myles, Anwar M. Hashem, Ze Chen, Runtao He, Bozena Jaentschke
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 193(2)
CD40L, a key regulator of the immune system, was studied as both a targeting ligand and a molecular adjuvant in nucleoprotein (NP)-based host defense against influenza in mouse models with different genetic backgrounds. Adenoviral vectors secreting N
Autor:
Runtao He, Caroline Gravel, Anwar M. Hashem, Tracey M. Doyle, Bozena Jaentschke, Xuguang Li, Monika Tocchi, Michael Rosu-Myles
Publikováno v:
Human vaccinesimmunotherapeutics. 8(4)
Current influenza vaccines mainly induce strain-specific neutralizing antibodies and need to be updated each year, resulting in significant burdens on vaccine manufacturers and regulatory agencies. Genetic immunization strategies based on the highly
Publikováno v:
Toxicology and applied pharmacology. 253(2)
Interferon α (IFNα) is used to treat malignancies and chronic viral infections. It has been found to decrease the rate of drug metabolism by acting on cytochrome P450 enzymes, but no studies have investigated the consequences of IFNα treatment on
Publikováno v:
Environmental Health Perspectives
Di(2-ethylhexyl)phthalate (DEHP), the plasticizer used in the biomedical production of blood storage bags, hemodialysis systems, cardiopulmonary bypass (CPB) circuitry, and intubation tubes, is extracted from the plastic material when it comes into c
Publikováno v:
Toxicology and Applied Pharmacology. 106:48-52
Di(2-ethylhexyl)phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC)-derived plastic. Mono(2-ethylhexyl)phthalate (MEHP), the major metabolite of DEHP, had a reversible, concentration-dependent (15-200 micrograms/ml) negative in
Autor:
Monika Tocchi, Nikolay Korokhov, David T. Curiel, Louise Larocque, Xuguang Li, D Huang, Wangxue Chen, Bozena Jaentschke, Alexander Pereboev, Caroline Gravel, W L Casley, Runtao He, M Lemieux
Publikováno v:
Gene Therapy
CD40 ligation has been shown to promote antigen-presenting functions of dendritic cells, which express CD40 receptor. Here we reported significantly altered biodistribution and immune responses with the use of CD40-targeted adenovirus. Compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940df4dbf64d6690de73b7c731e215ae
https://doi.org/10.1038/sj.gt.3303085
https://doi.org/10.1038/sj.gt.3303085
Autor:
Fiona A. Prior, Jelica Mehic, Suzanne Porter, Illimar Altosaar, Karen Rowlandson, Anil K. Dudani, Mark R. Schleiss, P. R. Ganz, Mike Walsh, Monika Tocchi, Ravinder Sardana, Eilleen S. Tackaberry
Publikováno v:
Molecular biotechnology. 40(1)
Production of recombinant subunit vaccines in transgenic plants may be a means of reducing vaccine costs while increasing availability and safety. A plant-derived product found safe and effective for oral administration would provide additional advan
Autor:
Anwar Hashem, Caroline Gravel, Monika Tocchi, Bozena Jaentschke, Xingliang Fan, Ze Chen, Changgui Li, Wang Junzhi, Xuguang Li
Publikováno v:
The Journal of Immunology. 192:72.5-72.5
Influenza nucleoprotein is a highly conserved antigen and a candidate universal vaccine against flu. However, NP-based vaccines can only afford weak protective immunity compared to HA. Using CD40 ligand (CD40L), a key regulator of the immune system,
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 97:900-905
Di(2-ethylhexyl)phthalate and its principal metabolite, mono(2-ethylhexyl)phthalate, are contaminants of blood that are extracted on contact with polyvinylchloride surfaces, such as blood collection bags and tubing used in cardiopulmonary bypass. In