Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Monika Rella"'
Autor:
Gemma Victoria White, Duncan S. Holmes, Monika Rella, James H. Thorpe, Robert J. Young, Ann Louise Walker, Kathrine J. Smith, Emma V. Edgar, Alain Hovnanian, Oxana Polyakova, Ryan P. Bingham, Yichen Wang, Alan R. Ferrie, John Liddle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1454-1458
The connection between Netherton syndrome and overactivation of epidermal/dermal proteases particularly KLK5 has been well established. To treat sufferers of this severe condition we wished to develop a topical KLK5 inhibitor in order to normalise ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb70e7bcff67aff90d0df8eac3790560
https://doi.org/10.1016/j.bmcl.2019.04.022
https://doi.org/10.1016/j.bmcl.2019.04.022
Autor:
Alain Hovnanian, Gemma Victoria White, Andrew C. Pearce, Duncan S. Holmes, Ann Louise Walker, James H. Thorpe, Oxana Polyakova, Monika Rella, Emma V. Edgar, Xiao Qing Lewell, Yichen Wang, Kathrine J. Smith, John Liddle, Pamela Nassau
Publikováno v:
Acta Crystallogr F Struct Biol Commun
The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b904d6e32f37f3f2060eb5adea3aacfd
https://europepmc.org/articles/PMC6497096/
https://europepmc.org/articles/PMC6497096/
Autor:
Richard M. Jackson, Jerry Lanfear, Nigel M. Hooper, Monika Rella, Timothy J. Revett, Anne Phelan, Joann L Elliot, Anthony J. Turner
Publikováno v:
BMC Genomics
BMC Genomics, Vol 8, Iss 1, p 194 (2007)
BMC Genomics, Vol 8, Iss 1, p 194 (2007)
Background Mammalian angiotensin converting enzyme (ACE) plays a key role in blood pressure regulation. Although multiple ACE-like proteins exist in non-mammalian organisms, to date only one other ACE homologue, ACE2, has been identified in mammals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5f485658965dd7863217f74cd9e38f
Autor:
Neil A. R. Gow, Serena Selvaggini, Rhian Whitton, H. Bleddyn Hughes, Carol A. Munro, Monika Rella
Publikováno v:
Fungal genetics and biology : FGB. 40(2)
In silico analysis of the genome sequence of the human pathogenic fungus Candida albicans identified an open reading frame encoding a putative fourth member of the chitin synthase gene family. This gene, named Ca CHS8 , encodes an 1105 amino acid ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53eef479fb8e4f8f97bbffdb18522745
https://pubmed.ncbi.nlm.nih.gov/14516767
https://pubmed.ncbi.nlm.nih.gov/14516767
Autor:
Monika Rella
Publikováno v:
Journal of the American Chemical Society. 133:17101-17102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cac9fefa2c6dd4dc57b41973526bf48
https://doi.org/10.1021/ja208498e
https://doi.org/10.1021/ja208498e
Autor:
Monika Rella
Publikováno v:
Drug Discovery Today. 10:375
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c5c2533659c374370b527ca10b861ea
https://doi.org/10.1016/s1359-6446(05)03397-0
https://doi.org/10.1016/s1359-6446(05)03397-0
Autor:
David Edward Clark, Monika Rella
Publikováno v:
Drug Discovery Today. 10:77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92249da798ef576499b440e96abf81aa
https://doi.org/10.1016/s1359-6446(04)03348-3
https://doi.org/10.1016/s1359-6446(04)03348-3