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Akademický článek

AntagomiR-103 and -107 Treatment Affects Cardiac Function and Metabolism

Autor: Monika Rech, Annika R. Kuhn, Joost Lumens, Paolo Carai, Rick van Leeuwen, Wouter Verhesen, Robin Verjans, Julie Lecomte, Yilin Liu, Joost J.F.P. Luiken, Ronny Mohren, Berta Cillero-Pastor, Stephane Heymans, Kèvin Knoops, Marc van Bilsen, Blanche Schroen

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 424-437 (2019)

MicroRNA-103/107 regulate systemic glucose metabolism and insulin sensitivity. For this reason, inhibitory strategies for these microRNAs are currently being tested in clinical trials. Given the high metabolic demands of the heart and the abundant ca

Externí odkaz: https://doaj.org/article/03f5c125b05442e58d0707ee557c3fae

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Akademický článek

Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.

Autor: Chris McDermott-Roe, Marion Leleu, Glenn C Rowe, Oleg Palygin, John D Bukowy, Judy Kuo, Monika Rech, Steffie Hermans-Beijnsberger, Sebastian Schaefer, Eleonora Adami, Esther E Creemers, Matthias Heinig, Blanche Schroen, Zoltan Arany, Enrico Petretto, Aron M Geurts

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0170458 (2017)

Mitochondrial dysfunction contributes to myriad monogenic and complex pathologies. To understand the underlying mechanisms, it is essential to define the full complement of proteins that modulate mitochondrial function. To identify such proteins, we

Externí odkaz: https://doaj.org/article/32ee4dc91d374bd4874942d7b45e8553

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AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism

Autor: Yilin Liu, Joost J. F. P. Luiken, Wouter Verhesen, Joost Lumens, Kèvin Knoops, Julie Lecomte, Monika Rech, Blanche Schroen, Ronny Mohren, Berta Cillero-Pastor, Paolo Carai, Stephane Heymans, Rick van Leeuwen, Marc van Bilsen, Robin Verjans, Annika R. Kuhn

Publikováno v: Molecular Therapy-Nucleic Acids, 14, 424-437. Cell Press
Molecular Therapy: Nucleic Acids, Vol 14, Iss, Pp 424-437 (2019)
Molecular Therapy. Nucleic Acids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e16330d713229d471abbb5000e1f57b
https://cris.maastrichtuniversity.nl/en/publications/97b4b62d-6daf-4769-906d-b96698bbbed9

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Assessing fatty acid oxidation flux in rodent cardiomyocyte models

Autor: Miranda Nabben, Joost J. F. P. Luiken, M. van Bilsen, Monika Rech, Jan F. C. Glatz, Blanche Schroen

Publikováno v: Scientific Reports
Scientific Reports, 8:1505. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)

The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements are crucial to investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe97353807d824a118d9f73f8c483bd
https://www.nature.com/articles/s41598-018-19478-9.pdf

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Insulin Receptor Substrates Are Essential for the Bioenergetic and Hypertrophic Response of the Heart to Exercise Training

Autor: Yi Zhu, E. Dale Abel, Tenley A. Rawlings, Annie Seixas Bello Moreira, Christian Riehle, Bharat P. Jaishy, Jack Bevins, Rajkumar Manivel, Jung Hyun Noh, Eric T. Weatherford, Adam R. Wende, Renata O. Pereira, Karen Jesus Oliveira, Monika Rech, Morris F. White, Steven Valdez, Bum Jun Kim

Publikováno v: Molecular and Cellular Biology. 34:3450-3460

Insulin and insulin-like growth factor 1 (IGF-1) receptor signaling pathways differentially modulate cardiac growth under resting conditions and following exercise training. These effects are mediated by insulin receptor substrate 1 (IRS1) and IRS2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4b7e7624b9ddfda338c1e91d779e96
https://doi.org/10.1128/mcb.00426-14

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Insulin receptor substrate signaling suppresses neonatal autophagy in the heart

Autor: Sandra Sena, Morris F. White, Xiaoming Sheng, Monika Rech, Christian Riehle, Steven Valdez, Adam R. Wende, Renata O. Pereira, Jack Bevins, Xiaocheng C. Dong, Heiko Bugger, Karla Maria Pereira Pires, Dong Chen, Deborah U. Frank, Evan Dale Abel, Yi Zhu, Bart C. Weimer, Cynthia N. Perry, Roberta A. Gottlieb

Publikováno v: The Journal of clinical investigation, vol 123, iss 12

The induction of autophagy in the mammalian heart during the perinatal period is an essential adaptation required to survive early neonatal starvation; however, the mechanisms that mediate autophagy suppression once feeding is established are not kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3659326d59c2158ea8aa3cb7d16b2139
https://doi.org/10.1172/jci71171

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Abstract 81: Absence of Macrophage microRNA-155 Affects Cardiac Metabolic and Inflammatory Remodeling Following Diabesotension and Protects Against Development of Heart Failure

Autor: Nicole Bitsch, Marc van Bilsen, Stephane Heymans, Kristiaan Wouters, Monika Rech, Blanche Schroen, Julie Lecomte

Publikováno v: Circulation Research. 119

The co-existence of diabetes, obesity, hypertension - diabesotension - is a major burden in western societies and often culminates into heart failure (HF). Diabesotension is associated with a chronic status of low-grade inflammation, involving macrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f15de8e3045b5394d55014e22b842cb
https://doi.org/10.1161/res.119.suppl_1.81

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Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function

Autor: Judy Kuo, Esther E. Creemers, Glenn C. Rowe, Zoltan Arany, Eleonora Adami, John D. Bukowy, Marion Leleu, Oleg Palygin, Enrico Petretto, Matthias Heinig, Monika Rech, Chris McDermott-Roe, Aron M. Geurts, Steffie Hermans-Beijnsberger, Blanche Schroen, Sebastian Schaefer

Publikováno v: Europe PubMed Central
PLoS ONE
PLOS ONE, 12(2):0170458. Public Library of Science
PLoS ONE, 12(2):e0170458. Public Library of Science
PLoS ONE 12:e0170458 (2017)
PLoS ONE, Vol 12, Iss 2, p e0170458 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c7fc2bf1931aba4468033cd841db5a
https://doi.org/10.1371/journal.pone.0170458

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P69The microRNA-221/222 family is differentially regulated in cardiac disease and counteracts pressure overload-induced cardiac remodeling in mice

Autor: Wouter J. A. Derks, Tim Peters, L. J. de Windt, Stephane Heymans, R Van Leeuwen, Blanche Schroen, Mitchell Bijnen, Monika Rech

Publikováno v: Cardiovascular Research. 103:S11.3-S11

Purpose: Despite major advances in the treatment of cardiovascular diseases, heart failure (HF) remains one of the top causes of death world-wide. The implications of microRNAs in this process are well accepted but still only incompletely understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22f694ad11613995ffff0819ccf60ca1
https://doi.org/10.1093/cvr/cvu082.13

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