Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Monika Raab"'
Autor:
Monika Raab, Izabela Kostova, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Seyed Mohsen Aberoumandi, Evelyn Ullrich, Sven Becker, Mourad Sanhaji, Klaus Strebhardt
Publikováno v:
Cancer Communications, Vol 44, Iss 1, Pp 101-126 (2024)
Abstract Background The cellular tumor protein p53 (TP53) is a tumor suppressor gene that is frequently mutated in human cancers. Among various cancer types, the very aggressive high‐grade serous ovarian carcinoma (HGSOC) exhibits the highest preva
Externí odkaz:
https://doaj.org/article/cdcbdaaef4af4c5cad1851cbfb3a4e85
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T-cell activation is a complex process involving a network of kinases and downstream molecular scaffolds or adaptors that integrate surface signals with effector functions. One key immune-specific adaptor is Src kinase-associated phosphoprotein 1 (SK
Externí odkaz:
https://doaj.org/article/4e98e2eee1b1411f841d15412e47181c
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Activation of T cells in the tumor microenvironment can be inhibited through a variety of mechanisms. Here, the authors show that Rasal1, a GTPase-activating protein, binds and inhibits signaling downstream of the T Cell Receptor complex and that con
Externí odkaz:
https://doaj.org/article/5e3f7af3677d4cc6984ba9564955a165
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract While the immune cell adaptor protein SKAP1 mediates LFA-1 activation induced by antigen-receptor (TCR/CD3) ligation on T-cells, it is unclear whether the adaptor interacts with other mediators of T-cell function. In this context, the serine
Externí odkaz:
https://doaj.org/article/b50da4e16a664a14a971d8a9772fdbb6
Autor:
Monika Raab, Mourad Sanhaji, Shengtao Zhou, Franz Rödel, Ahmed El-Balat, Sven Becker, Klaus Strebhardt
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 4, Pp 363-375 (2019)
Paclitaxel is a frontline drug for the treatment of epithelial ovarian cancer (EOC). However, following paclitaxel-platinum based chemotherapy, tumor recurrence occurs in most ovarian cancer patients. Chromosomal instability (CIN) is a hallmark of ca
Externí odkaz:
https://doaj.org/article/8a22921e22854a7892573ef4c3da59b1
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018)
Abstract Objective Immune cell adaptor protein SKAP1 couples the antigen-receptor (TCR/CD3) with the activation of LFA-1 adhesion in T-cells. Previous work by ourselves and others have shown that SKAP1 can directly bind to other adaptors such as ADAP
Externí odkaz:
https://doaj.org/article/12221994293d47f7924ee5903410045f
Autor:
Franz Rödel, Shengtao Zhou, Balász Győrffy, Monika Raab, Mourad Sanhaji, Ranadip Mandal, Daniel Martin, Sven Becker, Klaus Strebhardt
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Since type and duration of an appropriate adjuvant chemotherapy in early-stage ovarian cancer (OC) are still being debated, novel markers for a better stratification of these patients are of utmost importance for the design of an improved chemotherap
Externí odkaz:
https://doaj.org/article/93cf63b38a824a33a0f7a987b5777ec1
Autor:
Monika Raab, Mourad Sanhaji, Yves Matthess, Albrecht Hörlin, Ioana Lorenz, Christina Dötsch, Nils Habbe, Oliver Waidmann, Elisabeth Kurunci-Csacsko, Ron Firestein, Sven Becker, Klaus Strebhardt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The overexpression of Polo-like kinase 1 (Plk1) promotes various cancers in humans; sporadic evidence suggests Plk1 could act as a tumor suppressor but the molecular basis for this effect are unclear. Here the authors show that Plk1 inhibition augmen
Externí odkaz:
https://doaj.org/article/a03432a0fac04ac49c63a7cf0e5451dc
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of th
Externí odkaz:
https://doaj.org/article/4c73c60958e443bda720387ec3ccab2c
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 6 (2018)
Adenomatous polyposis coli (APC) mutations cause aneuploidy and are responsible for familial adenomatous polyposis characterized by chromosomal instability. PLK1 contributes to sustain an intact spindle assembly checkpoint ensuring genomic stability.
Externí odkaz:
https://doaj.org/article/112a07dec6c340d6b918fd62a3fbb27c