Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Monika Poláková"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 282-293 (2023)
A synthesis of 1,4-imino-ᴅ-lyxitols and their N-arylalkyl derivatives altered at C-5 is reported. Their inhibitory activity and selectivity toward four GH38 α-mannosidases (two Golgi types: GMIIb from Drosophila melanogaster and AMAN-2 from Caenor
Externí odkaz:
https://doaj.org/article/82908c4ffdea4294b3fd64371df93220
Publikováno v:
Molecules, Vol 28, Iss 6, p 2516 (2023)
Paenibacillus larvae is the causative agent of American foulbrood (AFB), the most serious bacterial disease affecting developing honeybee larvae and pupas. In this study, a library of 24 (thio)glycosides, glycosyl sulfones, 6-O-esters, and ethers der
Externí odkaz:
https://doaj.org/article/f5d286426e4a4bb0b403717215562c47
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2156-2162 (2018)
A synthetic approach to 1,4-imino-L-lyxitols with various modifications at the C-5 position is reported. These imino-L-lyxitol cores were used for the preparation of a series of N-(4-halobenzyl)polyhydroxypyrrolidines. An impact of the C-5 modificati
Externí odkaz:
https://doaj.org/article/40bf1218cf6c44b2a1f2b14752387ecb
Autor:
Mária Mastihubová, Monika Poláková
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 524-530 (2016)
Several bioactive natural p-hydroxyphenylalkyl β-D-glucopyranosides, such as vanillyl β-D-glucopyranoside, salidroside and isoconiferin, and their glycosyl analogues were prepared by a simple reaction sequence. The highly efficient synthetic approa
Externí odkaz:
https://doaj.org/article/b6b74128bce54093a6384fe1187fec8f
Publikováno v:
ChemBioChem. 24
Publikováno v:
Organic & Biomolecular Chemistry. 20:8932-8943
A binding mechanism of selective inhibitors of Golgi α-mannosidase II was elucidated by pKa and FMO-PIEDA calculations. Synthetic N-substituted imino-d-lyxitol inhibitors were evaluated with four enzymes from the glycoside hydrolase GH38 family.
Publikováno v:
New Journal of Chemistry. 45:10940-10951
N-Alkylated 1,4-dideoxy-1,4-imino-L-lyxitols (N-alkylated polyhydroxypyrrolidines) differing in the alkyl chain length (from C7 to C14) and their capping functional group (methyl, amine, amidine and guanidine) have been synthesized. Based on molecula
Publikováno v:
Bioorganic Chemistry. 83:424-431
Inhibition of the biosynthesis of complex N-glycans in the Golgi apparatus is one of alternative ways to suppress growth of tumor tissue. Eight N-benzyl substituted 1,4-imino- l -lyxitols with basic functional groups (amine, amidine, guanidine), hydr
Publikováno v:
Journal of Molecular Structure. 1177:16-25
A synthetic approach to novel 2-(1-glycosyl-1,2,3-triazol-4-yl)-3-hydroxyquinolone conjugates has been developed. The methodology involves preparation of a suitable quinoline intermediate and its subsequent conjugation with various acylated glycosyl
Recombinant luciferase-expressing murine gammaherpesvirus 68 as a tool for rapid antiviral screening
Publikováno v:
Acta virologica. 63:439-449
Murine gammaherpesvirus 68 (MHV-68) provides a valuable tool to screen novel therapeutic strategies against oncogenic gammaherpesviruses. The development and characterization of antiviral agents usually depend on appropriate screening assays. The aim