Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Monika Pawlik"'
Autor:
Pasquale D’Acunzo, Elentina K. Argyrousi, Jonathan M. Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N. Goulbourne, Ottavio Arancio, Efrat Levy
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer’s disease, in Down syndrome, and in mouse models of these conditions. We have previously shown
Externí odkaz:
https://doaj.org/article/152d303abcc5498582c312cac72d05ac
Autor:
Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens, Ralph A. Nixon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show in an animal model and in a study in patients with dementia with Lewy bodies (DLB) that the drug neflamapimod has potential to treat diseases, such as DLB, associated with loss of neurons that produce the neurotransmitter acetylcholi
Externí odkaz:
https://doaj.org/article/435994d00b734e18a90ea82931cd1bac
Autor:
Pasquale D'Acunzo, Jonathan M. Ungania, Yohan Kim, Bryana R. Barreto, Steven DeRosa, Monika Pawlik, Stefanie Canals‐Baker, Hediye Erdjument‐Bromage, Audrey Hashim, Chris N. Goulbourne, Thomas A. Neubert, Mariko Saito, Henry Sershen, Efrat Levy
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 1, Pp n/a-n/a (2023)
Abstract Cocaine, an addictive psychostimulant, has a broad mechanism of action, including the induction of a wide range of alterations in brain metabolism and mitochondrial homeostasis. Our group recently identified a subpopulation of non‐microves
Externí odkaz:
https://doaj.org/article/ef1beae90ae14629ba8533a2a1dcee1e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The widespread occurrence of litter is a severe threat to global ecosystems. We have analyzed online media, to assess the diversity of animals that are prone to getting trapped in discarded containers and check which kind of containers is th
Externí odkaz:
https://doaj.org/article/95927172ce554113bce755e2fbffd8c1
Autor:
Gurjinder Kaur, Sebastien A. Gauthier, Rocio Perez-Gonzalez, Monika Pawlik, Amol Bikram Singh, Benjamin Cosby, Panaiyur S. Mohan, John F. Smiley, Efrat Levy
Publikováno v:
Neurobiology of Disease, Vol 120, Iss , Pp 165-173 (2018)
Cystatin C (CysC) plays diverse protective roles under conditions of neuronal challenge. We investigated whether CysC protects from trisomy-induced pathologies in a mouse model of Down syndrome (DS), the most common cause of developmental cognitive a
Externí odkaz:
https://doaj.org/article/3d9f1c007e374667b978464f23656cc0
Autor:
Jan Gajewski, Magdalena Garbacz, Chih-Wei Chang, Katarzyna Czerska, Marco Durante, Nils Krah, Katarzyna Krzempek, Renata Kopeć, Liyong Lin, Natalia Mojżeszek, Vincenzo Patera, Monika Pawlik-Niedzwiecka, Ilaria Rinaldi, Marzena Rydygier, Elzbieta Pluta, Emanuele Scifoni, Agata Skrzypek, Francesco Tommasino, Angelo Schiavi, Antoni Rucinski
Publikováno v:
Frontiers in Physics, Vol 8 (2021)
We present commissioning and validation of Fred, a graphical processing unit (GPU)–accelerated Monte Carlo code, for two proton beam therapy facilities of different beam line design: CCB (Krakow, IBA) and EMORY (Atlanta, Varian). We followed clinic
Externí odkaz:
https://doaj.org/article/6c8d9395749d4277ad4ec344a585896c
Autor:
Paulina Stasica, Jakub Baran, Carlos Granja, Nils Krah, Grzegorz Korcyl, Cristina Oancea, Monika Pawlik-Niedźwiecka, Szymon Niedźwiecki, Marzena Rydygier, Angelo Schiavi, Antoni Rucinski, Jan Gajewski
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
A precise characterization of therapeutic proton pencil beams is essential for the commissioning of any treatment planning system (TPS). The dose profile characterization includes measurement of the beam lateral dose profile in the beam core and far
Externí odkaz:
https://doaj.org/article/54cc5c33a0374eabb6ab8eaf2f4eca4e
Autor:
Sébastien A. Gauthier, Rocío Pérez-González, Ajay Sharma, Fang-Ke Huang, Melissa J. Alldred, Monika Pawlik, Gurjinder Kaur, Stephen D. Ginsberg, Thomas A. Neubert, Efrat Levy
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-13 (2017)
Abstract A dysfunctional endosomal pathway and abnormally enlarged early endosomes in neurons are an early characteristic of Down syndrome (DS) and Alzheimer’s disease (AD). We have hypothesized that endosomal material can be released by endosomal
Externí odkaz:
https://doaj.org/article/0877457119ae49328761f8470e3d617a
Autor:
Anna Wieczorek, Kamil Dulski, Szymon Niedźwiecki, Dominika Alfs, Piotr Białas, Catalina Curceanu, Eryk Czerwiński, Andrzej Danel, Aleksander Gajos, Bartosz Głowacz, Marek Gorgol, Beatrix Hiesmayr, Bożena Jasińska, Krzysztof Kacprzak, Daria Kamińska, Łukasz Kapłon, Andrzej Kochanowski, Grzegorz Korcyl, Paweł Kowalski, Tomasz Kozik, Wojciech Krzemień, Ewelina Kubicz, Mateusz Kucharek, Muhsin Mohammed, Monika Pawlik-Niedźwiecka, Marek Pałka, Lech Raczyński, Zbigniew Rudy, Oleksandr Rundel, Neha G Sharma, Michał Silarski, Tomasz Uchacz, Wojciech Wiślicki, Bożena Zgardzińska, Marcin Zieliński, Paweł Moskal
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0186728 (2017)
A novel plastic scintillator is developed for the application in the digital positron emission tomography (PET). The novelty of the concept lies in application of the 2-(4-styrylphenyl)benzoxazole as a wavelength shifter. The substance has not been u
Externí odkaz:
https://doaj.org/article/e963cf55995c44119c43e5ed5bf37d3b
Autor:
Belen Tizon, Susmita Sahoo, Haung Yu, Sebastien Gauthier, Asok R Kumar, Panaiyur Mohan, Matthew Figliola, Monika Pawlik, Anders Grubb, Yasuo Uchiyama, Urmi Bandyopadhyay, Ana Maria Cuervo, Ralph A Nixon, Efrat Levy
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9819 (2010)
Cystatin C (CysC) expression in the brain is elevated in human patients with epilepsy, in animal models of neurodegenerative conditions, and in response to injury, but whether up-regulated CysC expression is a manifestation of neurodegeneration or a
Externí odkaz:
https://doaj.org/article/b9db464fd7f9420fbe3b271004d02562