The immune response to melanoma is limited by thymic selection of self-antigens.

Autor: Ulrike Träger, Sophie Sierro, Gordana Djordjevic, Basma Bouzo, Shivani Khandwala, Antonella Meloni, Monika Mortensen, Anna Katharina Simon

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35005 (2012)

The expression of melanoma-associated antigens (MAA) being limited to normal melanocytes and melanomas, MAAs are ideal targets for immunotherapy and melanoma vaccines. As MAAs are derived from self, immune responses to these may be limited by thymic

Externí odkaz: https://doaj.org/article/ed1a3d63284a4a8086304ef2c13716d8

CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation

Autor: Monika Mortensen, Marja Jäättelä, José M.A. Moreira, Anna Rytter, Pekka Kohonen, Pietri Puustinen

Publikováno v: The Journal of Cell Biology

As part of a regulatory loop linking cell metabolism, growth, and proliferation, CIP2A promotes mTORC1-mediated cell growth and autophagy inhibition but is itself down-regulated by autophagy.
mTORC1 (mammalian target of rapamycin complex 1) inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd00f854bb320d431a54109ef085c66
http://europepmc.org/articles/PMC3941044

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

Autor: Gordana Djordjevic, Rebecca Tripp, Amanda J. Stranks, Elizabeth J. Soilleux, Monika Mortensen, Sten Eirik W. Jacobsen, Samantha J. L. Knight, Michael Lutteropp, Kamil R. Kranc, Elham Sadighi-Akha, Julie Glanville, Anna Katharina Simon

Publikováno v: Mortensen, M, Soilleux, E J, Djordjevic, G, Tripp, R, Lutteropp, M, Sadighi-Akha, E, Stranks, A J, Glanville, J, Knight, S, Jacobsen, S-E W, Kranc, K R & Simon, A K 2011, ' The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance ', Journal of Experimental Medicine, vol. 208, no. 3, pp. 455-67 . https://doi.org/10.1084/jem.20101145
The Journal of Experimental Medicine

Adult mouse LSK cells unable to undergo autophagy contain fewer HSCs, accumulate mitochondria, and fail to reconstitute lethally irradiated mice.
The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maint

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62f57e0ff5ef4960c0ba20c857aa751
https://doi.org/10.1084/jem.20101145

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

Autor: Alexander S, Watson, Thomas, Riffelmacher, Amanda, Stranks, Owen, Williams, Jasper, De Boer, Kelvin, Cain, Marion, MacFarlane, Joanna, McGouran, Benedikt, Kessler, Shivani, Khandwala, Onima, Chowdhury, Daniel, Puleston, Kanchan, Phadwal, Monika, Mortensen, David, Ferguson, Elizabeth, Soilleux, Petter, Woll, Sten Eirik W, Jacobsen, Anna Katharina, Simon

Publikováno v: Cell Death Discovery

Decreased autophagy contributes to malignancies; however, it is unclear how autophagy has an impact on tumor growth. Acute myeloid leukemia (AML) is an ideal model to address this as (i) patient samples are easily accessible, (ii) the hematopoietic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::103bee2fdf92e460659abd38b3d73026
https://pubmed.ncbi.nlm.nih.gov/26568842

Autophagy Controls Acquisition of Aging Features in Macrophages

Autor: Amanda J, Stranks, Anne Louise, Hansen, Isabel, Panse, Monika, Mortensen, David J P, Ferguson, Daniel J, Puleston, Kevin, Shenderov, Alexander Scarth, Watson, Marc, Veldhoen, Kanchan, Phadwal, Vincenzo, Cerundolo, Anna Katharina, Simon

Publikováno v: Journal of Innate Immunity

Macrophages provide a bridge linking innate and adaptive immunity. An increased frequency of macrophages and other myeloid cells paired with excessive cytokine production is commonly seen in the aging immune system, known as ‘inflamm-aging’. It i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aece3ceed0897eabd509a09673e8b0c0
https://pubmed.ncbi.nlm.nih.gov/25764971