Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Monika Martick"'
Publikováno v:
PLoS Biology, Vol 6, Iss 9, p e234 (2008)
We have obtained precatalytic (enzyme-substrate complex) and postcatalytic (enzyme-product complex) crystal structures of an active full-length hammerhead RNA that cleaves in the crystal. Using the natural satellite tobacco ringspot virus hammerhead
Externí odkaz:
https://doaj.org/article/2c7eee625ab74664839655b8acde31a2
Publikováno v:
Journal of molecular biology, vol 427, iss 12
Guanine-rich sequences can, under appropriate conditions, adopt a distinctive, four-stranded, helical fold known as a G-quadruplex. Interest in quadruplex folds has grown in recent years as evidence of their biological relevance has accumulated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6c5d896a22d1142b9f8828bec1d5de
https://doi.org/10.1016/j.jmb.2015.03.022
https://doi.org/10.1016/j.jmb.2015.03.022
The Crystal Structure of the Escherichia coli RNase E Apoprotein and a Mechanism for RNA Degradation
Autor:
Monika Martick, Ben F. Luisi, Daniel J. Koslover, Maria J. Marcaida, William G. Scott, Elspeth F. Garman, Anastasia J. Callaghan
Publikováno v:
Structure (London, England : 1993), vol 16, iss 8
Koslover, DJ; Callaghan, AJ; Marcaida, MJ; Garman, EF; Martick, M; Scott, WG; et al.(2008). The Crystal Structure of the Escherichia coli RNase E Apoprotein and a Mechanism for RNA Degradation. Structure, 16(8), 1238-1244. doi: 10.1016/j.str.2008.04.017. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/8c46v3sn
Structure(London, England:1993)
Koslover, DJ; Callaghan, AJ; Marcaida, MJ; Garman, EF; Martick, M; Scott, WG; et al.(2008). The Crystal Structure of the Escherichia coli RNase E Apoprotein and a Mechanism for RNA Degradation. Structure, 16(8), 1238-1244. doi: 10.1016/j.str.2008.04.017. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/8c46v3sn
Structure(London, England:1993)
RNase E is an essential bacterial endoribonuclease involved in the turnover of messenger RNA and the maturation of structured RNA precursors in Escherichia coli. Here, we present the crystal structure of the E. coli RNase E catalytic domain in the ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c287c7441d521ec1159bea14afee3b7b
https://doi.org/10.1016/j.str.2008.04.017
https://doi.org/10.1016/j.str.2008.04.017
Publikováno v:
Nature, vol 454, iss 7206
Martick, M; Horan, LH; Noller, HF; & Scott, WG. (2008). A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA. Nature, 454(7206), 899-902. doi: 10.1038/nature07117. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/0s61d1kb
Martick, M; Horan, LH; Noller, HF; & Scott, WG. (2008). A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA. Nature, 454(7206), 899-902. doi: 10.1038/nature07117. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/0s61d1kb
Structured RNAs embedded in the untranslated regions (UTRs) of messenger RNAs can regulate gene expression. In bacteria, control of a metabolite gene is mediated by the self-cleaving activity of a ribozyme embedded in its 5′ UTR. This discovery has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15940cf368ac0ddf539f6c4a106efd6
https://doi.org/10.1038/nature07117
https://doi.org/10.1038/nature07117
Autor:
Monika Martick, Christine Yuncker, Leslie E. Fox, Janet Wojciechowski, Elizabeth Aquilla, George M. Happ
Publikováno v:
Veterinary Immunology and Immunopathology. 69:93-100
Class-II histocompatibility genes are associated with predisposition to autoimmune diseases in many mammal species. We have developed a technique using reverse transcriptase and nested-PCR for amplification from blood samples of expressed sequences e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1dd7b1c7dc51dbfe2e854ff8818acd
https://doi.org/10.1016/s0165-2427(99)00045-8
https://doi.org/10.1016/s0165-2427(99)00045-8
Publikováno v:
Journal of Chemical Theory and Computation. 3:325-327
Results of a series of 12 ns molecular dynamics (MD) simulations of the reactant state (with and without a Mg(2+) ion), early and late transition state mimics are presented based on a recently reported crystal structure of a full-length hammerhead RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2f4b7fdc8eea3bb0311f9204692b90e
https://doi.org/10.1021/ct6003142
https://doi.org/10.1021/ct6003142
Publikováno v:
Journal of molecular biology, vol 425, iss 20
Anderson, M; Schultz, EP; Martick, M; & Scott, WG. (2013). Active-site monovalent cations revealed in a 1.55-Å-resolution hammerhead ribozyme structure. Journal of Molecular Biology, 425(20), 3790-3798. doi: 10.1016/j.jmb.2013.05.017. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/51c58166
Anderson, M; Schultz, EP; Martick, M; & Scott, WG. (2013). Active-site monovalent cations revealed in a 1.55-Å-resolution hammerhead ribozyme structure. Journal of Molecular Biology, 425(20), 3790-3798. doi: 10.1016/j.jmb.2013.05.017. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/51c58166
We have obtained a 1.55-Å crystal structure of a hammerhead ribozyme derived from Schistosoma mansoni under conditions that permit detailed observations of Na+ion binding in the ribozyme's active site. At least two such Na+ions are observed. The fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df60863e2d9821f9f67d19ea008ba12
https://escholarship.org/uc/item/51c58166
https://escholarship.org/uc/item/51c58166
The hammerhead ribozyme has long been considered a prototype for understanding RNA catalysis, but discrepancies between the earlier crystal structures of a minimal hammerhead self-cleaving motif and various biochemical investigations frustrated attem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ae64940b7359ecacd82805715f1c44
https://doi.org/10.1016/b978-0-12-381286-5.00001-9
https://doi.org/10.1016/b978-0-12-381286-5.00001-9
Autor:
Carlos P. Sosa, William G. Scott, George M. Giambaşu, Darrin M. York, Monika Martick, Tai-Sung Lee
Publikováno v:
Lee, TS; Giambaşu, GM; Sosa, CP; Martick, M; Scott, WG; & York, DM. (2009). Threshold Occupancy and Specific Cation Binding Modes in the Hammerhead Ribozyme Active Site are Required for Active Conformation. Journal of Molecular Biology, 388(1), 195-206. doi: 10.1016/j.jmb.2009.02.054. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/75k1f2gq
Journal of molecular biology, vol 388, iss 1
Journal of molecular biology, vol 388, iss 1
The relationship between formation of active in-line attack conformations and monovalent (Na+) and divalent (Mg2+) metal ion binding in the hammerhead ribozyme has been explored with molecular dynamics simulations. To stabilize repulsions between neg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160db5c5b161c84d47bd3c30533c7844
http://www.escholarship.org/uc/item/75k1f2gq
http://www.escholarship.org/uc/item/75k1f2gq
Publikováno v:
Journal of chemical theory and computation. 3(2)
Results of a series of 12 ns molecular dynamics (MD) simulations of the reactant state (with and without a Mg(2+) ion), early and late transition state mimics are presented based on a recently reported crystal structure of a full-length hammerhead RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7400e7b7361b5f30a99ce9d3584e267b
https://pubmed.ncbi.nlm.nih.gov/19079784
https://pubmed.ncbi.nlm.nih.gov/19079784