Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Monika Macakova"'
Autor:
Bozena Bohuslavova, Jana Klouckova, Jan Motlik, Michael E. Talkowski, Monika Baxa, James F. Gusella, Ivona Valekova, David Howland, Marian DiFiglia, Martin Haluzik, Jiri Klempir, Klara Vochyanova, Antonin Pavlok, Jana Juhasova, Ian Blumenthal, Hana Hansikova, Miroslava Sedláčková, Jiri Klima, Stefan Juhas, Zdenka Ellederova, Daniela Vidinska, Monika Macakova, Jana Spacilova, Irena Liskova, Petra Vochozkova, Ryan L. Collins
Publikováno v:
Neurodegenerative Diseases. 16:245-259
Background: Huntington's disease is induced by CAG expansion in a single gene coding the huntingtin protein. The mutated huntingtin (mtHtt) primarily causes degeneration of neurons in the brain, but it also affects peripheral tissues, including teste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6ca9a1e8e3346377f6ade06863b0b4
https://doi.org/10.1159/000443665
https://doi.org/10.1159/000443665
Autor:
Bozena Bohuslavova, Monika Macakova, Jan Motlik, Šárka Kučerová, Jiri Klempir, Zdenka Ellederova, Monika Baxa
Publikováno v:
Models for HD.
Hunting for the cure for Huntington´s disease (HD) requires extended pre-clinical studies to screen the safety, tolerability and efficacy of the potential therapeutic treatments. Therefore, the large animal models were developed for translational re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a388d36c48f3d5b1f16c65b1094f4ce
https://doi.org/10.1136/jnnp-2018-ehdn.60
https://doi.org/10.1136/jnnp-2018-ehdn.60
Autor:
Petra Rausova, Petra Vochozkova, Daniela Vidinska, Eva Hrnciarova, Bozena Bohuslavova, Monika Macakova, Ivona Valekova, Stefan Juhas, Taras Ardan, Petr Solc, Jan Motlik, Zdenka Ellederova
Publikováno v:
Huntington's Disease-Molecular Pathogenesis and Current Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6bfb46decbf8caefd529d6e0238248
https://doi.org/10.5772/66353
https://doi.org/10.5772/66353
Autor:
David Howland, Monika Macakova, Antonin Pavlok, Jiri Zeman, Daniela Vidinska, Hana Hansikova, Marie Rodinova, Jiri Klima, Hana Stufkova, Jana Krizova, Jan Motlik, Bozena Bohuslavova, Zdenka Ellederova
Publikováno v:
Neuro-degenerative diseases. 17(4-5)
Background: Huntington disease (HD) is a fatal neurodegenerative disorder involving reduced muscle coordination, mental and behavioral changes, and testicular degeneration. In order to further clarify the decreased fertility and penetration ability o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a661461fbf0d586f99d1841893b7f51b
https://pubmed.ncbi.nlm.nih.gov/28633139
https://pubmed.ncbi.nlm.nih.gov/28633139
Autor:
Petr Vodicka, Silvia Marsala, Jiri Klima, Radek Vrtel, Monika Macakova, Elena Cattaneo, Jan Schier, Tetsuya Nejime, Stefan Juhas, Jana Juhasova, Marian Hruska-Plochan, Monika Baxa, Atsushi Miyanohara, Emily M. Sontag, Hana Hansikova, Andreas Weiss, Jan Motlik, Svatava Kubickova, Petra Musilova, Martin Marsala, Antonin Pavlok, Leslie M. Thompson, Marian DiFiglia, David Howland
Publikováno v:
Journal of Huntington's disease. 2(1)
BACKGROUND Some promising treatments for Huntington's disease (HD) may require pre-clinical testing in large animals. Minipig is a suitable species because of its large gyrencephalic brain and long lifespan. OBJECTIVE To generate HD transgenic (TgHD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf123c6e09137797fdebcc449679f119
https://pubmed.ncbi.nlm.nih.gov/25063429
https://pubmed.ncbi.nlm.nih.gov/25063429
Autor:
Tereza Tykalová, Jan Rusz, Jiří Klempíř, Jan Motlik, Monika Baxa, Monika Macakova, Roman Cmejla, Jan Hlavnička
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A32.2-A32
Background Voice quality of patients with Huntington’s disease is commonly perceived as harsh, hoarse, or breathy. Digital signal analysis allows to quantify the degree of hoarseness objectively by harmonic-to-noise ratio. Such a simple automated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2baad7987341b95cc47957c136e3e13a
https://doi.org/10.1136/jnnp-2016-314597.96
https://doi.org/10.1136/jnnp-2016-314597.96
Autor:
Monika Macakova, Zdenka Ellederova, Jiri Klempir, Monika Baxa, Radim Krupicka, Jan Kauler, Jan Motlik, Šárka Kučerová, Romana Lavickova, Bozena Bohuslavova
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A30.2-A30
Background Huntington’s disease (HD) is characterised by involuntary chorea like movements, poor balance, slurred speech, difficulty swallowing, personality change and difficulty thinking manifesting in the middle age of the patients. Changes in be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82376350b73071aa425bc6aeb56e37ab
https://doi.org/10.1136/jnnp-2016-314597.91
https://doi.org/10.1136/jnnp-2016-314597.91
Autor:
Monika Macakova, Jan Motlik, Antonin Pavlok, Jiri Zeman, Jana Krizova, Hana Stufkova, Marie Rodinova, Hana Hansikova, Zdenka Ellederova, Bozena Bohuslavova
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A33.1-A33
Background Large-animal minipig transgenic model of Huntington’s disease (HD), carrying N-terminal part of human mutated huntingtin, was developed in Libechov and is expected to resemble to clinical picture of HD patients. Phenotyping of this model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a7ebc1fa3c7f9ed5fca3bf0f53b8f6e
https://doi.org/10.1136/jnnp-2016-314597.98
https://doi.org/10.1136/jnnp-2016-314597.98
Autor:
Zdenka Ellederova, I. Liskova, Jiri Klempir, Jan Roth, J. Spacilova, Bozena Bohuslavova, Marie Rodinova, Jana Sladkova, Jiří Zeman, Monika Macakova, Jan Motlik, Hana Kratochvílová, Jana Juhasova, M Marková, Hana Hansikova
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A20-A21
The most pathological effects of Huntington’s disease (HD) are focused on the central nervous system but numerous reports had described abnormalities in peripheral tissues. Mutant huntingtin (Htt) has been implicated in disruptions of multiple cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7de188cadaa7685ecb3882e84f882ded
https://doi.org/10.1136/jnnp-2014-309032.61
https://doi.org/10.1136/jnnp-2014-309032.61
Autor:
Jan Motlik, Monika Macakova, Jana Juhasova, Jiří Zeman, Zuzana Hájková, S Juha, Monika Baxa, J Sádková, P Antonín, Hana Hansikova
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 83:A16.2-A16
Testicular degeneration of Huntington9s disease involves the reduction of germ cells and wall thickening of seminiferous tubule. Since changes in ejaculates of patients and mammalians models has not yet been tested, the aim of our study was to analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d459145c0fe26e667a143385fa8108c
https://doi.org/10.1136/jnnp-2012-303524.51
https://doi.org/10.1136/jnnp-2012-303524.51