Design, synthesis and antiproliferative activity against human cancer cell lines of novel benzo-, benzofuro-, azolo- and thieno-1,3-thiazinone resorcinol hybrids

Autor: Joanna Matysiak, Monika M. Karpińska, Alicja Skrzypek, Joanna Wietrzyk, Dagmara Kłopotowska, Andrzej Niewiadomy, Beata Paw, Małgorzata Juszczak, Wojciech Rzeski

Publikováno v: Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 2655-2667 (2019)

In this paper we report the design and synthesis of novel derivatives of the 4H-3,1-benzothiazinone type and heterocyclic analogues, i.e. benzofuro-, azolo- and thieno-1,3-thiazin-4-ones possessing 2,4-dihydroxyphenyl substituent. The compounds were

Externí odkaz: https://doaj.org/article/edb6e54e88d94d6fb32c4a8b5a16ca2b

Navigating the limitations, assumptions and conceptual pitfalls of Nd isotope research on peatlands: Reply to the comments of Le Roux et al. (2023) on 'Neodymium isotopes in peat reveal past local environmental disturbances' by Marcisz et al. (2023).

Autor: Marcisz K; Climate Change Ecology Research Unit, Adam Mickiewicz University, Poznań, Poland. Electronic address: marcisz@amu.edu.pl., Belka Z; Isotope Research Unit, Adam Mickiewicz University, Poznań, Poland., Dopieralska J; Isotope Laboratory, Poznań Science and Technology Park, Adam Mickiewicz University Foundation, Poznań, Poland., Jakubowicz M; Isotope Research Unit, Adam Mickiewicz University, Poznań, Poland., Karpińska-Kołaczek M; Climate Change Ecology Research Unit, Adam Mickiewicz University, Poznań, Poland., Kołaczek P; Climate Change Ecology Research Unit, Adam Mickiewicz University, Poznań, Poland., Mauquoy D; School of Geosciences, University of Aberdeen, Aberdeen, UK., Słowiński M; Past Landscape Dynamics Laboratory, Institute of Geography and Spatial Organization, Polish Academy of Sciences, Warsaw, Poland., Zieliński M; Isotope Research Unit, Adam Mickiewicz University, Poznań, Poland., Lamentowicz M; Climate Change Ecology Research Unit, Adam Mickiewicz University, Poznań, Poland.

Publikováno v: The Science of the total environment [Sci Total Environ] 2023 Nov 10; Vol. 898, pp. 165398. Date of Electronic Publication: 2023 Jul 16.

Cholinesterases Inhibition, Anticancer and Antioxidant Activity of Novel Benzoxazole and Naphthoxazole Analogs.

Autor: Skrzypek A; Department of Chemistry, University of Life Sciences, Akademicka 15, 20-950 Lublin, Poland., Karpińska M; Institute of Industrial Organic Chemistry, Łukasiewicz Research Network, Annopol 6, 03-236 Warsaw, Poland., Juszczak M; Department of Medical Biology, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland., Grabarska A; Department of Biochemistry and Molecular Biology, Medical University, Chodźki 1, 20-090 Lublin, Poland., Wietrzyk J; Department of Experimental Oncology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland., Krajewska-Kułak E; Department of Integrated Medical Care, Medical University, M. Skłodowska-Curie 7A, 15-094 Białystok, Poland., Studziński M; Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry, Maria Curie-Skłodowska University, Pl. M. C. Skłodowkiej 3, 20-031 Lublin, Poland., Paszko T; Department of Chemistry, University of Life Sciences, Akademicka 15, 20-950 Lublin, Poland., Matysiak J; Department of Chemistry, University of Life Sciences, Akademicka 15, 20-950 Lublin, Poland.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Dec 03; Vol. 27 (23). Date of Electronic Publication: 2022 Dec 03.

Pancreas-Its Functions, Disorders, and Physiological Impact on the Mammals' Organism.

Autor: Karpińska M; The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Warsaw, Poland., Czauderna M; The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Warsaw, Poland.

Publikováno v: Frontiers in physiology [Front Physiol] 2022 Mar 30; Vol. 13, pp. 807632. Date of Electronic Publication: 2022 Mar 30 (Print Publication: 2022).

Biological evaluation and molecular docking of novel 1,3,4-thiadiazole-resorcinol conjugates as multifunctional cholinesterases inhibitors.

Autor: Skrzypek A; Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland., Matysiak J; Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland. Electronic address: joanna.matysiak@up.lublin.pl., Karpińska M; Łukasiewicz Research Network - Institute of Industrial Organic Chemistry, Annopol 6, 03-236 Warsaw, Poland., Czarnecka K; Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland., Kręcisz P; Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland., Stary D; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland., Kukułowicz J; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland., Paw B; Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland., Bajda M; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland., Szymański P; Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland., Niewiadomy A; Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Feb; Vol. 107, pp. 104617. Date of Electronic Publication: 2021 Jan 05.