Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice.

Autor: Kathleen L DeCicco-Skinner, Sabrina J Nolan, Monika M Deshpande, Erika L Trovato, Taylor A Dempsey, Jonathan S Wiest

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56212 (2013)

Squamous cell carcinoma is the second most common form of skin cancer with the incidence expected to double over the next 20 years. Inflammation is believed to be a critical component in skin cancer progression. Therefore, understanding genes involve

Externí odkaz: https://doaj.org/article/ec4f6cd7628c48cd941f67bc58c90418

Characterization of nitric oxide signaling pathways in the mouse retina

Autor: Tom Giove, Jan Blom, William D. Eldred, Monika M. Deshpande

Publikováno v: The Journal of comparative neurology. 520(18)

Nitric oxide (NO) is a gaseous neuromodulator with physiological functions in every retinal cell type. NO is synthesized by several nitric oxide synthases (NOS) and often functions through its second messenger, cyclic guanosine monophosphate (cGMP),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3d95ca8bc3ca67f08348ed3b21619c
https://pubmed.ncbi.nlm.nih.gov/22592770

Food and Drug Administration Public Workshop Summary-Development Considerations of Antifungal Drugs to Address Unmet Medical Need.

Autor: Yasinskaya Y; Division of Anti-Infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA., Bala S; Division of Anti-Infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA., Waack U; Division of Anti-Infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA., Dixon C; Division of Biometrics IV, Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration ; Silver Spring, Maryland, USA., Higgins K; Division of Biometrics IV, Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration ; Silver Spring, Maryland, USA., Moore JN; Division of Infectious Disease Pharmacology, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration ; Silver Spring, Maryland, USA., Jjingo CJ; Division of Anti-Infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA., O'Shaughnessy E; Division of Anti-Infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA., Colangelo P; Division of Infectious Disease Pharmacology, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration ; Silver Spring, Maryland, USA., Botgros R; Health Threats and Vaccines Strategy, European Medicines Agency, Amsterdam, the Netherlands., Nambiar S; Division of Anti-Infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA., Angulo D; Scynexis, Jersey City, New Jersey, USA., Dane A; DaneStat Consulting, Macclesfield, United Kingdom., Chiller T; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Hodges MR; RNA Medicines, San Diego, California, USA., Sandison T; Cidara Therapeutics, San Diego, California, USA., Hope W; Centre for Excellence in Infectious Diseases Research, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Walsh TJ; Transplantation-Oncology Infectious Diseases Program, Weill Cornell Medicine, New York, New York, USA., Pappas P; Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA., Katragkou A; Transplantation-Oncology Infectious Disease Program, Weill Cornell Medicine, New York, New York, USA., Kovanda L; Astellas Pharma Global Development, Northbrook, Illinois, USA., Rex JH; F2G, Manchester, United Kingdom., Marr KA; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Ostrosky-Zeichner L; Director of the Laboratory of Mycology Research, McGovern Medical School, Houston, Texas, USA., Sekine S; Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Deshpande M; DRT Strategies, Arlington, Virginia, USA., Shukla SJ; Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA., Farley J; Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Aug 14; Vol. 77 (3), pp. 380-387.

HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease.

Autor: Guo C; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Deshpande M; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Niu Y; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Kachwala I; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Flores-Bellver M; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, CO 80045, USA., Megarity H; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Nuse T; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Babapoor-Farrokhran S; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Ramada M; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Sanchez J; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Inamdar N; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Johnson TV; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Canto-Soler MV; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, CO 80045, USA., Montaner S; Department of Oncology and Diagnostic Sciences, School of Dentistry, Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA., Sodhi A; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: asodhi1@jhmi.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Jan 31; Vol. 42 (1), pp. 111976. Date of Electronic Publication: 2023 Jan 10.

HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.

Autor: Zhang J; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China., Qin Y; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China., Martinez M; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Flores-Bellver M; CellSight, Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, Colorado, USA., Rodrigues M; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Dinabandhu A; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology and Diagnostic Sciences, School of Dentistry, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, USA., Cao X; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Deshpande M; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Qin Y; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Ophthalmology, Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang, Liaoning, China., Aparicio-Domingo S; CellSight, Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, Colorado, USA., Rui Y; Department of Biomedical Engineering, Institute for NanoBioTechnology, and Translational Tissue Engineering Center, and., Tzeng SY; Department of Biomedical Engineering, Institute for NanoBioTechnology, and Translational Tissue Engineering Center, and., Salman S; Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, Biological Chemistry, and Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Yuan J; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China., Scott AW; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Green JJ; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Institute for NanoBioTechnology, and Translational Tissue Engineering Center, and., Canto-Soler MV; CellSight, Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, Colorado, USA., Semenza GL; Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, Biological Chemistry, and Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Montaner S; Department of Oncology and Diagnostic Sciences, School of Dentistry, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, USA., Sodhi A; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Jun 15; Vol. 131 (12).