Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Monika M. Clowes"'
Publikováno v:
Journal of Clinical Investigation. 102:1413-1420
Although matrix metalloproteinases (MMPs) are expressed in abundance in arterial aneurysms, their contribution to arterial wall degeneration, dilation, and rupture has not been determined. We investigated MMP function in a rat model of aneurysm assoc
Publikováno v:
Circulation Research. 82:862-870
Abstract —Endothelial cells in normal blood vessels might prevent the unscheduled proliferation of smooth muscle cells (SMCs) by the expression of cell migration and growth inhibitors. NO, a potent vasodilator, generated by endothelium-specific con
Autor:
Reza Forough, David Hasenstab, Eric Allaire, Monika M. Clowes, Holly Lea, Barry Starcher, Alexander W. Clowes
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 18:803-807
Abstract —We have recently demonstrated that the blockade of matrix metalloproteinases by local overexpression of the intrinsic inhibitor tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) reduces intimal hyperplasia. We now report a major cha
Publikováno v:
Journal of Surgical Research. 70:178-186
Arterial smooth muscle cell (SMC) proliferation is an important factor in the development of atherosclerotic plaques and restenotic lesions following arterial reconstruction. Basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF
Publikováno v:
Journal of Biological Chemistry. 271:25928-25935
Heparin is a complex glycosaminoglycan that inhibits vascular smooth muscle cell (SMC) growth in vitro and in vivo. To define the mechanism by which heparin exerts its antiproliferative effects, we asked whether heparin interferes with the activity o
Autor:
Holly Lea, Monika M. Clowes, David Hasenstab, Reza Forough, Seppo T. Nikkari, Noriyuki Koyama, Alexander W. Clowes
Publikováno v:
Circulation Research. 79:812-820
Arterial smooth muscle cells (SMCs) are in a quiescent growth state under normal physiological conditions, but they can be stimulated to proliferate and migrate from one tissue compartment to another if the vessel is injured. This response might requ
Publikováno v:
Journal of Vascular Research. 30:161-168
The effect of heparin on the amount of membrane-associated heparan sulfate proteoglycan (HSPG) was examined biochemically in balloon-injured rat carotid arteries. Heparin (Choay 1772) was administered at the rate of 1 mg/kg/h.i.v. by an osmotic infus
Autor:
Mats Hedberg, Gunilla Bengtsson-Olivecrona, A. Leizorovicz, Lars N. Jorgensen, U. Spannagel, Per Østergaard, Thomas Mätzsch, Tina Au, Ulla Hedner, Graham F. Pineo, Gary E. Raskob, Karl-Gösta Ljungström, Ole Nordfang, Jan Holst, Bengt Lindblad, Jan Frisell, P. Kujath, Qingyu Wu, Robert D. Rosenberg, Per Anders Flordal, P. Østergaard, Ulf Nyman, M.C. Haugh, Peer Wille-Jørgensen, Carlos A. Labarrere, Ulrich Abildgaard, John P. Sheehan, Evan Sadler, Gert Nielsen, Richard D. Kenagy, Page Faulk, Tetsuhito Kojima, Lars C. Borris, Iver Lausen, H. Kristensen, Russell D. Hull, Magnus Hultin, Gwendolyn J. Stewart, Anthony J. Comerota, Joan Dawes, Bertil Friberg, John A. Mclntyre, Alexander W. Clowes, Donald S. Torry, David Bergqvist, Thomas Olivecrona, Trevor W. Barrowcliffe, L.C. Petersen, Olivier Chevreuil, Jens L. Petersen, Jane Wilson, Andrew N. Nicolaides, Monika M. Clowes, Guoqing Liu, Ana Padilla, M.M. Samama, O. Nordfang, Evi Kalodiki, Mira L. Katz, Colin G. Taylor, Dawn R. Wagenknecht, Steven R. Lentz, S. Valentin, V.V. Kakkar, Klas Norrby, Nicholas W. Shworak, Göran Nylander, L. Bara, W. Habscheid, Elaine Gray, Staffan Törngren, Michael R. Lassen, Barry Halliwell, Homayoun Hashemi, Manuel Tsiang
Publikováno v:
Pathophysiology of Haemostasis and Thrombosis. 23:I-IV
Publikováno v:
Pathophysiology of Haemostasis and Thrombosis. 23:177-182
Heparin, an inhibitor of vascular smooth muscle cell proliferation and migration, affects a number of other cell functions. These effects include inhibition of growth factor binding, deposition of matrix proteins and gene expression. Various mechanis
Autor:
Alexander W. Clowes, Daniel F. Bowen-Pope, Michael A. Reidy, Andreas Faulmuller, Gottfried Muller, Jürgen Fingerle, Monika M. Clowes
Publikováno v:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 12:1488-1495
Intimal thickening in response to vascular injury is inhibited in animals previously subjected to hypophysectomy. We have investigated the nature and cell kinetics of this effect in a balloon catheter model of injury to the rat carotid artery. The ab