Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model

Autor: Santosh Dhakal, Camilo A. Ruiz-Bedoya, Ruifeng Zhou, Patrick S. Creisher, Jason S. Villano, Kirsten Littlefield, Jennie Ruelas Castillo, Paula Marinho, Anne E. Jedlicka, Alvaro A. Ordonez, Melissa Bahr, Natalia Majewska, Michael J. Betenbaugh, Kelly Flavahan, Alice R. L. Mueller, Monika M. Looney, Darla Quijada, Filipa Mota, Sarah E. Beck, Jacqueline Brockhurst, Alicia M. Braxton, Natalie Castell, Mitchel Stover, Franco R. D’Alessio, Kelly A. Metcalf Pate, Petros C. Karakousis, Joseph L. Mankowski, Andrew Pekosz, Sanjay K. Jain, Sabra L. Klein

Publikováno v: mBio, Vol 12, Iss 4 (2021)

ABSTRACT In the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more severe outcomes are reported in males than in females, including hospitalizations and deaths. Animal models

Externí odkaz: https://doaj.org/article/c26a3303ffd040088f12495ee7b31392

Mycobacterium tuberculosis Infection Drives Mitochondria-Biased Dysregulation of Host Transfer RNA–Derived Fragments

Autor: Marc K. Halushka, Petros C. Karakousis, Monika M Looney, Yin Lu

Publikováno v: J Infect Dis

Background Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, causes 10 million infections and 1.5 million deaths per year worldwide. The success of Mtb as a human pathogen is directly related to its ability to suppress host re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc49608907b5646abe8f49c0e29228d0
https://doi.org/10.1093/infdis/jiaa596

Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model

Autor: Franco R. D'Alessio, Alicia M Braxton, Paula Marinho, Filipa Mota, Sabra L. Klein, Sanjay K. Jain, Jacqueline Brockhurst, Alvaro A. Ordonez, Natalia I. Majewska, Kelly Flavahan, Alice R L Mueller, Ruifeng Zhou, Jennie Ruelas Castillo, Melissa Bahr, Kelly A. Metcalf Pate, Joseph L. Mankowski, Mitchel Stover, Andrew Pekosz, Anne E. Jedlicka, Monika M Looney, Natalie Castell, Patrick S. Creisher, Kirsten Littlefield, Camilo A. Ruiz-Bedoya, Darla Quijada, Sarah E. Beck, Michael J. Betenbaugh, Jason S Villano, Petros C. Karakousis, Santosh Dhakal

Publikováno v: mBio
mBio, Vol 12, Iss 4 (2021)
bioRxiv

In the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more severe outcomes are reported in males compared with females, including hospitalizations and deaths. Animal mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b4633b3a9deb0f3245f3c4bc48af88
https://doi.org/10.1128/mbio.00974-21

Key Macrophage Responses to Infection With Mycobacterium tuberculosis Are Co-Regulated by microRNAs and DNA Methylation

Autor: Petros C. Karakousis, Monika M Looney, Rachel Lorenc, Marc K. Halushka

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

Tuberculosis (TB) is the leading cause of death from infection with a single bacterial pathogen. Host macrophages are the primary cell type infected with Mycobacterium tuberculosis (Mtb), the organism that causes TB. Macrophage response pathways are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8eb1b98531809a03ce57e071f3c6e8d
http://europepmc.org/articles/PMC8204050

Bystander monocytic cells drive infection-independent NLRP3 inflammasome response to SARS-CoV-2.

Autor: Hsieh LL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA., Looney M; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Figueroa A; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Massaccesi G; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Stavrakis G; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA., Anaya EU; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA., D'Alessio FR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Ordonez AA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Pekosz AS; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA., DeFilippis VR; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA., Karakousis PC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Karaba AH; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Cox AL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Publikováno v: MBio [mBio] 2024 Oct 16; Vol. 15 (10), pp. e0081024. Date of Electronic Publication: 2024 Sep 06.