Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Monika Lodyga"'
Autor:
Christina Doherty, Monika Lodyga, Judy Correa, Caterina Di Ciano-Oliveira, Pamela J. Plant, James R. Bain, Jane Batt
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1847 (2024)
Peripheral nerve injury denervates muscle, resulting in muscle paralysis and atrophy. This is reversible if timely muscle reinnervation occurs. With delayed reinnervation, the muscle’s reparative ability declines, and muscle-resident fibro-adipogen
Externí odkaz:
https://doaj.org/article/dcec74a848934eaf9f0276fe29eb1ab3
Autor:
Ola Redha, Morteza Mazinanian, Sabrina Nguyen, Dong Ok Son, Monika Lodyga, Boris Hinz, Marianne Odlyha, Ailbhe McDonald, Laurent Bozec
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract This study aimed to assess the viability of dental cells following time-dependent carbamide peroxide teeth-whitening treatments using an in-vitro dentin perfusion assay model. 30 teeth were exposed to 5% or 16% CP gel (4 h daily) for 2-weeks
Externí odkaz:
https://doaj.org/article/3d9876734b234b128f12ac9ecadc35ed
Autor:
Jennifer Ly Tsang, Song Hui Jia, Jean Parodo, Pamela Plant, Monika Lodyga, Emmanuel Charbonney, Katalin Szaszi, Andras Kapus, John C Marshall
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153946 (2016)
Src family tyrosine kinases (SFKs) phosphorylate caspase-8A at tyrosine (Y) 397 resulting in suppression of apoptosis. In addition, the phosphorylation of caspase-8A at other sites including Y465 has been implicated in the regulation of caspase-8 act
Externí odkaz:
https://doaj.org/article/e09d8989f6c54ece844e48e37a995e2f
Autor:
John Blaikley, Andrew S. I. Loudon, Peter Meijer, Andrew J. Fisher, Karen Piper-Hanley, Neil C. Henderson, Alicja Nazgiewicz, Rajamayier V. Venkateswaran, Gareth B. Kitchen, Martin K. Rutter, James Bagnall, Rachel C. Chambers, Lee A. Borthwick, Boris Hinz, Nicola Begley, Peter S. Cunningham, Rajesh Shah, Julie E. Gibbs, David W. Ray, Simon G. Anderson, Monika Lodyga, Paul F. Mercer, David A. Bechtold, Hannah J. Durrington
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Cunningham, P, Meijer, P, Nazgiewicz, A, Anderson, S, Borthwick, L A, Bagnall, J, Kitchen, G, Lodyga, M, Begley, N, Venkateswaran, R, Shah, R, Mercer, P F, Durrington, H, Henderson, N, Piper Hanley, K, Fisher, A, Chambers, R C, Bechtold, D, Gibbs, J, Loudon, A, Rutter, M K, Hinz, B, Ray, D & Blaikley, J 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Cunningham, P S, Meijer, P, Nazgiewicz, A, Anderson, S G, Borthwick, L A, Bagnall, J, Kitchen, G B, Lodyga, M, Begley, N, Venkateswaran, R V, Shah, R, Mercer, P F, Durrington, H J, Henderson, N C, Piper-hanley, K, Fisher, A J, Chambers, R C, Bechtold, D A, Gibbs, J E, Loudon, A S, Rutter, M K, Hinz, B, Ray, D W & Blaikley, J F 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Cunningham, P, Meijer, P, Nazgiewicz, A, Anderson, S, Borthwick, L A, Bagnall, J, Kitchen, G, Lodyga, M, Begley, N, Venkateswaran, R, Shah, R, Mercer, P F, Durrington, H, Henderson, N, Piper Hanley, K, Fisher, A, Chambers, R C, Bechtold, D, Gibbs, J, Loudon, A, Rutter, M K, Hinz, B, Ray, D & Blaikley, J 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Cunningham, P S, Meijer, P, Nazgiewicz, A, Anderson, S G, Borthwick, L A, Bagnall, J, Kitchen, G B, Lodyga, M, Begley, N, Venkateswaran, R V, Shah, R, Mercer, P F, Durrington, H J, Henderson, N C, Piper-hanley, K, Fisher, A J, Chambers, R C, Bechtold, D A, Gibbs, J E, Loudon, A S, Rutter, M K, Hinz, B, Ray, D W & Blaikley, J F 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Significance The circadian clock plays an essential role in energy metabolism and inflammation. In contrast, the importance of the clock in the pathogenesis of fibrosis remains poorly explored. This study describes a striking alteration in circadian
Autor:
Marianne Odlyha, Boris Hinz, Laurent Bozec, Ailbhe McDonald, Morteza Mazinanian, Ola Redha, Sabrina Nguyen, Dong Ok Son, Monika Lodyga
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
This study aimed to assess the viability of dental cells following time-dependent carbamide peroxide teeth-whitening treatments using an in-vitro dentin perfusion assay model. 30 teeth were exposed to 5% or 16% CP gel (4 h daily) for 2-weeks. The ena
Autor:
Nina Noskovičová, Dong Ok Son, Boris Hinz, Monika Lodyga, Ronen Schuster, Henna Karvonen, Pardis Pakshir, Amanda Goodwin
Publikováno v:
Journal of cell science. 133(13)
In 1971, Gabbiani and co-workers discovered and characterized the “modification of fibroblasts into cells which are capable of an active spasm” (contraction) in rat wound granulation tissue and, accordingly, named these cells ‘myofibroblasts’
Autor:
Boris Hinz, Monika Lodyga
Publikováno v:
Seminars in celldevelopmental biology. 101
'Jack of all trades, master of everything' is a fair label for transforming growth factor β1 (TGF-β) - a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is critical for the development and maturation of immune cells,
Autor:
Mohit Kapoor, Kjetil Ask, Brian Wu, Stellar Boo, Pardis Pakshir, Boris Hinz, Henna Karvonen, Michael Glogauer, Riitta Kaarteenaho, Elizabeth Cambridge, Monika Lodyga, Melanie Kiebalo
Publikováno v:
Science Signaling. 12
Macrophages contribute to the activation of fibroblastic cells into myofibroblasts, which secrete collagen and contract the collagen matrix to acutely repair injured tissue. Persistent myofibroblast activation leads to the accumulation of fibrotic sc
Autor:
Monika Lodyga, Abby L. Olsen, Marielle Walraven, Rebecca G. Wells, Stellar Boo, Michelle Im, Grace Chau, Eric S. White, Boris Hinz, Anne Koehler, Franco Klingberg, Melissa L. Chow
Publikováno v:
Journal of Cell Science.
Dysregulated secretion and extracellular activation of TGF-β1 stimulates myofibroblasts to accumulate disordered and stiff extracellular matrix (ECM) leading to fibrosis. Fibronectin immobilizes latent TGF-β-binding protein-1 (LTBP-1) and thus stor
Autor:
Károly Fátyol, Matthew Rozycki, Maria Zena Miranda, Jessica Lam, Pam Speight, Monika Lodyga, Andras Kapus
Publikováno v:
Molecular Biology of the Cell
Myofibroblast transition from mesenchymal or epithelial precursors triggers loss of the primary cilium. In epithelial cells this requires contact injury and TGFβ and is mediated by Rac- and Smad3-dependent myosin phosphorylation. Thus the myofibrobl