Semaglutide reduces tumor burden in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH-HCC with advanced fibrosis

Autor: Henrik H. Hansen, Susanne Pors, Maja W. Andersen, Mogens Vyberg, Jacob Nøhr-Meldgaard, Malte Hasle Nielsen, Denise Oró, Martin Rønn Madsen, Monika Lewinska, Mathias B. Møllerhøj, Andreas Nygaard Madsen, Michael Feigh

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)

Abstract Non-alcoholic steatohepatitis (NASH) is emerging as a major cause of hepatocellular carcinoma (HCC), however, it is not resolved if compounds in late-stage clinical development for NASH may have additional therapeutic benefits in NASH-driven

Externí odkaz: https://doaj.org/article/6927b3ad4ca84f23baf16f380b108cdf

The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma

Autor: Monika Lewinska, PhD, Alvaro Santos-Laso, PhD, Enara Arretxe, PhD, Cristina Alonso, PhD, Ekaterina Zhuravleva, PhD, Raul Jimenez-Agüero, MD, PhD, Emma Eizaguirre, MD, PhD, María Jesús Pareja, MD, PhD, Manuel Romero-Gómez, MD, PhD, Marco Arrese Jimenez, MD, PhD, Malte P. Suppli, MD, PhD, Filip K. Knop, MD, PhD, Stine Karlsen Oversoe, MD, PhD, Gerda Elisabeth Villadsen, MD, PhD, Thomas Decaens, MD, PhD, Flair Jose Carrilho, MD, PhD, Claudia PMS de Oliveira, MD, PhD, Bruno Sangro, MD, PhD, Rocio I.R. Macias, MD, PhD, Jesus M. Banales, PhD, Jesper B. Andersen, PhD

Publikováno v: EBioMedicine, Vol 73, Iss , Pp 103661- (2021)

Background: Non-alcoholic fatty liver disease (NAFLD) is affecting more people globally. Indeed, NAFLD is a spectrum of metabolic dysfunctions that can progress to hepatocellular carcinoma (NAFLD-HCC). This development can occur in a non-cirrhotic li

Externí odkaz: https://doaj.org/article/a98663c5714b4b39a2da1a493b1539b3

Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma

Autor: Matteo Ramazzotti, Luca Viganò, Mirella Pastore, Maria Letizia Taddei, Monika Lewinska, Javier Cibella, Clelia Peano, Erica Pranzini, Luca Di Tommaso, Elena Sacco, Jessica Iorio, Paola Chiarugi, S. Madiai, Jesper B. Andersen, Chiara Raggi, Ivan Orlandi, B. Piombanti, Giovanni Di Maira, Margherita Correnti, N. Navari, Tiziano Lottini, Annarosa Arcangeli, Giulia Lori, Claudia Campani, Fabio Marra

Publikováno v: Raggi, C, Taddei, M L, Sacco, E, Navari, N, Correnti, M, Piombanti, B, Pastore, M, Campani, C, Pranzini, E, Iorio, J, Lori, G, Lottini, T, Peano, C, Cibella, J, Lewinska, M, Andersen, J B, di Tommaso, L, Viganò, L, Di Maira, G, Madiai, S, Ramazzotti, M, Orlandi, I, Arcangeli, A, Chiarugi, P & Marra, F 2021, ' Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma ', Journal of Hepatology, vol. 74, no. 6, pp. 1373-1385 . https://doi.org/10.1016/j.jhep.2020.12.031

BACKGROUND & AIMS: Little is known about the metabolic regulation of cancer stem cells (CSCs) in cholangiocarcinoma (CCA). We analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stemness in CCA.METHODS: Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef501d3fbda1682299d6ec0832b7ea5
https://doi.org/10.1016/j.jhep.2020.12.031

Therapeutic Rationale to Target Highly Expressed Aurora kinase A Conferring Poor Prognosis in Cholangiocarcinoma

Autor: Keun Soo Ahn, Lewis R. Roberts, Gang Chen, Xiwei Ding, Lei Wang, Guifang Xu, Yu Cao, Shanshan Shen, Xiaoping Zou, Helmut Friess, Monika Lewinska, Tianlu Huang, Bo Kong, Jesper B. Andersen, Chunyan Peng

Publikováno v: Ding, X, Huang, T, Peng, C, Ahn, K S, Andersen, J B, Lewinska, M, Cao, Y, Xu, G, Chen, G, Kong, B, Friess, H, Shen, S, Roberts, L R, Wang, L & Zou, X 2020, ' Therapeutic Rationale to Target Highly Expressed Aurora kinase A Conferring Poor Prognosis in Cholangiocarcinoma ', Journal of Cancer, vol. 11, no. 8, pp. 2241-2251 . https://doi.org/10.7150/jca.31989
Journal of Cancer

Background: Cholangiocarcinoma is a highly lethal neoplasm for which the currently available chemotherapeutic agents are suboptimal. Numerous studies show that alterations in expression of genes related to mitotic spindle and mitotic checkpoint are i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357010ef3e6cf4492c077678a66a491d
https://doi.org/10.7150/jca.31989

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

Autor: Lea Duwe, Patricia Munoz-Garrido, Monika Lewinska, Juan Lafuente-Barquero, Letizia Satriano, Dan Høgdall, Andrzej Taranta, Boye S. Nielsen, Awaisa Ghazal, Matthias S. Matter, Jesus M. Banales, Blanca I. Aldana, Yu-Tang Gao, Jens U. Marquardt, Lewis R. Roberts, Rui C. Oliveira, Jill Koshiol, Colm J. O'Rourke, Jesper B. Andersen

Publikováno v: Duwe, L, Munoz-Garrido, P, Lewinska, M, Lafuente-Barquero, J, Satriano, L, Høgdall, D, Taranta, A, Nielsen, B S, Ghazal, A, Matter, M S, Banales, J M, Aldana, B I, Gao, Y-T, Marquardt, J U, Roberts, L R, Oliveira, R C, Koshiol, J, O'Rourke, C J & Andersen, J B 2022, ' MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells ', Journal of Hepatology, vol. 78 . https://doi.org/10.1016/j.jhep.2022.10.012
Journal of Hepatology

Background & Aims: Cholangiocarcinoma (CCA) is a heterogeneous and lethal malignancy, the molecular origins of which remain poorly understood. MicroRNAs (miRs) target diverse signalling pathways, functioning as potent epigenetic regulators of transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e66c0650516d2ceadf1aaae8cfc9a5
https://curis.ku.dk/portal/da/publications/microrna27a3p-targets-foxo-signalling-to-induce-tumourlike-phenotypes-in-bile-duct-cells(e2e06416-2bd3-4e90-9573-ab895519c481).html