Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Monika Lachner"'
Autor:
Alexander Kohlmaier, Fabio Savarese, Monika Lachner, Joost Martens, Thomas Jenuwein, Anton Wutz
Publikováno v:
PLoS Biology, Vol 2, Iss 7, p E171 (2004)
We have elucidated the kinetics of histone methylation during X inactivation using an inducible Xist expression system in mouse embryonic stem (ES) cells. Previous reports showed that the ability of Xist to trigger silencing is restricted to an early
Externí odkaz:
https://doaj.org/article/a6db8abf1e7c4c67ba867d6f4b37109e
Autor:
Thomas Manke, Valentina Perrera, Johannes Popow, Borbala Gerle, Thomas Jenuwein, Nicholas Shukeir, Susanne Opravil, Michaela Pagani, Manuela Scaranaro, Aydan Bulut-Karslioglu, Suzanne van de Nobelen, Thomas Brabletz, Simone Meidhof, Monika Lachner, Inti A. De La Rosa-Velázquez
Publikováno v:
Nature Structural and Molecular Biology
Heterochromatin is important for genome integrity and stabilization of gene-expression programs. We have identified the transcription factors Pax3 and Pax9 as redundant regulators of mouse heterochromatin, as they repress RNA output from major satell
Autor:
Danny Reinberg, Inês Pinheiro, Mineo Kurokawa, Nicholas Shukeir, Gerhard Mittler, Christoph Fritzsch, Christel Genoud, Raphaël Margueron, Susumu Goyama, Monika Lachner, Michael Eisold, Florian Richter, Jinsook Son, Thomas Jenuwein
Publikováno v:
Cell
SummaryHeterochromatin serves important functions, protecting genome integrity and stabilizing gene expression programs. Although the Suv39h methyltransferases (KMTs) are known to ensure pericentric H3K9me3 methylation, the mechanisms that initiate a
Autor:
Roopsha Sengupta, Monika Lachner, Anja Ebert, Gunter Reuter, Gunnar Schotta, Kavitha Sarma, Danny Reinberg, Thomas Jenuwein
Publikováno v:
Genes & Development. 18:1251-1262
Histone lysine methylation is a central modification to mark functionally distinct chromatin regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric heterochromatin in mammals. Here we show that H4-K20 trimethylation is
Autor:
Arie P. Otte, Thijs Hendrix, Richard George Antonius Bernardus Sewalt, Dieter Schweizer, Martin Melcher, Monika Lachner, Karien M. Hamer, Mark Vargas, Jan L. den Blaauwen, Thomas Jenuwein
Publikováno v:
Molecular and Cellular Biology. 22:5539-5553
Polycomb group (PcG) proteins form multimeric chromatin-associated protein complexes that are involved in heritable repression of gene activity. Two distinct human PcG complexes have been characterized. The EED/EZH2 PcG complex utilizes histone deace
Autor:
Thomas Jenuwein, Jörn Walter, Aydan Bulut-Karslioglu, Monika Lachner, Carmen Galán, Maxim Barenboim, Georg E. Winter, Fidel Ramírez, Inti A. De La Rosa-Velázquez, Megumi Onishi-Seebacher, Borbala Gerle, Thomas Manke, Joost H.A. Martens, Bettina Engist, Julia Arand, Roderick J. O'Sullivan
Publikováno v:
Molecular Cell
Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP
Publikováno v:
Reversible Protein Acetylation: Novartis Foundation Symposium 259
Diverse post-translational modifications of histone N-termini represent an important epigenetic mechanism for the organization of chromatin structure and the regulation of gene activity. Within the last three years, great progress has been made in un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b302f648f4a71d76e8d7e9fb939114fe
https://doi.org/10.1002/0470862637.ch3
https://doi.org/10.1002/0470862637.ch3
Autor:
Joost H.A. Martens, Fabio Savarese, Alexander Kohlmaier, Monika Lachner, Anton Wutz, Thomas Jenuwein
Publikováno v:
PLoS Biology, Vol 2, Iss 7, p E171 (2004)
PLoS Biology
PLoS Biology
We have elucidated the kinetics of histone methylation during X inactivation using an inducible Xist expression system in mouse embryonic stem (ES) cells. Previous reports showed that the ability of Xist to trigger silencing is restricted to an early
Publikováno v:
Novartis Foundation symposium. 259
Diverse post-translational modifications of histone N-termini represent an important epigenetic mechanism for the organization of chromatin structure and the regulation of gene activity. Within the last three years, great progress has been made in un
Publikováno v:
Journal of cell science. 116(Pt 11)
Histone N-termini (tails) undergo diverse post-translational modifications, including acetylation, phosphorylation, methylation, ubiquitination and ADP-ribosylation ([van Holde, 1988][1]; [Wolffe, 1998][2]). The discoveries of enzymes that perform th