Výsledky vyhledávání - "Monika Kijanska"

In vivo characterization of the integration and vascularization of a silk-derived surgical scaffold

Autor: Nicole Lindenblatt, Vartan Kurtcuoglu, Pietro Giovanoli, Monika Kijanska, Anastasios Marmaras, Alicia Hegglin

Publikováno v: Journal of Plastic, Reconstructive & Aesthetic Surgery. 69:1141-1150

BACKGROUND The application of acellular matrices, biomaterials, and polymeric scaffolds in reconstructive surgery facilitates postsurgical tissue remodeling and is increasingly used clinically in order to improve tissue healing and implant coverage.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1777580f96718954c5f0b27656b2ce
https://doi.org/10.1016/j.bjps.2016.01.017

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Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

Autor: Paul Morgan, Mark Pilling, Jens M. Kelm, Alison J. Foster, Daniel Shienson, Dominic P. Williams, Claire Summers, Brian Middleton, Simon Ströbel, Simon Messner, Monika Kijanska, William R Proctor, Jennifer Vogt

Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d1d742f24415c0baa03aee347ea9ad
https://www.repository.cam.ac.uk/handle/1810/266637

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Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase

Autor: Daniel Papinski, Martina Schuschnig, Wolfgang Reiter, Larissa Wilhelm, Christopher A. Barnes, Alessio Maiolica, Isabella Hansmann, Thaddaeus Pfaffenwimmer, Monika Kijanska, Ingrid Stoffel, Sung Sik Lee, Andrea Brezovich, Jane Hua Lou, Benjamin E. Turk, Ruedi Aebersold, Gustav Ammerer, Matthias Peter, Claudine Kraft

Publikováno v: Molecular Cell
Molecular Cell, 53 (3)
Molecular cell
Europe PubMed Central

Summary Bulk degradation of cytoplasmic material is mediated by a highly conserved intracellular trafficking pathway termed autophagy. This pathway is characterized by the formation of double-membrane vesicles termed autophagosomes engulfing the subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc406bf169e73e6630921473836d424

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Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy

Autor: Isabella Hansmann, Claudine Kraft, Matthias Peter, Andrea Brezovich, Edyta Siergiejuk, Monika Kijanska, Sung Sik Lee, Ingrid Stoffel, Kay Hofmann, Eyal Kalie, Gustav Ammerer, Sharon A. Tooze, Giuseppe Semplicio, Mayanka Verma

Publikováno v: The EMBO Journal. 31:3691-3703

Autophagy is an intracellular trafficking pathway sequestering cytoplasm and delivering excess and damaged cargo to the vacuole for degradation. The Atg1/ULK1 kinase is an essential component of the core autophagy machinery possibly activated by bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b903f82cf831c7767c0bbdeddc9662d
https://doi.org/10.1038/emboj.2012.225

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Application of 3D liver microtissues for assessment of drug-induced liver injury (DILI) and for studying liver steatosis

Autor: Simon Messner, Patrick Guye, Tobias Strassfeld, Fabrice Müller, David A. Fluri, Monika Kijanska, Radina Kostadinova, Wolfgang Moritz

Publikováno v: Toxicology Letters. 280:S74-S75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9830bfaa35d84922f10e27c093580345
https://doi.org/10.1016/j.toxlet.2017.07.191

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The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein

Autor: Urszula Derewenda, P. Todd Stukenberg, Won-Chan Choi, Zygmunt S. Derewenda, Monika Kijanska, Eliza Żyłkiewicz

Publikováno v: The Journal of Cell Biology

Binding of the N terminus of Ndel1 to dynein facilitates microtubule self-organization in Ran-induced asters.
Ndel1 has been implicated in a variety of dynein-related processes, but its specific function is unclear. Here we describe an experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ec2c6aea3a53b1e4775bd9532512b9
https://doi.org/10.1083/jcb.201011142

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Activation of Atg1 kinase in autophagy by regulated phosphorylation

Autor: Claudine Kraft, Ilse Dohnal, Gustav Ammerer, Matthias Peter, Wolfgang Reiter, Ingrid Stoffel, Susanne Kaspar, Monika Kijanska

Publikováno v: Autophagy. 6:1168-1178

Autophagy is a highly regulated trafficking pathway that leads to selective degradation of cellular constituents such as protein aggregates and excessive and damaged organelles. Atg1 is an essential part of the core autophagic machinery, which trigge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d509e6ce834173afdb659fe98ee2b4ad
https://doi.org/10.4161/auto.6.8.13849

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