Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Monika Kandebo"'
Autor:
Nanyan Rena Zhang, Nathan G. Hatcher, Kim Ekroos, Komal Kedia, Monika Kandebo, Jacob N. Marcus, Sean M. Smith, Kevin P. Bateman, Daniel S. Spellman
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100218- (2022)
A major challenge of lipidomics is to determine and quantify the precise content of complex lipidomes to the exact lipid molecular species. Often, multiple methods are needed to achieve sufficient lipidomic coverage to make these determinations. Mult
Externí odkaz:
https://doaj.org/article/dab7af844e374932baf5dd7f758560ce
Autor:
Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A. Gretzula, Monika Kandebo, Dawn Toolan, Nathan G. Hatcher, Lei Ma, Wei Lemaire, Gregory C. Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L. Watt, James Mulhearn, Mark Fraley, Robert E. Drolet, Jacob N. Marcus, Sean M. Smith
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105507- (2021)
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSp
Externí odkaz:
https://doaj.org/article/5bb119e476704557a1fe920f9ef43979
Autor:
Nicole K Polinski, Terina N Martinez, Alexander Gorodinsky, Ralph Gareus, Michael Sasner, Mark Herberth, Robert Switzer, Syed O Ahmad, Mali Cosden, Monika Kandebo, Robert E Drolet, Peter D Buckett, Weisong Shan, Yi Chen, Lee J Pellegrino, Gregory D Ellsworth, Leo B Dungan, Warren D Hirst, Sean W Clark, Kuldip D Dave
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252325 (2021)
Multiple mutations have been described in the human GBA1 gene, which encodes the lysosomal enzyme beta-glucocerebrosidase (GCase) that degrades glucosylceramide and is pivotal in glycosphingolipid substrate metabolism. Depletion of GCase, typically b
Externí odkaz:
https://doaj.org/article/294b88f9cc54498d84ccf437a6bd2775
Autor:
Anthony J. Roecker, Kathy M. Schirripa, H. Marie Loughran, Ling Tong, Tao Liang, Kerry L. Fillgrove, Yuhsin Kuo, Kelly Bleasby, Hannah Collier, Michael D. Altman, Melissa C. Ford, Robert E. Drolet, Mali Cosden, Sarah Jinn, Nathan G. Hatcher, Lihang Yao, Monika Kandebo, Joshua D. Vardigan, Rosemarie B. Flick, Xiaomei Liu, Christina Minnick, Laura A. Price, Marla L. Watt, Wei Lemaire, Christine Burlein, Gregory C. Adam, Lauren A. Austin, Jacob N. Marcus, Sean M. Smith, Mark E. Fraley
Publikováno v:
ACS Medicinal Chemistry Letters. 14:146-155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a75f2713f77a436a3c71e753c7d659
https://doi.org/10.1021/acsmedchemlett.2c00441
https://doi.org/10.1021/acsmedchemlett.2c00441
Autor:
Mark E. Layton, Jeffrey C. Kern, Timothy J. Hartingh, William D. Shipe, Izzat Raheem, Monika Kandebo, Robert P. Hayes, Sarah Huszar, Donnie Eddins, Bennett Ma, Joy Fuerst, Gordon K. Wollenberg, Jing Li, Jeff Fritzen, Georgia B. McGaughey, Jason M. Uslaner, Sean M. Smith, Paul J. Coleman, Christopher D. Cox
Publikováno v:
Journal of Medicinal Chemistry. 66:1157-1171
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34d1b1b6ca3f79f9d512404321891d5
https://doi.org/10.1021/acs.jmedchem.2c01521
https://doi.org/10.1021/acs.jmedchem.2c01521
Autor:
Casey L. Mahoney-Crane, Megha Viswanathan, Dreson Russell, Rachel A.C. Curtiss, Jennifer Freire, Sai Sumedha Bobba, Sean D. Coyle, Monika Kandebo, Lihang Yao, Bang-Lin Wan, Nathan G. Hatcher, Sean M. Smith, Jacob N. Marcus, Laura A. Volpicelli-Daley
Publikováno v:
The Journal of Neuroscience. 43:501-521
The most common genetic risk factor for Parkinson's disease (PD) is heterozygous mutationsGBA1, which encodes for the lysosomal enzyme, glucocerebrosidase. Reduced glucocerebrosidase activity associates with an accumulation of abnormal α-synuclein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e53fa31184f65b618e50145e3c5d29
https://doi.org/10.1523/jneurosci.0680-22.2022
https://doi.org/10.1523/jneurosci.0680-22.2022
Autor:
Sean Smith, Jason Uslaner, Monika Kandebo, Eric Hostetler, Izzat Raheem, Mark Layton, Liza Gantert, Kerry Riffel, Christopher Cox, Sauzanne Khalilieh, Inge De Lepeleire, Guy Bormans, Marleen Depré, Jan de Hoon, Koen Van Laere
Publikováno v:
Biological Psychiatry. 91:S309-S310
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be24d4d168d91f8a0c44a7922f62e58c
https://doi.org/10.1016/j.biopsych.2022.02.783
https://doi.org/10.1016/j.biopsych.2022.02.783
Autor:
Lee Pellegrino, Monika Kandebo, Nicole K. Polinski, Mark Herberth, Leo B. Dungan, Robert Switzer, Gregory D. Ellsworth, Sean W. Clark, Alexander Gorodinsky, Robert E. Drolet, Peter D. Buckett, Mali Cosden, Michael Sasner, Ralph Gareus, Syed Omar Ahmad, Weisong Shan, Terina N. Martinez, Kuldip D. Dave, Warren D. Hirst, Yi Chen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252325 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252325 (2021)
Multiple mutations have been described in the human GBA1 gene, which encodes the lysosomal enzyme beta-glucocerebrosidase (GCase) that degrades glucosylceramide and is pivotal in glycosphingolipid substrate metabolism. Depletion of GCase, typically b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5768efebed44f52b94d2247e7ec2bf9
http://europepmc.org/articles/PMC8189458
http://europepmc.org/articles/PMC8189458
Autor:
Marla L. Watt, Sarah Jinn, Nathan G. Hatcher, Lei Ma, Mali Cosden, Monika Kandebo, Christine Burlein, Christina Minnick, Mark E. Fraley, Cheryl A. Gretzula, Wei Lemaire, Rose B. Flick, Sean M. Smith, James Mulhearn, Gregory C. Adam, Jacob Marcus, Robert E. Drolet, Dawn Toolan, Lihang Yao
Publikováno v:
Neurobiology of Disease, Vol 159, Iss, Pp 105507-(2021)
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cd5da06600d31f6c7bb67bb7f45f07
https://doi.org/10.1016/j.nbd.2021.105507
https://doi.org/10.1016/j.nbd.2021.105507
Autor:
Rhonda Roberts, Renee C. Gentzel, Jason M. Uslaner, Amy Jo Koser, Sean M. Smith, John J. Renger, Monika Kandebo, Dawn Toolan, James C. Hershey
Publikováno v:
Neuropharmacology. 99:256-263
Phosphodiesterase 10A (PDE10A) has garnered attention as a potential therapeutic target for schizophrenia due to its prominent striatal expression and ability to modulate striatal signaling. The present study used the selective PDE10A inhibitor MP-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ff51c080ece26eeb0c8c932c078f94
https://doi.org/10.1016/j.neuropharm.2015.05.024
https://doi.org/10.1016/j.neuropharm.2015.05.024