Overexpression of the HECT ubiquitin ligase PfUT prolongs the intraerythrocytic cycle and reduces invasion efficiency of Plasmodium falciparum

Autor: Cecilia P. Sanchez, Marek Cyrklaff, Michael Lanzer, Monika Jankowska-Döllken

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)

The glms ribozyme system has been used as an amenable tool to conditionally control expression of genes of interest. It is generally assumed that insertion of the ribozyme sequence does not affect expression of the targeted gene in the absence of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8214cd5e2358e3af3c3b81ded45a496
https://pubmed.ncbi.nlm.nih.gov/31797898

Phosphomimetic substitution at Ser-33 of the chloroquine resistance transporter PfCRT reconstitutes drug responses in Plasmodium falciparum

Autor: Michael Lanzer, Cecilia P. Sanchez, Daniel Ayoub, Christine Schaeffer-Reiss, Britta Nyboer, Monika Jankowska-Döllken, Gabrielle Planelles, Sonia Moliner Cubel

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (34), pp.12766-12778. ⟨10.1074/jbc.RA119.009464⟩

International audience; The chloroquine resistance transporter PfCRT of the human malaria parasite Plasmodium falciparum confers resistance to the former first-line antimalarial drug chloroquine, and it modulates the responsiveness to a wide range of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae4564f6f44872e6a13fc0d3853b15b
https://hal.archives-ouvertes.fr/hal-02470336