Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Monika Fuxreiter"'
Autor:
Tommaso Amico, Samuel Toluwanimi Dada, Andrea Lazzari, Michaela Brezinova, Antonio Trovato, Michele Vendruscolo, Monika Fuxreiter, Amos Maritan
Publikováno v:
eLife, Vol 13 (2024)
Many proteins have been recently shown to undergo a process of phase separation that leads to the formation of biomolecular condensates. Intriguingly, it has been observed that some of these proteins form dense droplets of sizeable dimensions already
Externí odkaz:
https://doaj.org/article/cef68681e44c466699c25c0ea405e260
Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis
Autor:
Mónika Gönczi, João M. C. Teixeira, Susana Barrera-Vilarmau, Laura Mediani, Francesco Antoniani, Tamás Milán Nagy, Krisztina Fehér, Zsolt Ráduly, Viktor Ambrus, József Tőzsér, Endre Barta, Katalin E. Kövér, László Csernoch, Serena Carra, Monika Fuxreiter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Mef2D context-dependent higher-order assembly controls simultaneous interactions with the basal machinery and the myogenic factors to activate distinct gene expression programs for muscle lineage development.
Externí odkaz:
https://doaj.org/article/c56baa30ca0d43f69074104dd3ee4173
Autor:
Michele Vendruscolo, Monika Fuxreiter
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In this review, the authors define protein condensation diseases as conditions caused by aberrant liquid-like or solid-like states of proteins, and describe opportunities for therapeutic interventions to restore the normal phase behaviour of proteins
Externí odkaz:
https://doaj.org/article/5a1a0361c601474cb9440cce7606f01a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/d6fa5501e98c4994974ff28f09b4b0fd
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007864 (2020)
Interactions between disordered proteins involve a wide range of changes in the structure and dynamics of the partners involved. These changes can be classified in terms of binding modes, which include disorder-to-order (DO) transitions, when protein
Externí odkaz:
https://doaj.org/article/6344c5a22233420cac8362bb072b923d
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 92 (2022)
Biomolecular condensates challenge the classical concepts of molecular recognition. The variable composition and heterogeneous conformations of liquid-like protein droplets are bottlenecks for high-resolution structural studies. To obtain atomistic i
Externí odkaz:
https://doaj.org/article/03b606d1c86548d88123b506bac13ee7
Autor:
Mauris C. Nnamani, Soumya Ganguly, Eric M. Erkenbrack, Vincent J. Lynch, Laura S. Mizoue, Yingchun Tong, Heather L. Darling, Monika Fuxreiter, Jens Meiler, Günter P. Wagner
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2097-2108 (2016)
Transcription factors (TFs) play multiple roles in development. Given this multifunctionality, it has been assumed that TFs are evolutionarily highly constrained. Here, we investigate the molecular mechanisms for the origin of a derived functional in
Externí odkaz:
https://doaj.org/article/5f16ba8789c145e3a7460853e1958712
Autor:
Monika Fuxreiter
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8615 (2020)
Disordered proteins often act as interaction hubs in cellular pathways, via the specific recognition of a distinguished set of partners. While disordered regions can adopt a well-defined conformation upon binding, the coupled folding to binding model
Externí odkaz:
https://doaj.org/article/3d815d3e31db448faf8cbf10af0cf002
Autor:
Robin van der Lee, Benjamin Lang, Kai Kruse, Jörg Gsponer, Natalia Sánchez de Groot, Martijn A. Huynen, Andreas Matouschek, Monika Fuxreiter, M. Madan Babu
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1832-1844 (2014)
Precise control of protein turnover is essential for cellular homeostasis. The ubiquitin-proteasome system is well established as a major regulator of protein degradation, but an understanding of how inherent structural features influence the lifetim
Externí odkaz:
https://doaj.org/article/90823de7690e4e718d79b335dde386a6
Autor:
Monika Fuxreiter
Publikováno v:
Molecules, Vol 23, Iss 11, p 3008 (2018)
The deterministic sequence → structure → function relationship is not applicable to describe how proteins dynamically adapt to different cellular conditions. A stochastic model is required to capture functional promiscuity, redundant sequence mot
Externí odkaz:
https://doaj.org/article/161ffb2696e5436080fa653368720bf7