Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

Autor: Monika E Dolega, Sylvain Monnier, Benjamin Brunel, Jean-François Joanny, Pierre Recho, Giovanni Cappello

Publikováno v: eLife, Vol 10 (2021)

Imposed deformations play an important role in morphogenesis and tissue homeostasis, both in normal and pathological conditions. To perceive mechanical perturbations of different types and magnitudes, tissues need appropriate detectors, with a compli

Externí odkaz: https://doaj.org/article/31ceeb51a910491db7ea54288098f188

Extra-cellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

Autor: Monika E. Dolega, Giovanni Cappello, Sylvain Monnier, Pierre Recho, Benjamin Brunel, Jean-François Joanny

Publikováno v: eLife
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.63258⟩
eLife, Vol 10 (2021)

International audience; Imposed deformations play an important role in morphogenesis and tissue homeostasis, both in normal and pathological conditions. To perceive mechanical perturbations of different types and magnitudes, tissues need appropriate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79564b20c0a21b6d9db31f16ced7498d
https://hal.archives-ouvertes.fr/hal-03015345v2/document

Direction of epithelial folding defines impact of mechanical forces on epithelial state

Autor: Slawomir Blonski, Julien Aureille, Sara Badawi, Damian Zaremba, Lydia Pernet, Alexei Grichine, Sandrine Fraboulet, Piotr M. Korczyk, Pierre Recho, Christophe Guilluy, Monika E. Dolega

Publikováno v: Developmental cell. 56(23)

Cell shape dynamics during development is tightly regulated and coordinated with cell fate determination. Triggered by an interplay between biochemical and mechanical signals, epithelia form complex tissues by undergoing coordinated cell shape change

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da591874a629b74b0ecef98c9972e6e
https://pubmed.ncbi.nlm.nih.gov/34875221

Measuring cell displacements in opaque tissues: dynamic light scattering in the multiple scattering regime

Autor: Romain Pierrat, Vincent Levy, Benjamin Brunel, Arnaud Millet, Antoine Delon, Monika E. Dolega, Giovanni Cappello

Publikováno v: Biomedical optics express
Biomedical optics express, 2020, 11 (4), pp.2277. ⟨10.1364/BOE.388360⟩
Biomedical optics express, Optical Society of America-OSA Publishing, 2020, 11 (4), pp.2277. ⟨10.1364/BOE.388360⟩

International audience; Coherent light scattered by tissues brings structural and dynamic information, at depth, that standard imaging techniques cannot reach. Dynamics of cells or sub-cellular elements can be measured thanks to dynamic light scatter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9bd24248851475f9c4bd2d24851819
https://doi.org/10.1364/BOE.388360

Mechanical behavior of multi-cellular spheroids under osmotic compression

Autor: Jean-François Joanny, M. Le Goff, Pierre Recho, Giuseppe Zurlo, M. Greda, Giovanni Cappello, Claude Verdier, Monika E. Dolega

Publikováno v: Journal of the Mechanics and Physics of Solids
Journal of the Mechanics and Physics of Solids, Elsevier, 2020, pp.104205. ⟨10.1016/j.jmps.2020.104205⟩
Journal of the Mechanics and Physics of Solids, Elsevier, In press, ⟨10.1016/j.jmps.2020.104205⟩
Journal of the Mechanics and Physics of Solids, Elsevier, inPress, ⟨10.1016/j.jmps.2020.104205⟩

International audience; The internal and external mechanical environment plays an important role in tumorogenesis. As a proxy of an avas-cular early state tumor, we use multicellular spheroids, a composite material made of cells, extracellular matrix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265057606765a8b83391b30f05fa8877
https://doi.org/10.1016/j.jmps.2020.104205