Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Monika Dohse"'
Autor:
Axel Witt, Tatiana Goncharov, Yujung Michelle Lee, Matthias Kist, Monika Dohse, Jeff Eastham, Debra Dugger, Kim Newton, Joshua D. Webster, Domagoj Vucic
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-8 (2023)
Abstract XIAP is a caspase-inhibitory protein that blocks several cell death pathways, and mediates proper activation of inflammatory NOD2-RIP2 signaling. XIAP deficiency in patients with inflammatory diseases such as Crohn’s disease, or those need
Externí odkaz:
https://doaj.org/article/42740dc575bd483ca8f1e15a17296b06
Autor:
Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hötzel, Ben Chih
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105969- (2023)
Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates. As DA
Externí odkaz:
https://doaj.org/article/f3994bb352724f55b0845dad814ba7b9
Autor:
Daniel P. Dever, Samantha G. Scharenberg, Joab Camarena, Eric J. Kildebeck, Joseph T. Clark, Renata M. Martin, Rasmus O. Bak, Yuming Tang, Monika Dohse, Johannes A. Birgmeier, Karthik A. Jagadeesh, Gill Bejerano, Ann Tsukamoto, Natalia Gomez-Ospina, Nobuko Uchida, Matthew H. Porteus
Publikováno v:
iScience, Vol 15, Iss , Pp 524-535 (2019)
Summary: Human neural stem cells (NSCs) offer therapeutic potential for neurodegenerative diseases, such as inherited monogenic nervous system disorders, and neural injuries. Gene editing in NSCs (GE-NSCs) could enhance their therapeutic potential. W
Externí odkaz:
https://doaj.org/article/2fa9e32ecf84457fb9e04fdb55b3dba9
Autor:
Ben Korin, Shimrit Avraham, Reuben Moncada, Terence Ho, Mayra Cruz Tleugabulova, Hari Menon, Spyros Darmanis, Yuxin Liang, Zora Modrusan, Cecile Chalouni, Charles Victoria, Linda Rangell, Charles Havnar, Will Ewart, Charles Jones, Jian Jiang, Debra Dunlap, Monika Dohse, Andrew McKay, Joshua D Webster, Steffen Durinck, Andrey S Shaw
The kidney is a complex organ that governs many physiological parameters. It is roughly divided into three parts, the renal pelvis, medulla, and cortex. Covering the cortex is the renal capsule, a serosal tissue that provides protection and forms a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::814df12cc71dbee0413511301194ee45
https://doi.org/10.1101/2023.05.11.540033
https://doi.org/10.1101/2023.05.11.540033
Autor:
Avi Ashkenazi, Peter Walter, Hartmut Koeppen, Joachim Rudolph, Zora Modrusan, Margaret Solon, Monika Dohse, Kathryn Mesh, Lisa M. Crocker, Klara Totpal, Mark Merchant, Ehud Segal, David Kan, David A. Lawrence, Anna Shemorry, Scot A. Marsters, Thomas D. Wu, Ofer Guttman, Mike Reichelt, Adrien Le Thomas, Jonathan M. Harnoss
Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic reticulum (ER) stress caused by cellular oncogene activation and a hostile tumor microenvironment (TME). The key UPR sensor IRE1α resides in the ER and deploys a cytopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f449b5b365bd1638a42e0af1a7c7a357
https://doi.org/10.1158/0008-5472.c.6511463.v1
https://doi.org/10.1158/0008-5472.c.6511463.v1
Autor:
Avi Ashkenazi, Peter Walter, Hartmut Koeppen, Joachim Rudolph, Zora Modrusan, Margaret Solon, Monika Dohse, Kathryn Mesh, Lisa M. Crocker, Klara Totpal, Mark Merchant, Ehud Segal, David Kan, David A. Lawrence, Anna Shemorry, Scot A. Marsters, Thomas D. Wu, Ofer Guttman, Mike Reichelt, Adrien Le Thomas, Jonathan M. Harnoss
Supplementary Data, including Supplementary Materials and Methods, References for Supplementary Data, and Figs. S1 to S5 including Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2debaf8226a89d41e2b51ea1e40f553d
https://doi.org/10.1158/0008-5472.22423295
https://doi.org/10.1158/0008-5472.22423295
Autor:
Joshua D. Webster, Debra L. Dugger, Vishva M. Dixit, László G. Kőműves, Allie Maltzman, Merone Roose-Girma, Kim Newton, Monika Dohse, Katherine E. Wickliffe
Publikováno v:
Nature. 574:428-431
The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a RIPK3- and MLKL-dependent manner during embryogenesis1-3. In humans, caspase-8 deficiency is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bd9c2ba3ded4e067b590881a3c6c4f1
https://doi.org/10.1038/s41586-019-1548-x
https://doi.org/10.1038/s41586-019-1548-x
Autor:
Alexander D, Gitlin, Klaus, Heger, Alexander F, Schubert, Rohit, Reja, Donghong, Yan, Victoria C, Pham, Eric, Suto, Juan, Zhang, Youngsu C, Kwon, Emily C, Freund, Jing, Kang, Anna, Pham, Roger, Caothien, Natasha, Bacarro, Trent, Hinkle, Min, Xu, Brent S, McKenzie, Benjamin, Haley, Wyne P, Lee, Jennie R, Lill, Merone, Roose-Girma, Monika, Dohse, Joshua D, Webster, Kim, Newton, Vishva M, Dixit
Publikováno v:
Nature. 587(7833)
Mutations in the death receptor FAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32a6433d04a9fdc12527bc4bd484234e
https://pubmed.ncbi.nlm.nih.gov/33106621
https://pubmed.ncbi.nlm.nih.gov/33106621
Autor:
Thomas D. Wu, Margaret Solon, Zora Modrusan, Monika Dohse, David A. Lawrence, Jonathan M. Harnoss, Peter Walter, David Kan, Ofer Guttman, Mike Reichelt, Ehud Segal, Adrien Le Thomas, Anna Shemorry, Avi Ashkenazi, Joachim Rudolph, Mark Merchant, Lisa Crocker, Hartmut Koeppen, Scot A. Marsters, Kathryn Mesh, Klara Totpal
Publikováno v:
Cancer Res
Cancer research, vol 80, iss 11
Cancer research, vol 80, iss 11
Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic reticulum (ER) stress caused by cellular oncogene activation and a hostile tumor microenvironment (TME). The key UPR sensor IRE1α resides in the ER and deploys a cytopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8a8fd2e09a51b1483052d08abd40cd
https://europepmc.org/articles/PMC7272310/
https://europepmc.org/articles/PMC7272310/
Autor:
Kim, Newton, Katherine E, Wickliffe, Debra L, Dugger, Allie, Maltzman, Merone, Roose-Girma, Monika, Dohse, László, Kőműves, Joshua D, Webster, Vishva M, Dixit
Publikováno v:
Nature. 574(7778)
The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a RIPK3- and MLKL-dependent manner during embryogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5df8554e0e5aa0ff534e73974ce1e101
https://pubmed.ncbi.nlm.nih.gov/31511692
https://pubmed.ncbi.nlm.nih.gov/31511692