Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Monika Anton"'
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1397-1409 (2013)
Lipoxygenases (LOX) have been implicated in biosynthesis of pro- and anti-inflammatory mediators, and a previous report suggested compromised leukotriene signaling in H. neanderthalensis. To search for corresponding differences in leukotriene biosynt
Externí odkaz:
https://doaj.org/article/99a58b7e352c44dbac91c80c3b687ab4
Autor:
Thomas Horn, Kumar Reddy Kakularam, Monika Anton, Constanze Richter, Pallu Reddanna, Hartmut Kuhn
Publikováno v:
Redox Biology, Vol 1, Iss 1, Pp 566-577 (2013)
Mammalian lipoxygenases play a role in normal cell development and differentiation but they have also been implicated in the pathogenesis of cardiovascular, hyperproliferative and neurodegenerative diseases. As lipid peroxidizing enzymes they are inv
Externí odkaz:
https://doaj.org/article/abcbe4f4dcdf424e8c6889e3289c51e6
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1397-1409 (2013)
Lipoxygenases (LOX) have been implicated in biosynthesis of pro- and anti-inflammatory mediators, and a previous report suggested compromised leukotriene signaling in H. neanderthalensis. To search for corresponding differences in leukotriene biosynt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab69249bf69c2a35cc63b15ba5f284e
http://www.sciencedirect.com/science/article/pii/S0022227520421765
http://www.sciencedirect.com/science/article/pii/S0022227520421765
Autor:
Hartmut Kühn, Aparoy Polymarasetty, Katharina Hofheinz, Thomas Horn, Pallu Reddanna, Susan Adel, Monika Anton, Kumar Reddy Kakularam
Publikováno v:
Archives of Biochemistry and Biophysics. 530:40-47
5-Lipoxygenase (ALOX5) is a key enzyme in biosynthesis of pro-inflammatory leukotrienes whereas 15-lipoxygenases (ALOX15) have been implicated in the formation of pro-resolving eicosanoids (lipoxins, resolvins). Although mammalian LOX-isoforms share
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20699777cb65d6c854c586bf1ccf5789
https://doi.org/10.1016/j.abb.2012.11.015
https://doi.org/10.1016/j.abb.2012.11.015
Autor:
Hartmut Kühn, Jana Roffeis, Matthias Walther, Katharina Hofheinz, Monika Anton, Pallu Reddanna, Christian Jansen, Robert Vogel
Publikováno v:
Journal of Biological Chemistry. 286:37804-37812
Animal lipoxygenases (LOXs) are classified according to their specificity of arachidonic acid oxygenation, and previous sequence alignments suggested that S-LOXs contain a conserved Ala at a critical position at the active site but R-LOXs carry a Gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4efdb7a3a7b0d4a98177969a616ebdc
https://doi.org/10.1074/jbc.m111.259242
https://doi.org/10.1074/jbc.m111.259242
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:1072-1076
Objectives— The mouse strain CON6, which was generated by breeding athero-resistant CAST mice into an athero-susceptible B6 background, exhibits almost complete resistance to atherosclerosis. An athero-resistance gene cluster has been localized at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817385ac942fdfa84d55f69bd4b02666
https://doi.org/10.1161/01.atv.0000074167.01184.48
https://doi.org/10.1161/01.atv.0000074167.01184.48
Publikováno v:
Journal of Biological Chemistry. 276:773-779
Mammalian lipoxygenases constitute a heterogeneous family of lipid-peroxidizing enzymes, and the various isoforms are categorized with respect to their positional specificity of arachidonic acid oxygenation into 5-, 8-, 12-, and 15-lipoxygenases. Str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90db3543b9bfa2504c22e1216a5dea9b
https://doi.org/10.1074/jbc.m005114200
https://doi.org/10.1074/jbc.m005114200
Publikováno v:
Biochemistry. 39:14515-14521
The positional specificity of arachidonic acid oxygenation is currently the decisive parameter for classification of lipoxygenases. Although the mechanistic basis of lipoxygenase specificity is not completely understood, sequence determinants for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e5e14c9a7e0b8b26de9ed94b0ff0e6
https://doi.org/10.1021/bi001447n
https://doi.org/10.1021/bi001447n
Publikováno v:
Protein Expression and Purification. 19:403-410
15-Lipoxygenases and phospholipid hydroperoxide glutathione peroxidases are counterparts in the metabolism of hydroperoxy lipids and a balanced regulation of both enzymes is essential for normal cell function. Glutathione peroxidases contain selenocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c8e1136355a811e737707f040d87d9
https://doi.org/10.1006/prep.2000.1262
https://doi.org/10.1006/prep.2000.1262
Autor:
Michelle F. Browner, Hartmut Kühn, Monika Anton, Robert J. Fletterick, Sabine Borngräber, Sarah A. Gillmor, Christa Gerth
Publikováno v:
Journal of Biological Chemistry. 274:37345-37350
Previous mutagenesis studies along with molecular modeling using the x-ray coordinates of the rabbit 15-lipoxygenase have led to the suggestion that the size of the substrate binding pocket may play an essential role in determining the oxygenation sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1f62956d781ad10caeb2de25f317da
https://doi.org/10.1074/jbc.274.52.37345
https://doi.org/10.1074/jbc.274.52.37345