Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Monika A. Eiva"'
Autor:
Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endo
Externí odkaz:
https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b
Publikováno v:
Eur J Immunol
The detection of tumor-specific T cells in solid tumors is integral to the interrogation of endogenous antitumor responses and to the advancement of downstream therapeutic applications, such as checkpoint immunotherapy and adoptive cell transfer. A n
Autor:
Katherine D Cummins, Arjun Gupta, Ofrat Beyar-Katz, Ye Li, Paramita Chatterjee, Linda Kippner, Olga Shestova, Monika A Eiva, January Salas-Mckee, Carolyn Yeago, Krishnendu Roy, Saar Gill
Publikováno v:
Blood. 140:7415-7416
Autor:
Adam A. Kraya, Kara N. Maxwell, Monika A. Eiva, Bradley Wubbenhorst, John Pluta, Michael Feldman, Anupma Nayak, Daniel J. Powell, Susan M. Domchek, Robert H. Vonderheide, Katherine L. Nathanson
Publikováno v:
JCO Precis Oncol
PURPOSE Ovarian cancers can exhibit a prominent immune infiltrate, but clinical trials have not demonstrated substantive response rates to immune checkpoint blockade monotherapy. We aimed to understand genomic features associated with immunogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ae71ef6f172ec085d7f17999151dc2
https://europepmc.org/articles/PMC8982238/
https://europepmc.org/articles/PMC8982238/
Autor:
Anže Smole, Alexander Benton, Mathilde A. Poussin, Monika A. Eiva, Claudia Mezzanotte, Barbara Camisa, Beatrice Greco, Prannda Sharma, Nicholas G. Minutolo, Falon Gray, Adham S. Bear, Miren L. Baroja, Casey Cummins, Chong Xu, Francesca Sanvito, Andrea Lang Goldgewicht, Tatiana Blanchard, Alba Rodriguez-Garcia, Michael Klichinsky, Chiara Bonini, Carl H. June, Avery D. Posey, Gerald P. Linette, Beatriz M. Carreno, Monica Casucci, Daniel J. Powell
Publikováno v:
Cancer cell. 40(12)
Despite the success of CAR-T cell cancer immunotherapy, challenges in efficacy and safety remain. Investigators have begun to enhance CAR-T cells with the expression of accessory molecules to address these challenges. Current systems rely on constitu
Autor:
Daniel J. Powell, Roddy S. O’Connor, Nicholas G. Minutolo, Rachel C. Lynn, Lauren C. Shaw, Victoria Casado-Medrano, Mathilde Poussin, Takami Matsuyama, Alba Rodriguez-Garcia, Monika A. Eiva, Gonzalo Lopez
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous and plastic cell components of the TME which can either promote tumor progression
Autor:
Monika A. Eiva, George Coukos, Marie Christine Wulff Westergaard, Marie-Agnès Doucey, Christopher Neal, Fabrizio Benedetti, Victor Anstett, Aspram Minasyan, Inge Marie Svane, Alizée J. Grimm, Janos L. Tanyi, Peter K. Sorger, Periklis G. Foukas, Kathleen T. Montone, Amandine Moriot, Mauro Delorenzi, Riccardo Turrini, Wilson Castro, Santiago J. Carmona, Kalliopi Ioannidou, Sylvie Rusakiewicz, Anniina Färkkilä, Connor A. Jacobson, Denarda Dangaj Laniti, David Barras, Lana E. Kandalaft, Daniel J. Powell, Alexandre Wicky, Olivier Michielin, Noémie Fahr, Isaac Crespo, Jaikumar Duraiswamy, Vincent Zoete, Raphael Genolet, Stephanie Renaud-Tissot, Julia Casado
Publikováno v:
Cancer Cell
Cell Mol Immunol
Cell Mol Immunol
The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer we show that tumor-specific CD8(+) TIL accumulate in tumor islets, where they engage antig