Common genetic determinants of intraocular pressure and primary open-angle glaucoma.

Autor: Leonieke M E van Koolwijk, Wishal D Ramdas, M Kamran Ikram, Nomdo M Jansonius, Francesca Pasutto, Pirro G Hysi, Stuart Macgregor, Sarah F Janssen, Alex W Hewitt, Ananth C Viswanathan, Jacoline B ten Brink, S Mohsen Hosseini, Najaf Amin, Dominiek D G Despriet, Jacqueline J M Willemse-Assink, Rogier Kramer, Fernando Rivadeneira, Maksim Struchalin, Yurii S Aulchenko, Nicole Weisschuh, Matthias Zenkel, Christian Y Mardin, Eugen Gramer, Ulrich Welge-Lüssen, Grant W Montgomery, Francis Carbonaro, Terri L Young, DCCT/EDIC Research Group, Céline Bellenguez, Peter McGuffin, Paul J Foster, Fotis Topouzis, Paul Mitchell, Jie Jin Wang, Tien Y Wong, Monika A Czudowska, Albert Hofman, Andre G Uitterlinden, Roger C W Wolfs, Paulus T V M de Jong, Ben A Oostra, Andrew D Paterson, Wellcome Trust Case Control Consortium, David A Mackey, Arthur A B Bergen, André Reis, Christopher J Hammond, Johannes R Vingerling, Hans G Lemij, Caroline C W Klaver, Cornelia M van Duijn

Publikováno v: PLoS Genetics, Vol 8, Iss 5, p e1002611 (2012)

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic factors which determine IOP are largely unknown. We performed a genome-wide association stud

Externí odkaz: https://doaj.org/article/2c3a0536b8874168b6cf89e7e4f94eda

A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14

Autor: Abbas M Solouki, Aaron Isaacs, Paulus T. V. M. de Jong, David A. Mackey, Leonieke M E van Koolwijk, M. Kamran Ikram, Najaf Amin, Jacqueline J. M. Willemse-Assink, Albert Hofman, Christopher J Hammond, Cornelia M. van Duijn, André G. Uitterlinden, Frans C. C. Riemslag, Yurii S. Aulchenko, Lintje Ho, Wishal D. Ramdas, Fernando Rivadeneira, Sigrid M. A. Swagemakers, Monika A. Czudowska, Virginie J. M. Verhoeven, Dominiek D. G. Despriet, Rogier Kramer, Annemieke J.M.H. Verkerk, Terri L. Young, Pirro G. Hysi, Arthur A.B. Bergen, Ben A. Oostra, Robert W A M Kuijpers, Gabriel van Rij, Johannes R. Vingerling, Theo G. M. F. Gorgels, Maksim Struchalin, Andy A.L.J. van Oosterhout, Tim D. Spector, Caroline C W Klaver

Publikováno v: Nature Genetics
Nature Genetics; Vol 42
Nature Genetics, 42(10), 897-901. Nature Publishing Group
Nature genetics, 42(10), 897-+. Nature Publishing Group
Nature Genetics, 42(10), 897
Nature Genetics, 42, 897-901. Nature Publishing Group

Refractive errors are the most common ocular disorders worldwide and may lead to blindness. Although this trait is highly heritable, identification of susceptibility genes has been challenging. We conducted a genome-wide association study for refract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c751405c3b19e0185010a2ae17c4c8d