Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Monika A, Myszczynska"'
Autor:
Beatriz G. Perez-Nievas, Louisa Johnson, Paula Beltran-Lobo, Martina M. Hughes, Luciana Gammallieri, Francesca Tarsitano, Monika A. Myszczynska, Irina Vazquez-Villasenor, Maria Jimenez-Sanchez, Claire Troakes, Stephen B. Wharton, Laura Ferraiuolo, Wendy Noble
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Pathological interactions between β-amyloid (Aβ) and tau drive synapse loss and cognitive decline in Alzheimer’s disease (AD). Reactive astrocytes, displaying altered functions, are also a prominent feature of AD brain. This l
Externí odkaz:
https://doaj.org/article/d262341bcc2d4dd5ae59b2b8156cdf4d
Autor:
Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causing
Externí odkaz:
https://doaj.org/article/d1a033da7da847f699478c811b28f10b
Autor:
Aurelie Schwartzentruber, Camilla Boschian, Fernanda Martins Lopes, Monika A. Myszczynska, Elizabeth J. New, Julien Beyrath, Jan Smeitink, Laura Ferraiuolo, Heather Mortiboys
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Mutations in PRKN are the most common cause of early onset Parkinson’s disease. Parkin is an E3 ubiquitin ligase, functioning in mitophagy. Mitochondrial abnormalities are present in PRKN mutant models. Patient derived neurons are a promis
Externí odkaz:
https://doaj.org/article/5d11f9239fc34740ace065b8c2911136
Autor:
André Varcianna, Monika A. Myszczynska, Lydia M. Castelli, Brendan O'Neill, Yeseul Kim, Jordan Talbot, Sophie Nyberg, Immanuelle Nyamali, Paul R. Heath, Matthew J. Stopford, Guillaume M. Hautbergue, Laura Ferraiuolo
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 626-635 (2019)
Background: Astrocytes regulate neuronal function, synaptic formation and maintenance partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) astrocytes display a toxic phenotype that contributes to motor neuron (
Externí odkaz:
https://doaj.org/article/05ea110dca0041249eb8a8d9d78a3cba
Autor:
Tommaso Iannitti, Joseph M. Scarrott, Shibi Likhite, Ian R.P. Coldicott, Katherine E. Lewis, Paul R. Heath, Adrian Higginbottom, Monika A. Myszczynska, Marta Milo, Guillaume M. Hautbergue, Kathrin Meyer, Brian K. Kaspar, Laura Ferraiuolo, Pamela J. Shaw, Mimoun Azzouz
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 75-88 (2018)
Of familial amyotrophic lateral sclerosis (fALS) cases, 20% are caused by mutations in the gene encoding human cytosolic Cu/Zn superoxide dismutase (hSOD1). Efficient translation of the therapeutic potential of RNAi for the treatment of SOD1-ALS pati
Externí odkaz:
https://doaj.org/article/b30506436b9849bf842271b7ed602925
Autor:
Guillaume M. Hautbergue, Lydia M. Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S. Bauer, Jennifer E. Dodd, Monika A. Myszczynska, Sarah M. Alam, Pierre Garneret, Jayanth S. Chandran, Evangelia Karyka, Matthew J. Stopford, Emma F. Smith, Janine Kirby, Kathrin Meyer, Brian K. Kaspar, Adrian M. Isaacs, Sherif F. El-Khamisy, Kurt J. De Vos, Ke Ning, Mimoun Azzouz, Alexander J. Whitworth, Pamela J. Shaw
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
The RNA for ALS- and frontotemporal dementia-associated C9ORF72 gene is exported from nucleus via an unknown mechanism. This study shows that reduction of nuclear export adaptor SRSF1 can alleviate neuronal cell death and nuclear export of C9ORF72 in
Externí odkaz:
https://doaj.org/article/26d01605fb7344faaa67f88fe2c80e8f
Autor:
Laura Ferraiuolo, Joanna D. Holbrook, Richard J. Mead, Poojitha N. Ojamies, Guillaume M. Hautbergue, Alix M. B. Lacoste, Amir Saffari, Monika A Myszczynska, Daniel Neil
Publikováno v:
Nature Reviews Neurology. 16:440-456
Globally, there is a huge unmet need for effective treatments for neurodegenerative diseases. The complexity of the molecular mechanisms underlying neuronal degeneration and the heterogeneity of the patient population present massive challenges to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ab794a6b54c97080ebe897f90c623b
https://doi.org/10.1038/s41582-020-0377-8
https://doi.org/10.1038/s41582-020-0377-8
Autor:
Claire Troakes, Paula Beltran-Lobo, Louisa Johnson, Francesca Tarsitano, Beatriz G. Pérez-Nievas, Maria Jimenez-Sanchez, Irina Vazquez-Villasenor, Laura Ferraiuolo, Martina M. Hughes, Luciana Gammallieri, Wendy Noble, Monika A Myszczynska, Stephen B. Wharton
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Background Pathological interactions between β-amyloid (Aβ) and tau drive synapse loss and cognitive decline in Alzheimer’s disease (AD). Reactive astrocytes, displaying altered functions, are also a prominent feature of AD brain. This large and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39816afd96fdbcc59034e8e0e32ccb10
https://doi.org/10.1186/s12974-021-02371-0
https://doi.org/10.1186/s12974-021-02371-0
Autor:
Paul R. Heath, Laura Ferraiuolo, Luisa Cutillo, Monika A Myszczynska, Ke Ning, Ilaria Granata, Alexander J. Whitworth, Pamela J. Shaw, Lydia M. Castelli, Marta Milo, Matthew R. Livesey, Mario Rosario Guarracino, Ya-Hui Lin, Cleide dos Santos Souza, Guillaume M. Hautbergue, Alvaro Sanchez-Martinez, Mimoun Azzouz
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Funder: Academy of Medical Sciences Springboard Award
Background: Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular
Background: Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24a04993d3be1659b6c4af5f388417e
https://doi.org/10.1186/s13024-021-00475-y
https://doi.org/10.1186/s13024-021-00475-y
Safety and efficacy of C9ORF72-repeat RNA nuclear export inhibition in amyotrophic lateral sclerosis
Autor:
Luisa Cutillo, Paul R. Heath, Alexander J. Whitworth, Laura Ferraiuolo, Dos Santos Souza C, Marta Milo, Lydia M. Castelli, Monika A Myszczynska, Pamela J. Shaw, Mimoun Azzouz, Matthew R. Livesey, Guillaume M. Hautbergue, Ke Ning, Mario Rosario Guarracino, Alvaro Sanchez-Martinez, Ilaria Granata
BackgroundLoss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causing alteration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a06ce4429cd3cb5d7c62d5483308dd
https://doi.org/10.1101/2021.04.12.438950
https://doi.org/10.1101/2021.04.12.438950
