Risk-Adapted Treatment Strategies with Pre-Irradiation Chemotherapy in Pediatric Medulloblastoma: Outcomes from the Polish Pediatric Neuro-Oncology Group

Autor: Marta Perek-Polnik, Anne Cochrane, Jinli Wang, Marzanna Chojnacka, Monika Drogosiewicz, Iwona Filipek, Ewa Swieszkowska, Magdalena Tarasinska, Wiesława Grajkowska, Joanna Trubicka, Paweł Kowalczyk, Bożenna Dembowska-Bagińskai, Mohamed S. Abdelbaki

Publikováno v: Children, Vol 10, Iss 8, p 1387 (2023)

Craniospinal irradiation (CSI) has been a major component of the standard of care treatment backbone for childhood medulloblastoma. However, chemotherapy regimens have varied based on protocol, patient age, and molecular subtyping. In one of the larg

Externí odkaz: https://doaj.org/article/a75953c573114ef189665756af983ec1

The germline variants in DNA repair genes in pediatric medulloblastoma: a challenge for current therapeutic strategies

Autor: Joanna Trubicka, Tomasz Żemojtel, Jochen Hecht, Katarzyna Falana, Dorota Piekutowska- Abramczuk, Rafał Płoski, Marta Perek-Polnik, Monika Drogosiewicz, Wiesława Grajkowska, Elżbieta Ciara, Elżbieta Moszczyńska, Bożenna Dembowska-Bagińska, Danuta Perek, Krystyna H. Chrzanowska, Małgorzata Krajewska-Walasek, Maria Łastowska

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)

Abstract Background The defects in DNA repair genes are potentially linked to development and response to therapy in medulloblastoma. Therefore the purpose of this study was to establish the spectrum and frequency of germline variants in selected DNA

Externí odkaz: https://doaj.org/article/a96162f4796c4a65bf39ef853fbba71b

Nivolumab for the Treatment of Advanced Pediatric Malignancies

Autor: Wojciech MŁynarski, Walentyna Balwierz, Katarzyna PawiŃska-WĄsikowska, Anna Raciborska, Agata MarjaŃska, Mariusz Wysocki, Katarzyna Bobeff, BoŻenna Dembowska-BagiŃska, Agnieszka Mizia-Malarz, Monika Drogosiewicz, Jan StyczyŃski

Publikováno v: Anticancer research. 40(12)

Background/aim Nivolumab is an immune checkpoint inhibitor with high antitumor activity in selected neoplasms. The aim of the study was to evaluate the efficacy and safety of nivolumab in pediatric patients with various types of highly malignant adva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249176a4f4fed5f2e5041997e75e56a2
https://pubmed.ncbi.nlm.nih.gov/33288608

ALK Expression Is a Novel Marker for the WNT-activated Type of Pediatric Medulloblastoma and an Indicator of Good Prognosis for Patients

Autor: Ewa Matyja, Magdalena Tarasińska, Monika Drogosiewicz, Wiesława Grajkowska, Joanna Trubicka, Adam Kretowski, Marta Perek-Polnik, Magdalena Kaleta, Maciej Pronicki, Maria Łastowska, Magdalena Paczkowska-Abdulsalam, Agnieszka Karkucinska-Wieckowska, Bożenna Dembowska-Bagińska, Magdalena Niemira

Publikováno v: ResearcherID

ALK gene rearrangements were identified in a variety of cancers, including neuroblastoma, where the presence of ALK expression is associated with adverse prognosis. ALK mutations have recently been found in the pediatric brain tumor medulloblastoma,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a527a39779bce8f2e16dc7459b8c6d96
https://doi.org/10.1097/pas.0000000000000847

Diagnostics and treatment of diffuse intrinsic pontine glioma : where do we stand?

Autor: Halldora K. Thorarinsdottir, Geert O. Janssens, Ella Kumirova, Sophie E. M. Veldhuijzen van Zanten, Ulrich W. Thomale, Ingrid Torsvik, Virve Pentikäinen, Victor Calvagna, N. Harry Hendrikse, Giedre Rutkauskiene, Veronica Biassoni, Dannis G. van Vuurden, Vicente Santa-Maria Lopez, Fatma E El-Khouly, Maria Joao Gil-da-Costa, Stefan Holm, Simon Bailey, Kaie Pruunsild, Monika Drogosiewicz, Ofelia Cruz-Martinez, Jacques Grill, Gertjan J.L. Kaspers, Maura Massimino, David Sumerauer, Jane Pears, Peter Hauser, Lidija Kitanovski, G. Loizos, Christof M. Kramm, André O. von Bueren, Natacha Entz-Werle, Monica Dragomir, Antonis Kattamis, Karsten Nysom, Tim Hayden, Ladislav Deak, Irene Slavc, Rejin Kebudi, Sandra Jacobs, Enrique López Aguilar, Filip Jadrijevic-Cvrlje

Publikováno v: Journal of Neuro-Oncology, 145(1), 177. Kluwer Academic Publishers
Journal of Neuro-Oncology
Journal of Neuro-Oncology, 145(1), 177-184. Kluwer Academic Publishers
el-Khouly, F E, Veldhuijzen van Zanten, S E M, Santa-Maria Lopez, V, Hendrikse, N H, Kaspers, G J L, Loizos, G, Sumerauer, D, Nysom, K, Pruunsild, K, Pentikainen, V, Thorarinsdottir, H K, Rutkauskiene, G, Calvagna, V, Drogosiewicz, M, Dragomir, M, Deak, L, Kitanovski, L, von Bueren, A O, Kebudi, R, Slavc, I, Jacobs, S, Jadrijevic-Cvrlje, F, Entz-Werle, N, Grill, J, Kattamis, A, Hauser, P, Pears, J, Biassoni, V, Massimino, M, Lopez Aguilar, E, Torsvik, I K, Joao Gil-da-Costa, M, Kumirova, E, Cruz-Martinez, O, Holm, S, Bailey, S, Hayden, T, Thomale, U W, Janssens, G O R, Kramm, C M & van Vuurden, D G 2019, ' Diagnostics and treatment of diffuse intrinsic pontine glioma : where do we stand? ', Journal of Neuro-Oncology, vol. 145, no. 1, pp. 177-184 . https://doi.org/10.1007/s11060-019-03287-9, https://doi.org/10.1007/s11060-019-03287-9
Journal of neuro-oncology, Vol. 145, No 1 (2019) pp. 177-184

Introduction Diffuse intrinsic pontine glioma (DIPG) is a rare clinically, neuro-radiologically, and molecularly defined malignancy of the brainstem with a median overall survival of approximately 11 months. Our aim is to evaluate the current tendenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c4a1c7159536c1bc0c8d610250afc1
https://dspace.library.uu.nl/handle/1874/391428