Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Monika, Budde"'
Distinct genetic liability profiles define clinically relevant patient strata across common diseases
Autor:
Lucia Trastulla, Georgii Dolgalev, Sylvain Moser, Laura T. Jiménez-Barrón, Till F. M. Andlauer, Moritz von Scheidt, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Monika Budde, Urs Heilbronner, Sergi Papiol, Alexander Teumer, Georg Homuth, Henry Völzke, Marcus Dörr, Peter Falkai, Thomas G. Schulze, Julien Gagneur, Francesco Iorio, Bertram Müller-Myhsok, Heribert Schunkert, Michael J. Ziller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient stratification, it remains a major challenge to operationalize complex genetic risk factor p
Externí odkaz:
https://doaj.org/article/00e3ef22c51b4762863b27a5f510cabb
Autor:
Fanny Senner, Lena Hiendl, Susanne Bengesser, Kristina Adorjan, Ion-George Anghelescu, Bernhardt T. Baune, Monika Budde, Udo Dannlowski, Detlef E. Dietrich, Peter Falkai, Andreas J. Fallgatter, Alkomiet Hasan, Maria Heilbronner, Markus Jäger, Georg Juckel, Janos L. Kalman, Carsten Konrad, Mojtaba Oraki Kohshour, Sergi Papiol, Daniela Reich-Erkelenz, Jens Reimer, Sabrina K. Schaupp, Max Schmauß, Simon Senner, Carsten Spitzer, Thomas Vogl, Jörg Zimmermann, Urs Heilbronner, Eva C. Schulte, Thomas G. Schulze, Eva Z. Reininghaus, Sophie-Kathrin Kirchner, Nina Dalkner
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Existing guidelines recommend psychopharmacological treatment for the management of schizophrenia and bipolar disorder as part of holistic treatment concepts. About half of the patients do not take their medication regularly, although treatm
Externí odkaz:
https://doaj.org/article/fed399fc8cce403092c3ddc282f7c12f
Autor:
Mojtaba Oraki Kohshour, Nirmal R. Kannaiyan, August Jernbom Falk, Sergi Papiol, Urs Heilbronner, Monika Budde, Janos L. Kalman, Eva C. Schulte, Marcella Rietschel, Stephanie Witt, Andreas J. Forstner, Stefanie Heilmann-Heimbach, Markus M. Nöthen, Carsten Spitzer, Berend Malchow, Thorsten Müller, Jens Wiltfang, Peter Falkai, Andrea Schmitt, Moritz J. Rossner, Peter Nilsson, Thomas G. Schulze
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract The diagnostic criteria for schizophrenia (SCZ) and bipolar disorder (BD) are based on clinical assessments of symptoms. In this pilot study, we applied high-throughput antibody-based protein profiling to serum samples of healthy controls an
Externí odkaz:
https://doaj.org/article/316001b1b48848e78b45c2177c79da72
Autor:
Fanny Senner, Thomas Schneider-Axmann, Lalit Kaurani, Jörg Zimmermann, Jens Wiltfang, Martin von Hagen, Thomas Vogl, Carsten Spitzer, Simon Senner, Eva C. Schulte, Max Schmauß, Sabrina K. Schaupp, Jens Reimer, Daniela Reich-Erkelenz, Sergi Papiol, Mojtaba Oraki Kohshour, Fabian U. Lang, Carsten Konrad, Sophie-Kathrin Kirchner, Janos L. Kalman, Georg Juckel, Maria Heilbronner, Urs Heilbronner, Christian Figge, Ruth E. Eyl, Detlef Dietrich, Monika Budde, Ion-George Angelescu, Kristina Adorjan, Andrea Schmitt, Andre Fischer, Peter Falkai, Thomas G. Schulze
Publikováno v:
Schizophrenia Research: Cognition, Vol 32, Iss , Pp 100280- (2023)
As core symptoms of schizophrenia, cognitive deficits contribute substantially to poor outcomes. Early life stress (ELS) can negatively affect cognition in patients with schizophrenia and healthy controls, but the exact nature of the mediating factor
Externí odkaz:
https://doaj.org/article/a87a91e89a1743ffb00cde8a9c6b0527
Autor:
Bernadette Wendel, Markus Heidenreich, Monika Budde, Maria Heilbronner, Mojtaba Oraki Kohshour, Sergi Papiol, Peter Falkai, Thomas G. Schulze, Urs Heilbronner, Heike Bickeböller
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
A popular approach to reduce the high dimensionality resulting from genome-wide association studies is to analyze a whole pathway in a single test for association with a phenotype. Kernel machine regression (KMR) is a highly flexible pathway analysis
Externí odkaz:
https://doaj.org/article/ab83f50b8d5948b1a5e2600a3b285a2f
Autor:
Lukasz Smigielski, Sergi Papiol, Anastasia Theodoridou, Karsten Heekeren, Miriam Gerstenberg, Diana Wotruba, Roman Buechler, Per Hoffmann, Stefan Herms, Kristina Adorjan, Heike Anderson-Schmidt, Monika Budde, Ashley L. Comes, Katrin Gade, Maria Heilbronner, Urs Heilbronner, Janos L. Kalman, Farahnaz Klöhn-Saghatolislam, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Christian Figge, Markus Jäger, Georg Juckel, Carsten Konrad, Vanessa Nieratschker, Jens Reimer, Eva Reininghaus, Max Schmauß, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Jörg Zimmermann, Anna Gryaznova, Laura Flatau-Nagel, Markus Reitt, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Fabian U. Lang, Thomas Becker, Moritz E. Wigand, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Till F. M. Andlauer, Wulf Rössler, Susanne Walitza, Peter Falkai, Thomas G. Schulze, Edna Grünblatt
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In thi
Externí odkaz:
https://doaj.org/article/057a8222a0e64555a64d03d86616addf
Autor:
Md Rezaul Islam, Lalit Kaurani, Tea Berulava, Urs Heilbronner, Monika Budde, Tonatiuh Pena Centeno, Vakthang Elerdashvili, Maria‐Patapia Zafieriou, Eva Benito, Sinem M Sertel, Maria Goldberg, Fanny Senner, Janos L Kalman, Susanne Burkhardt, Anne Sophie Oepen, Mohammad Sadman Sakib, Cemil Kerimoglu, Oliver Wirths, Heike Bickeböller, Claudia Bartels, Frederic Brosseron, Katharina Buerger, Nicoleta‐Carmen Cosma, Klaus Fliessbach, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Luca Kleinedam, Christoph Laske, Coraline D Metzger, Matthias H Munk, Robert Perneczky, Oliver Peters, Josef Priller, Boris S. Rauchmann, Nina Roy, Anja Schneider, Annika Spottke, Eike J Spruth, Stefan Teipel, Maike Tscheuschler, Michael Wagner, Jens Wiltfang, Emrah Düzel, Frank Jessen, Delcode Study Group, Silvio O Rizzoli, Wolfram‐Hubertus Zimmermann, Thomas G Schulze, Peter Falkai, Farahnaz Sananbenesi, Andre Fischer
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-28 (2021)
Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced s
Externí odkaz:
https://doaj.org/article/1e2ab5f4a61e40db8cbade9a85f5dc94
Autor:
Bernadette Wendel, Sergi Papiol, Till F. M. Andlauer, Jörg Zimmermann, Jens Wiltfang, Carsten Spitzer, Fanny Senner, Eva C. Schulte, Max Schmauß, Sabrina K. Schaupp, Jonathan Repple, Eva Reininghaus, Jens Reimer, Daniela Reich-Erkelenz, Nils Opel, Igor Nenadić, Susanne Meinert, Carsten Konrad, Farahnaz Klöhn-Saghatolislam, Tilo Kircher, Janos L. Kalman, Georg Juckel, Andreas Jansen, Markus Jäger, Maria Heilbronner, Martin von Hagen, Katrin Gade, Christian Figge, Andreas J. Fallgatter, Detlef E. Dietrich, Udo Dannlowski, Ashley L. Comes, Monika Budde, Bernhard T. Baune, Volker Arolt, Ion-George Anghelescu, Heike Anderson-Schmidt, Kristina Adorjan, Peter Falkai, Thomas G. Schulze, Heike Bickeböller, Urs Heilbronner
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Executive functions are metacognitive capabilities that control and coordinate mental processes. In the transdiagnostic PsyCourse Study, comprising patients of the affective-to-psychotic spectrum and controls, we investigated the genetic bas
Externí odkaz:
https://doaj.org/article/7c0b00512f3e4866ab343f2766142afd
Autor:
Katharina Stahl, Kristina Adorjan, Heike Anderson-Schmidt, Monika Budde, Ashley L. Comes, Katrin Gade, Maria Heilbronner, Janos L. Kalman, Farahnaz Klöhn-Saghatolislam, Mojtaba Oraki Kohshour, Sergi Papiol, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Jens Wiltfang, Eva Reininghaus, Peter Falkai, Thomas G. Schulze, Heike Bickeböller, Urs Heilbronner
Publikováno v:
BJPsych Open, Vol 8 (2022)
Background Case-only longitudinal studies are common in psychiatry. Further, it is assumed that psychiatric ratings and questionnaire results of healthy controls stay stable over foreseeable time ranges. For cognitive tests, improvements over time ar
Externí odkaz:
https://doaj.org/article/c9e25cb4b8a8494b9c355cc8b4b05e41
Autor:
Ashley L. Comes, Darina Czamara, Kristina Adorjan, Heike Anderson-Schmidt, Till F. M. Andlauer, Monika Budde, Katrin Gade, Maria Hake, Janos L. Kalman, Sergi Papiol, Daniela Reich-Erkelenz, Farah Klöhn-Saghatolislam, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Georg Juckel, Max Schmauß, Jörg Zimmermann, Jens Reimer, Eva Reininghaus, Ion-George Anghelescu, Carsten Konrad, Andreas Thiel, Christian Figge, Martin von Hagen, Manfred Koller, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Stephanie H. Witt, Sugirthan Sivalingam, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Jens Wiltfang, Peter Falkai, Thomas G. Schulze, Urs Heilbronner
Publikováno v:
International Journal of Bipolar Disorders, Vol 8, Iss 1, Pp 1-12 (2020)
Abstract Background Stressful life events influence the course of affective disorders, however, the mechanisms by which they bring about phenotypic change are not entirely known. Methods We explored the role of DNA methylation in response to recent s
Externí odkaz:
https://doaj.org/article/d9a20649518a4c5f8f2c241edc22b781