Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Monica Y Lee"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
ObjectiveWe have previously demonstrated the in vivo importance of the Akt-eNOS substrate-kinase relationship, as defective postnatal angiogenesis characteristic of global Akt1-null mice is rescued when bred to ‘gain-of-function’ eNOS S1176D muta
Externí odkaz:
https://doaj.org/article/462e4e5d4bb742a8b1a73d2a5e25656c
Autor:
Jan R. Kraehling, John H. Chidlow, Chitra Rajagopal, Michael G. Sugiyama, Joseph W. Fowler, Monica Y. Lee, Xinbo Zhang, Cristina M. Ramírez, Eon Joo Park, Bo Tao, Keyang Chen, Leena Kuruvilla, Bruno Larriveé, Ewa Folta-Stogniew, Roxana Ola, Noemi Rotllan, Wenping Zhou, Michael W. Nagle, Joachim Herz, Kevin Jon Williams, Anne Eichmann, Warren L. Lee, Carlos Fernández-Hernando, William C. Sessa
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Atherosclerosis is caused by low-density lipoprotein (LDL) buildup in the vessel wall, a process thought to be mediated by LDL receptor alone. Here, the authors show that the endothelium can uptake LDL via ALK1, a TGFβ signalling receptor, suggestin
Externí odkaz:
https://doaj.org/article/745c383654124c2b97ea3d105429cf8d
Publikováno v:
Circulation Research. 131
Recent translational studies have focused on the role of the nuclear pore complexes (NPCs) and its component nucleoporin proteins ( i.e. nucleoporin93 [Nup93]) as potential mediators of cardiovascular disease (CVD). The nuclear pore complex (NPC) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b0e5d7a8be2215a95c53b10130a939a
https://doi.org/10.1161/res.131.suppl_1.p3133
https://doi.org/10.1161/res.131.suppl_1.p3133
ObjectiveWe have previously demonstrated thein vivoimportance of the Akt-eNOS substrate-kinase relationship, as defective postnatal angiogenesis characteristic of global Akt1-null mice is rescued when bred to ‘gain-of-function’ eNOS S1176D mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31fb1038f8131fe96ff4b5cf1cabcab5
https://doi.org/10.1101/2022.01.13.476234
https://doi.org/10.1101/2022.01.13.476234
Autor:
Monica Y. Lee, Michael Simons, William C. Sessa, David J. Vinyard, Ana Gamez-Mendez, Jan R. Kraehling, Themis R. Kyriakides, Gary W. Brudvig, Zhenwu Zhuang, Heino Velazquez, Jiasheng Zhang
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:870-879
Objective— The importance of PI3K/Akt signaling in the vasculature has been demonstrated in several models, as global loss of Akt1 results in impaired postnatal ischemia- and VEGF-induced angiogenesis. The ubiquitous expression of Akt1, however, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87c4a68a050a6abd87fe076558345a8
https://doi.org/10.1161/atvbaha.118.310748
https://doi.org/10.1161/atvbaha.118.310748
Publikováno v:
Journal of Biological Chemistry. 293:973-983
Lipid droplets (LD) are dynamic organelles involved in intracellular lipid metabolism in almost all eukaryotic cells, and LD-associated proteins tightly regulate their dynamics. One LD coat protein is caveolin-1 (Cav-1), an essential component for ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b73e270624ef212690dbf98a2289e6d
https://doi.org/10.1074/jbc.ra117.000980
https://doi.org/10.1074/jbc.ra117.000980
Autor:
Clinton D. Protack, Monica Y. Lee, William C. Sessa, Jan R. Kraehling, Jeans M. Santana, Mo Wang, Toshihiko Isaji, Haidi Hu, Trenton R. Foster, Alan Dardik, Takuya Hashimoto, Hualong Bai, Kota Yamamoto
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports
Low rates of arteriovenous fistula (AVF) maturation prevent optimal fistula use for hemodialysis; however, the mechanism of venous remodeling in the fistula environment is not well understood. We hypothesized that the embryonic venous determinant Eph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e501d6bd6ca72accd30b372d838ddb15
http://link.springer.com/article/10.1038/s41598-017-13071-2
http://link.springer.com/article/10.1038/s41598-017-13071-2
Autor:
Coen van Solingen, Shira Landskroner-Eiger, Maria Quiles del Rey, Yajaira Suárez, Jun Yu, Carlos Fernández-Hernando, William C. Sessa, Mahnaz Sahraei, Marta Fernández-Fuertes, Aranzazu Chamorro-Jorganes, Elisa Araldi, Monica Y. Lee
Publikováno v:
Circulation Research. 118:38-47
Rationale: Several lines of evidence indicate that the regulation of microRNA (miRNA) levels by different stimuli may contribute to the modulation of stimulus-induced responses. The miR-17–92 cluster has been linked to tumor development and angioge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e65829c2844e81934ab519eee67b814
https://doi.org/10.1161/circresaha.115.307408
https://doi.org/10.1161/circresaha.115.307408
Autor:
Kristen L. Leslie, Jing Du, Yingdi Wang, Waiho Tang, Allison C. Ostriker, William C. Sessa, Yi Xie, John Hwa, Xinbo Zhang, Yu Jin, Kathleen A. Martin, Jun Yu, Renjing Liu, Seung Hee Lee, Monica Y. Lee
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 37(12)
Objective— Drug-eluting stent delivery of mTORC1 (mechanistic target of rapamycin complex 1) inhibitors is highly effective in preventing intimal hyperplasia after coronary revascularization, but adverse effects limit their use for systemic vascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2273c6cb63f1c1f00ee283c439770be5
https://pubmed.ncbi.nlm.nih.gov/29025710
https://pubmed.ncbi.nlm.nih.gov/29025710
Autor:
Tara Bancroft, Eric Ackah, Juan Rodriguez-Vita, Manuel Morales-Ruiz, Michael Simons, Themis R. Kyriakides, Monica Y. Lee, Amelia K. Luciano, Anne Eichmann, William C. Sessa
Publikováno v:
Proceedings of the National Academy of Sciences. 111:12865-12870
The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including cell growth, migration, survival, and vascular tone. However, existing literature supports the idea that Akt can be either pro- or antiangiogenic, possibly d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a62bef295476119bbc027f493aa599
https://doi.org/10.1073/pnas.1408472111
https://doi.org/10.1073/pnas.1408472111