Výsledky vyhledávání - "Monica T. Brooks"

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

Autor: Pingwei Li, Cheng Lu, Monica T. Brooks, Roland K. Strong, C. Cheng Kao, Andrew B. Herr, Hengyu Xu, Fuqu Hu, C.T. Ranjith-Kumar, Tim Y. Hou

Publikováno v: Structure. 18(8):1032-1043

RIG-I is a cytosolic sensor of viral RNA that plays crucial roles in the induction of type I interferons. The C-terminal domain (CTD) of RIG-I is responsible for the recognition of viral RNA with 5′ triphosphate (5′ ppp). However, the mechanism o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d67e5a7c80653e532ef04f05e3aaf27

Zobrazit plný text záznamu

The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA

Autor: C.T. Ranjith-Kumar, Monica T. Brooks, Pingwei Li, Srisathiyanarayanan Dharmaiah, Xiaojun Li, C. Cheng Kao, Andrew B. Herr

Publikováno v: Journal of Biological Chemistry. 284:13881-13891

The RIG-I-like receptors (RLRs), RIG-I and MDA5, recognize single-stranded RNA with 5′ triphosphates and double-stranded RNA (dsRNA) to initiate innate antiviral immune responses. LGP2, a homolog of RIG-I and MDA5 that lacks signaling capability, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd14ed2f49d14aef8c22b0da2b4ba3f
https://doi.org/10.1074/jbc.m900818200

Zobrazit plný text záznamu

Convulxin Forms a Dimer in Solution and Can Bind Eight Copies of Glycoprotein VI: Implications for Platelet Activation

Autor: Katsunori Horii, Monica T. Brooks, Andrew B. Herr

Publikováno v: Biochemistry. 48:2907-2914

Convulxin (CVX) is a C-type lectin-like protein from the venom of the South American rattlesnake that functions as a potent agonist of the platelet collagen receptor glycoprotein VI (GPVI). Although CVX is widely used as a platelet agonist, the molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3766b04606d0e5508891a32d502ba0d
https://doi.org/10.1021/bi801820q

Zobrazit plný text záznamu

Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study†

Autor: Milan Tomana, Monica T. Brooks, Hitoshi Suzuki, Michelle M. Gomes, Zina Moldoveanu, Jan Novak, Bruce A. Julian, Jiri Mestecky, Andrew B. Herr

Aberrancies in IgA1 glycosylation have been linked to the pathogenesis of IgA nephropathy (IgAN), a kidney disease characterized by deposits of IgA1-containing immune complexes in the glomerular mesangium. IgA1 from IgAN patients is characterized by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880f3e2382a26564b3e89fe05080d60e
https://europepmc.org/articles/PMC3721678/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání