The UBE2D ubiquitin conjugating enzymes: Potential regulatory hubs in development, disease and evolution

Autor: Monica Roman-Trufero, Niall Dillon

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Ubiquitination of cellular proteins plays critical roles in key signalling pathways and in the regulation of protein turnover in eukaryotic cells. E2 ubiquitin conjugating enzymes function as essential intermediates in ubiquitination reactions by act

Externí odkaz: https://doaj.org/article/450a40788bea43ec905802f98288d0f6

Proline-specific aminopeptidase P prevents replication-associated genome instability.

Autor: Nicola Silva, Maikel Castellano-Pozo, Kenichiro Matsuzaki, Consuelo Barroso, Monica Roman-Trufero, Hannah Craig, Darren R Brooks, R Elwyn Isaac, Simon J Boulton, Enrique Martinez-Perez

Publikováno v: PLoS Genetics, Vol 18, Iss 1, p e1010025 (2022)

Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects of cellular

Externí odkaz: https://doaj.org/article/a96ac9391b0141f5855e9de298dde95f

CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells

Autor: Pierangela Sabbattini, Niall Dillon, Matteo Martufi, Moumita Sarkar, Yi-Fang Wang, Dirk Dormann, Chad Whilding, Monica Roman-Trufero

Publikováno v: Molecular biology of the cell. 32(22)

Mesendoderm cells are key intermediate progenitors that form at the early primitive streak (PrS) and give rise to mesoderm and endoderm in the gastrulating embryo. We have identified an interaction between CNOT3 and the cell cycle kinase Aurora B tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438a24ee2ca0fc4f9ac14df77a0c082a
https://pubmed.ncbi.nlm.nih.gov/34613789

Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs

Autor: Aristeidis Chaidos, Paolo Piazza, Daria Capece, Kevin Blighe, Alexandros P. Siskos, Lucy Penfold, Denise Thiel, Elena López-Jiménez, Martin Kaiser, Valentina S. Caputo, Katarzyna Parzych, Diego A. Oyarzún, Zijing Liu, Hector C. Keun, Guido Franzoso, Ambrosius P. Snijders, Hibah A Al-Sadah, Mauricio Barahona, Anastasios Karadimitris, Vesela Encheva, Paula Saavedra-García, Xiaobei Xiong, Holger W. Auner, Monica Roman-Trufero, Yirun Miao, Marilena Christoforou

Publikováno v: Saavedra-García, P, Roman-Trufero, M, Al-Sadah, H A, Blighe, K, López-Jiménez, E, Christoforou, M, Penfold, L, Capece, D, Xiong, X, Miao, Y, Parzych, K, Caputo, V S, Siskos, A P, Encheva, V, Liu, Z, Thiel, D, Kaiser, M F, Piazza, P, Chaidos, A, Karadimitris, A, Franzoso, G, Snijders, A P, Keun, H C, Oyarzún, D A, Barahona, M & Auner, H W 2021, ' Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 17, e2018229118 . https://doi.org/10.1073/pnas.2018229118
Proceedings of the National Academy of Sciences of the United States of America

Significance Cancer therapies often fail to cure patients because a proportion of tumor cells withstand the toxic effects of chemotherapy. How surviving cancer cells recover from sublethal drug-induced stress is not known, but given that cellular res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ac6903923803fa6b211619ecadade3
http://hdl.handle.net/10044/1/87287

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Autor: Yu Zheng, Peter W. S. Hill, Hakan Bagci, Sriharsa Pradhan, Jolyon Terragni, Vanja Haberle, Monica Roman-Trufero, Malgorzata Borkowska, Cristina E. Requena, Harry G. Leitch, Gopuraja Dharmalingham, Zhiyi Sun, Rachel Amouroux, Romualdas Vaisvila, Boris Lenhard, Sarah Linnett, Petra Hajkova

Publikováno v: Nature

Gametes are highly specialized cells that can give rise to the next generation through their ability to generate a totipotent zygote. In mice, germ cells are first specified in the developing embryo around embryonic day (E) 6.25 as primordial germ ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592748fdda026be29ca886c91a96012c
https://pubmed.ncbi.nlm.nih.gov/29559735