Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Monica R. Langley"'
Autor:
Ha Neui Kim, Monica R. Langley, Whitney L. Simon, Hyesook Yoon, Laurel Kleppe, Ian R. Lanza, Nathan K. LeBrasseur, Aleksey Matveyenko, Isobel A. Scarisbrick
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104934- (2020)
A diet high in fat and sucrose (HFHS), the so-called Western diet promotes metabolic syndrome, a significant co-morbidity for individuals with spinal cord injury (SCI). Here we demonstrate that the spinal cord of mice consuming HFHS expresses reduced
Externí odkaz:
https://doaj.org/article/881bfc9a8a2f4d62ab095bd6e962bda3
Autor:
Richard Gordon, Matthew L. Neal, Jie Luo, Monica R. Langley, Dilshan S. Harischandra, Nikhil Panicker, Adhithiya Charli, Huajun Jin, Vellareddy Anantharam, Trent M. Woodruff, Qun-Yong Zhou, Anumantha G. Kanthasamy, Arthi Kanthasamy
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
Prokineticin-2 (PK2) is a secreted protein involved in a number of physiological functions. Here, the authors find that PK2 expression increases in surviving DA neurons from Parkinson's disease patients, and show it protects against dopaminergic dege
Externí odkaz:
https://doaj.org/article/b8d6e03a18c04bd3a3c79b515e12e20f
Autor:
Claudia F. Lucchinetti, Chan Il Choi, Hyesook Yoon, Monica R. Langley, Isobel A. Scarisbrick, Laurel S. Kleppe, Whitney L. Simon, Claudia C.S. Chini, Eduardo N. Chini, Yong Guo, Thais Peclat
Publikováno v:
The Journal of Neuroscience. 41:8644-8667
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. Increased CD38 expression is present in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination and CD38 is the main nicotinam
Autor:
Souvarish Sarkar, Dilshan S. Harischandra, Anumantha G. Kanthasamy, Huajun Jin, Gregory J. Phillips, Monica R. Langley, Shivani Ghaisas, Gary Zenitsky, Vellareddy Anantharam, Somak Dutta, Bharathi N. Palanisamy, Arthi Kanthasamy, Alexandra Proctor
Publikováno v:
Environmental Health Perspectives
Background: Chronic environmental exposure to manganese (Mn) can cause debilitating damage to the central nervous system. However, its potential toxic effects on the enteric nervous system (ENS) have yet to be assessed. Objective: We examined the eff
Autor:
Huajun Jin, Hariharan Saminathan, Shivani Ghaisas, Manikandan Samidurai, Nikhil Panicker, Valina L. Dawson, Dharmin Rokad, Tae In Kam, Anumantha G. Kanthasamy, Monica R. Langley, Adhithiya Charli, Dilshan S. Harischandra, Arthi Kanthasamy, Olga Pletnikova, Matthew Neal, Souvarish Sarkar, Ted M. Dawson, Vellareddy Anantharam
Publikováno v:
The Journal of Experimental Medicine
Fyn kinase mediates aggregated α-synuclein (αSyn) uptake as well as αSyn-mediated proinflammatory signaling in microglia, leading to NLRP3 inflammasome activation and neuroinflammation in Parkinson’s disease.
Persistent microglia-mediated n
Persistent microglia-mediated n
Autor:
Huajun Jin, Bharathi N. Palanisamy, Monica R. Langley, Anumantha G. Kanthasamy, Shivani Ghaisas, Muhammet Ay, Arthi Kanthasamy, Vellareddy Anantharam
Publikováno v:
Exp Neurol
Mitochondrial dysfunction has been implicated as a key player in the pathogenesis of Parkinson’s disease (PD). The MitoPark mouse, a transgenic mitochondrial impairment model developed by specific inactivation of TFAM in dopaminergic neurons, spont
Autor:
Huajun Jin, Bharathi N. Palanisamy, Muhammet Ay, Anumantha G. Kanthasamy, Shivani Ghaisas, Arthi Kanthasamy, Anantharam, Monica R. Langley
Mitochondrial dysfunction has been implicated as a key player in the pathogenesis of Parkinson’s disease (PD). The MitoPark mouse, a transgenic mitochondrial impairment model developed by specific inactivation of TFAM in dopaminergic neurons, spont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790ed51c441ad27b510d20138f640edc
https://doi.org/10.1101/2020.11.02.365874
https://doi.org/10.1101/2020.11.02.365874
Autor:
Monica R, Langley, Chan-Il, Choi, Thais R, Peclat, Yong, Guo, Whitney L, Simon, Hyesook, Yoon, Laurel, Kleppe, Claudia F, Lucchinetti, Claudia C S, Chini, Eduardo N, Chini, Isobel A, Scarisbrick
Publikováno v:
J Neurosci
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. Increased CD38 expression is present in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination and CD38 is the main nicotinam
Autor:
Jie Luo, Vellareddy Anantharam, Poojya Anantharam, Srikant Rangaraju, Anumantha G. Kanthasamy, Heike Wulff, Dilshan S. Harischandra, Neeraj Kumar Singh, Bharathi N. Palanisamy, Sireesha Manne, Vikrant Singh, Lee-Way Jin, Nikhil Panicker, Hai M. Nguyen, Matthew Neal, Huajun Jin, Muhammet Ay, Dharmin Rokad, Ahmed Abdalla, Souvarish Sarkar, Monica R. Langley, Adhithiya Charli, Emir Malovic, Michelle Gabrielle
Publikováno v:
J Clin Invest
Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson’s disease (PD), and optimal modulation of these targets can provide potential treatments to halt disease
Autor:
Chan-Il Choi, Thais Peclat, Monica R. Langley, Whitney L. Simon, Laurel S. Kleppe, Hyesook Yoon, Claudia C.S. Chini, Eduardo N. Chini, Yong Guo, Claudia F. Lucchinetti, Isobel A. Scarisbrick
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. CD38 has increased expression in the cuprizone and EAE demyelination models and is the main NAD+ depleting enzyme in CNS tissue. Altered NAD+ metabolism h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cb7156efd1556bc2f167c7e993bdf33
https://doi.org/10.1101/2020.06.10.143941
https://doi.org/10.1101/2020.06.10.143941