Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Monica Pomaville"'
Autor:
Siddhi Ramesh, Emma Dyer, Monica Pomaville, Kristina Doytcheva, James Dolezal, Sara Kochanny, Rachel Terhaar, Casey J. Mehrhoff, Kritika Patel, Jacob Brewer, Benjamin Kusswurm, Arlene Naranjo, Hiroyuki Shimada, Nicole A. Cipriani, Aliya N. Husain, Peter Pytel, Elizabeth A. Sokol, Susan L. Cohn, Rani E. George, Alexander T. Pearson, Mark A. Applebaum
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Abstract A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained
Externí odkaz:
https://doaj.org/article/3ee6eb5342a14a0d87b21a668f03f699
Autor:
Monica Pomaville, Mohansrinivas Chennakesavalu, Pingluan Wang, Zhiwei Jiang, Hui-Lung Sun, Peizhe Ren, Ryan Borchert, Varsha Gupta, Chang Ye, Ruiqi Ge, Zhongyu Zhu, Mallory Brodnik, Yuhao Zhong, Kelley Moore, Helen Salwen, Rani E. George, Malgorzata Krajewska, Alexandre Chlenski, Mark A. Applebaum, Chuan He, Susan L. Cohn
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114165- (2024)
Summary: The N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14). High levels
Externí odkaz:
https://doaj.org/article/b70135c60c274c8db78ac7b2b49f0621
Autor:
Malgorzata Krajewska, Ruben Dries, Andrew V. Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L. Greenleaf, Guo-Cheng Yuan, Nathanael S. Gray, Richard A. Young, Matthias Geyer, Scott A. Gerber, Rani E. George
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cdk12 is primarily involved in the regulation of DNA damage response (DDR) gene transcription as well as mRNA processing. Here, the authors demonstrate that CDK12 suppresses intronic polyadenylation, and that inhibition of this kinase primarily affec
Externí odkaz:
https://doaj.org/article/fedbb8762827499baca37a345fd99c5e
Autor:
Nathanael S. Gray, Edmond Chipumuro, Ruben Dries, Guo-Cheng Yuan, Matthias Geyer, Richard A. Young, Arno L. Greenleaf, Yang Gao, Scott A. Gerber, Rani E. George, Tinghu Zhang, Oliver Dodd, Andrew V. Grassetti, Hao Huang, Małgorzata Krajewska, Sofia Dust, Nicholas Kwiatkowski, Bandana Sharma, Monica Pomaville, Daniel S. Day
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR) and mRNA processing. Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741ed814d9ce88c3bc8889aa75745c2a
https://doi.org/10.1101/483958
https://doi.org/10.1101/483958
Autor:
Timothy S. Carey, Jason G. Knott, Raj Lingnurkar, Catherine A. Wilson, Michael Feig, Parimal Kar, David N. Arnosti, Monica Pomaville, Satyaki Sengupta, R. William Henry
The retinoblastoma (RB) tumor suppressor and related family of proteins play critical roles in development through their regulation of genes involved in cell fate. Multiple regulatory pathways impact RB function, including the ubiquitin-proteasome sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb3b14633df37f4aa1cb63fd81941ec
https://europepmc.org/articles/PMC4505513/
https://europepmc.org/articles/PMC4505513/