Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Monica M. Olcina"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The efficacy of radiotherapy, a mainstay of cancer treatment, is strongly influenced by both cellular and non-cellular features of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are a heterogeneous population within the TME and
Externí odkaz:
https://doaj.org/article/61065d8b05cc4ea1b235c5a1bd0287a8
Autor:
Monica M. Olcina, Ryan K. Kim, Nikolas G. Balanis, Caiyun Grace Li, Rie von Eyben, Thomas G. Graeber, Daniel Ricklin, Manuel Stucki, Amato J. Giaccia
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101594- (2020)
Summary: The importance of innate immunity in cancer is increasingly being recognized with recent reports suggesting tumor cell-intrinsic intracellular functions for innate immunity proteins. However, such functions are often poorly understood, and i
Externí odkaz:
https://doaj.org/article/64c2b7db01984770a3fda8aeaa8c2c2f
Autor:
Monica M. Olcina, Nikolas G. Balanis, Ryan K. Kim, B. Arman Aksoy, Julia Kodysh, Michael J. Thompson, Jeff Hammerbacher, Thomas G. Graeber, Amato J. Giaccia
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3721-3732.e6 (2018)
Summary: Complement-mediated cytotoxicity may act as a selective pressure for tumor overexpression of complement regulators. We hypothesize that the same selective pressure could lead to complement alterations at the genetic level. We find that, when
Externí odkaz:
https://doaj.org/article/43f706b039384f6aa667af346e276ebc
Autor:
Enric Domingo, Sahar El Aidy, Gary Hardiman, Carsten Krieg, Lukas M Weber, Bruno Fosso, Marinella Marzano, Monica M Olcina, Khalil Mallah, Mark D Robinson, Silvia Guglietta
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background and aims The role of inflammatory immune responses in colorectal cancer (CRC) development and response to therapy is a matter of intense debate. While inflammation is a known driver of CRC, inflammatory immune infiltrates are a positive pr
Externí odkaz:
https://doaj.org/article/fc97c007bd8c47ffbf5e758117697cc1
SummaryOver the last decade, perspectives on the complement system in the context of cancer have shifted, with complement proteins now implicated in many of the hallmarks of cancer. Systemically, the generation of complement anaphylatoxin C5a, the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f9187705c2f71ffc6b9026e0739285
https://doi.org/10.1038/s41416-022-02116-7
https://doi.org/10.1038/s41416-022-02116-7
Autor:
Amato J. Giaccia, Quynh-Thu Le, Daniel T. Chang, Monica M. Olcina, Caiyun G. Li, Michael S. Binkley, Deana Colburg, Rie von Eyben, Vignesh Viswanathan, Dhanya K. Nambiar, Quaovi H. Sodji
Proportion of various immune cell type in TME of pancreatic cancer (TGCA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f87d4a67ddafdc13b93189ab0a2ffb7
https://doi.org/10.1158/2767-9764.22545558
https://doi.org/10.1158/2767-9764.22545558
Autor:
Amato J. Giaccia, Quynh-Thu Le, Daniel T. Chang, Monica M. Olcina, Caiyun G. Li, Michael S. Binkley, Deana Colburg, Rie von Eyben, Vignesh Viswanathan, Dhanya K. Nambiar, Quaovi H. Sodji
Supplementary Figure S1: Proportion of total NK cell in the tumor microenvironment of 138 pancreatic cancer patients based on the CIBERSORTx analysis of TCGA. Supplementary Figure S2: Immunohistochemical staining of NK cells (Red circle) using NKp46.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9ce888105d74ea970ff4d26bf0cc22
https://doi.org/10.1158/2767-9764.22545561.v1
https://doi.org/10.1158/2767-9764.22545561.v1
Autor:
Amato J. Giaccia, Quynh-Thu Le, Daniel T. Chang, Monica M. Olcina, Caiyun G. Li, Michael S. Binkley, Deana Colburg, Rie von Eyben, Vignesh Viswanathan, Dhanya K. Nambiar, Quaovi H. Sodji
Pancreatic cancer is one of the deadliest cancers, against which current immunotherapy strategies are not effective. Herein, we analyzed the immune cell composition of the tumor microenvironment of pancreatic cancer samples in The Cancer Genome Atlas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817fa32a8cee2e86b420d75e48cc0531
https://doi.org/10.1158/2767-9764.c.6550977
https://doi.org/10.1158/2767-9764.c.6550977
The efficacy of radiotherapy, a mainstay of cancer treatment, is strongly influenced by both cellular and non-cellular features of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are a heterogeneous population within the TME and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaea16164bee93d26f9e48d370fe523
https://ora.ox.ac.uk/objects/uuid:deb3f5cc-c8c5-4eda-b997-859bd2c0cc85
https://ora.ox.ac.uk/objects/uuid:deb3f5cc-c8c5-4eda-b997-859bd2c0cc85
Autor:
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K. Nambiar, Ryan K. Kim, Gabriel N Valbuena, Silvia Guglietta, Carsten Krieg, Damavandi Mahnaz Darvish, Tatsuya Suwa, Alistair Easton, Enric Domingo, Eui Jung Moon, Dadi Jiang, Yanyan Jiang, Albert C Koong, Trent M. Woodruff, Edward E. Graves, Tim Maughan, Simon J. A. Buczacki, Manuel Stucki, Quynh-Thu Le, Simon J. Leedham, Amato J. Giaccia, Monica M Olcina
An immunosuppressive microenvironment causes poor tumour T-cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumours is still a challenge. Using an integrated s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067c11b230c8c3a656c28cd8e2962f11
https://doi.org/10.1101/2023.01.10.521547
https://doi.org/10.1101/2023.01.10.521547