RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy

Autor: Monica Llano-Diez, Wen Fury, Haruka Okamoto, Yu Bai, Jesper Gromada, Lars Larsson

Publikováno v: Skeletal Muscle, Vol 9, Iss 1, Pp 1-12 (2019)

Abstract Background Critical illness myopathy (CIM) is associated with severe skeletal muscle wasting and impaired function in intensive care unit (ICU) patients. The mechanisms underlying CIM remain incompletely understood. To elucidate the biologic

Externí odkaz: https://doaj.org/article/f9a5143b43c64ae5be7cac42781a9b32

Digital PCR quantification of miR-30c and miR-181a as serum biomarkers for Duchenne muscular dystrophy

Autor: Monica Llano-Diez, Carlos Ignacio Ortez, Judit Armas Gay, Lidia Álvarez-Cabado, Cristina Jou, Julita Medina, Andres Nascimento, Cecilia Jimenez-Mallebrera

Publikováno v: Neuromuscular Disorders. 27:15-23

Circulating microRNAs (miRs/miRNAs) are being used as non-invasive biomarkers for diagnosis, prognosis and efficiency of clinical trials. However, to exploit their potential it is necessary to improve and standardize their detection. In a previous st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5793b7c16487e4545fa8761a6d59fb
https://doi.org/10.1016/j.nmd.2016.11.003

The Role of Reactive Oxygen Species in β-Adrenergic Signaling in Cardiomyocytes from Mice with the Metabolic Syndrome

Autor: Jérémy Fauconnier, Johanna T. Lanner, Abram Katz, Jon Sinclair, Daniel C. Andersson, Håkan Westerblad, Shi-Jin Zhang, Mei Zong, Takashi Yamada, Kent Jardemark, Monica Llano-Diez

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167090 (2016)
PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (12), pp.e0167090. ⟨10.1371/journal.pone.0167090⟩
PLoS ONE, 2016, 11 (12), pp.e0167090. ⟨10.1371/journal.pone.0167090⟩

The metabolic syndrome is associated with prolonged stress and hyperactivity of the sympathetic nervous system and afflicted subjects are prone to develop cardiovascular disease. Under normal conditions, the cardiomyocyte response to acute β-adrener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1779165daec3e82e2581271d82559c7a
http://europepmc.org/articles/PMC5131978?pdf=render

Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model

Autor: Lars Larsson, Hanna Göransson, Ann-Marie Gustafson, Monica Llano-Diez, Carl Olsson

Publikováno v: BMC Genomics
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
BMC Genomics, Vol 12, Iss 1, p 602 (2011)
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

Background Acute quadriplegic myopathy (AQM) or critical illness myopathy (CIM) is frequently observed in intensive care unit (ICU) patients. To elucidate duration-dependent effects of the ICU intervention on molecular and functional networks that co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94ee2a94995e51a2cc4175bc5dd0af1
https://doi.org/10.1186/1471-2164-12-602

Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading

Autor: Henrik Engquist, Rebeca Corpeno, Humberto Gonzales Marrero, Konstantin A. Artemenko, Jonas Bergquist, Lars Larsson, Magnus Andersson, Monica Llano-Diez, Nicola Cacciani, Guillaume Renaud

Publikováno v: Critical Care

Introduction Critically ill ICU patients commonly develop severe muscle wasting and impaired muscle function, leading to delayed recovery, with subsequent increased morbidity and financial costs, and decreased quality of life for survivors. Critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9682705d28a540f0e23efb527a6513b1
https://doi.org/10.1186/cc11841