Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials

Autor: Theodore A. Omachi, L. Islam, Claus Bachert, Rui Zhu, Philippe Gevaert, Jonathan Corren, Monica Ligueros-Saylan, Joseph K. Han, Joaquim Mullol, Kit Wong, Ryan Owen, Derrick Kaufman, Monet Howard, Stella E. Lee

Publikováno v: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by IgE hyperproduction and eosinophilic inflammation. The anti-IgE antibody, omalizumab, has demonstrated efficacy in patients with CRSwNP and comorbid asthma previously.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3e33d86c2cb513e3b0ce7dbc8fd072
https://doi.org/10.1016/j.jaci.2020.05.032

Long-term efficacy and safety of omalizumab for nasal polyposis in an open-label extension study

Autor: Joaquim Mullol, Joseph K. Han, Rui Zhao, Kit Wong, Randall A. Ow, Monet Howard, L. Islam, Claus Bachert, Monica Ligueros-Saylan, Theodore A. Omachi, Stella E. Lee, Jonathan Corren, R. Saenz, Philippe Gevaert

Publikováno v: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently remains uncontrolled despite maximal medical therapy and sinonasal surgery, presenting several unmet needs and challenges. Omalizumab previously demonstrated efficacy in CRSwNP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7ee92172abc706b799e8f5c180a8c6
https://doi.org/10.1016/j.jaci.2021.07.045

Omalizumab Improves Outcomes in Patients with Chronic Rhinosinusitis with Nasal Polyps Irrespective of Asthma Status

Autor: Joaquim Mullol, Sanna Toppila-Salmi, Jonathan Corren, Derrick Kaufman, Theodore A. Omachi, Bongin Yoo, Monica Ligueros-Saylan, Monet Howard, Isam Alobid, Joseph K. Han, Randall A. Ow, Kit Wong, Rui Zhu, L. Islam, Claus Bachert, Philippe Gevaert

Publikováno v: Journal of Allergy and Clinical Immunology. 145:AB149

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae6c7bbec3e5605a76fa536693eed2a6
https://doi.org/10.1016/j.jaci.2019.12.480

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

Autor: Paul M Ridker, Jean G MacFadyen, Tom Thuren, Brendan M Everett, Peter Libby, Robert J Glynn, Paul Ridker, Alberto Lorenzatti, Henry Krum, John Varigos, Peter Siostrzonek, Peter Sinnaeve, Francisco Fonseca, Jose Nicolau, Nina Gotcheva, Jacques Genest, Huo Yong, Miguel Urina-Triana, Davor Milicic, Renata Cifkova, Riina Vettus, Wolfgang Koenig, Stephan D Anker, Athanasios J Manolis, Fernando Wyss, Tamas Forster, Axel Sigurdsson, Prem Pais, Alessandro Fucili, Hisao Ogawa, Hiroaki Shimokawa, Irina Veze, Birute Petrauskiene, Leon Salvador, John Kastelein, Jan Hein Cornel, Tor Ole Klemsdal, Felix Medina, Andrzej Budaj, Luminita Vida-Simiti, Zhanna Kobalava, Petar Otasevic, Daniel Pella, Mitja Lainscak, Ki-Bae Seung, Patrick Commerford, Mikael Dellborg, Marc Donath, Juey-Jen Hwang, Hakan Kultursay, Marcus Flather, Christie Ballantyne, Seth Bilazarian, William Chang, Cara East, Brendan Everett, Les Forgosh, Robert Glynn, Barry Harris, Monica Ligueros, Erin Bohula, Bindu Charmarthi, Susan Cheng, Sherry Chou, Jacqueline Danik, Graham McMahon, Bradley Maron, MingMing Ning, Benjamin Olenchock, Reena Pande, Todd Perlstein, Aruna Pradhan, Natalia Rost, Aneesh Singhal, Viviany Taqueti, Nancy Wei, Howard Burris, Angela Cioffi, Anne Marie Dalseg, Nilanjan Ghosh, Julie Gralow, Tina Mayer, Hope Rugo, Vance Fowler, Ajit P Limaye, Sara Cosgrove, Donald Levine, Renato Lopes, John Scott, Robert Hilkert, Georgia Tamesby, Carolyn Mickel, Brian Manning, Julian Woelcke, Monique Tan, Sheryl Manfreda, Tom Ponce, Jane Kam, Ravinder Saini, Kehur Banker, Thomas Salko, Panjat Nandy, Ronda Tawfik, Greg O'Neil, Shobha Manne, Pravin Jirvankar, Shankar Lal, Deepak Nema, Jaison Jose, Rory Collins, Kent Bailey, Roger Blumenthal, Helen Colhoun, Bernard Gersh

Publikováno v: Lancet (London, England). 390(10105)

Inflammation in the tumour microenvironment mediated by interleukin 1β is hypothesised to have a major role in cancer invasiveness, progression, and metastases. We did an additional analysis in the Canakinumab Anti-inflammatory Thrombosis Outcomes S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812cc417728b9562fe3fc374d1a8746d
https://pubmed.ncbi.nlm.nih.gov/30370085

Effects of subcutaneous pasireotide on cardiac repolarization in healthy volunteers: A single‐center, phase I, randomized, four‐way crossover study

Autor: Astrid Breitschaft, Pierre Jordaan, Dongweon Song, Ke Hu, Michelle Hudson, Rashmi Shah, Christelle Darstein, Monica Ligueros-Saylan

Publikováno v: Journal of Clinical Pharmacology

The aim of this study was to evaluate the effects of subcutaneous pasireotide on cardiac repolarization in healthy volunteers. Healthy volunteers were randomized to one of four treatment sequences (n = 112) involving four successive treatments in dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2c766df5349ca195e8cd47b59b4766
https://doi.org/10.1002/jcph.213