Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Monica Leavitt"'
Autor:
David R. Stover, Dennis Benjamin, Pia Challita-Eid, Ingrid B.J. Joseph, Fernando Doñate, Daniel S. Pereira, Ying Li, Jeffrey Coleman, Steven Duniho, Ruth Moser, Faisal Malik, Claudia Guevara, Hector Aviña, Rossana Nadell, Jimmy Ou, Monica Leavitt, Alla Verlinsky, Linnette Capo, Zili An, Karen Morrison, Kendall Morrison, Arthur Raitano, Michael Mattie
Here, we report the development of an antibody–drug conjugate, ASG-5ME, which targets the solute carrier receptor SLC44A4. SLC44A4 is a member of a family of putative choline transporters that we show to be markedly upregulated in a variety of epit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510fb86e62a3f121e464a29893f6e996
https://doi.org/10.1158/1535-7163.c.6538426.v1
https://doi.org/10.1158/1535-7163.c.6538426.v1
Autor:
David R. Stover, Dennis Benjamin, Pia Challita-Eid, Ingrid B.J. Joseph, Fernando Doñate, Daniel S. Pereira, Ying Li, Jeffrey Coleman, Steven Duniho, Ruth Moser, Faisal Malik, Claudia Guevara, Hector Aviña, Rossana Nadell, Jimmy Ou, Monica Leavitt, Alla Verlinsky, Linnette Capo, Zili An, Karen Morrison, Kendall Morrison, Arthur Raitano, Michael Mattie
Figure S1. Proteolytic release of MMAE from ASG-5ME; Figure S2. SLC44A4 RNA expression in normal and tumor specimens from combined Oncomine data sets; Figure S3: Expression of SLC44A4 in OVCAR-5 cells determined by FACS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed5c9b6bfa05d8cb976b95011b8f210
https://doi.org/10.1158/1535-7163.22506523
https://doi.org/10.1158/1535-7163.22506523
Autor:
David R. Stover, Kendall Morrison, Fernando Doñate, Ingrid B.J. Joseph, Daniel S. Pereira, Banmeet S. Anand, Sher Karki, Nick Dinh, Claudia I. Guevara, Hector Aviña, Faisal Malik, Monica Leavitt, Alla Verlinsky, Linnette Capo, Dawn Ratay Lortie, Wendy Liu, Rossana Nadell, Arthur Raitano, Yuriy Shostak, Karen Morrison, Zili An, Peng Yang, Daulet Satpayev, Pia M. Challita-Eid
Figure 1: ADC Localization in tumor xenografts Figure 2: PK profile in mice Table 1: Toxicokinetic parameters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33662d7c8fff2112890631dac24b3b58
https://doi.org/10.1158/0008-5472.22409072
https://doi.org/10.1158/0008-5472.22409072
Autor:
David R. Stover, Kendall Morrison, Fernando Doñate, Ingrid B.J. Joseph, Daniel S. Pereira, Banmeet S. Anand, Sher Karki, Nick Dinh, Claudia I. Guevara, Hector Aviña, Faisal Malik, Monica Leavitt, Alla Verlinsky, Linnette Capo, Dawn Ratay Lortie, Wendy Liu, Rossana Nadell, Arthur Raitano, Yuriy Shostak, Karen Morrison, Zili An, Peng Yang, Daulet Satpayev, Pia M. Challita-Eid
The identification of optimal target antigens on tumor cells is central to the advancement of new antibody-based cancer therapies. We performed suppression subtractive hybridization and identified nectin-4 (PVRL4), a type I transmembrane protein and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb7f9e9e1d2bca30f67a62dabaed0a6
https://doi.org/10.1158/0008-5472.c.6507683
https://doi.org/10.1158/0008-5472.c.6507683
Autor:
Pia M. Challita-Eid, Dawn Ratay Lortie, Daulet Satpayev, Fernando Donate, Yuriy Shostak, Alla Verlinsky, Claudia Guevara, Peng Yang, Banmeet Anand, David R. Stover, Rossana Nadell, Nick Dinh, Zili An, Hector Aviña, Karen Morrison, Ingrid B.J.K. Joseph, Kendall Morrison, Sher Bahadur Karki, Monica Leavitt, Faisal Malik, Wendy Liu, Arthur B. Raitano, Daniel S. Pereira, Linnette Capo
Publikováno v:
Cancer Research. 76:3003-3013
The identification of optimal target antigens on tumor cells is central to the advancement of new antibody-based cancer therapies. We performed suppression subtractive hybridization and identified nectin-4 (PVRL4), a type I transmembrane protein and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868563fe15c4564c7f168742a5b70b58
https://doi.org/10.1158/0008-5472.can-15-1313
https://doi.org/10.1158/0008-5472.can-15-1313
Autor:
Pia M. Challita-Eid, Fernando Donate, Sung-Ju Moon, Joseph D. Abad, Banmeet Anand, René Hubert, Linnette Capo, Chunying Zhang, Brian A. Mendelsohn, Mike Mattie, Baljinder Randhawa, Daniel S. Pereira, Hector Aviña, Nandini Rudra-Ganguly, Alla Verlinsky, Gao Liu, Sher Karki, Mi Sook Chang, Deanna L. Russell, Zili An, Monica Leavitt, Cyrus Virata, David R. Stover, Ingrid B.J.K. Joseph, Christine Lowe, Roland Luethy, Kendall Morrison, Mary Brodey
Publikováno v:
Cancer Research. 76:574-574
FLT3 is a member of the class III receptor tyrosine kinase family that includes C-KIT, C-FMS and platelet derived growth factor receptor (PDGFR). FLT3 is primarily expressed in early myeloid and lymphoid progenitors and plays an important role in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ab046751d3a225ce01905203553641
https://doi.org/10.1158/1538-7445.am2016-574
https://doi.org/10.1158/1538-7445.am2016-574
Autor:
Monica Leavitt, Pia M. Challita-Eid, Christopher Kemball, Liqing Jin, John E. Dick, Chunying Zhang, Gao Liu, Daniel S. Pereira, Michael Mattie, Zili An, Baljinder Randhawa, Hector Aviña, David R. Stover, Joseph D. Abad, Misty Vest, Faisal Malik, Josh Snyder, Brian A. Mendelsohn, Sher Karki, Christine Lowe, Banmeet Anand, Kendall Morrison, Ingrid B.J.K. Joseph, Peng Yang, Cyrus Virata, Nandini Rudra-Ganguly, Deanna L. Russell, Jeanette Grant, René Hubert, Fernando Donate
Publikováno v:
Blood. 126:3806-3806
FLT3 (FMS-like tyrosine kinase 3) is a member of the class III receptor tyrosine kinase family, which is highly expressed in the blasts of both AML and ALL patients. In addition to FL ligand stimulation, FLT3 can also be activated by two distinct clu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b94a09f0818bc29a098c33a93415d7c
https://doi.org/10.1182/blood.v126.23.3806.3806
https://doi.org/10.1182/blood.v126.23.3806.3806
Autor:
Yuriy Shostak, Wendy Liu, Myra Perez, Daulet Satpayev, Peng Yang, Art Raitano, Pia M. Challita-Eid, Zili An, Dawn Ratay Lortie, Karen Morrison, Monica Leavitt, Michael Torgov, Claudia Guevara, Jean M Gudas, David R. Stover, Kendall Morrison, Hector Aviña, Linnette Capo, Alla Verlinsky, Xiao-Chi Jia, Kenna Shirasuna
Publikováno v:
Cancer Research. 71:2832-2832
Nectin-4 is a type I transmembrane antigen identified by Agensys to be highly expressed at the RNA level in a significant number of bladder and breast cancer specimens. Analysis of protein expression carried out in an extensive panel of tumor specime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::870efa31acc4f92477c6a59e99874db2
https://doi.org/10.1158/1538-7445.am2011-2832
https://doi.org/10.1158/1538-7445.am2011-2832