Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Monica L. Fernández-Quintero"'
Autor:
Simone Pelizzari, Martin C. Heiss, Monica L. Fernández-Quintero, Yousra El Ghaleb, Klaus R. Liedl, Petronel Tuluc, Marta Campiglio, Bernhard E. Flucher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Skeletal muscle contractions are initiated by action potentials, which are sensed by the voltage-gated calcium channel (CaV1.1) and are conformationally coupled to calcium release from intracellular stores. Notably, CaV1.1 contains four sepa
Externí odkaz:
https://doaj.org/article/4b3622b2fdfd47c48bbf270c78f4c6df
Autor:
Clarissa A. Seidler, Ricarda Zeindl, Monica L. Fernández-Quintero, Martin Tollinger, Klaus R. Liedl
Publikováno v:
Allergies, Vol 4, Iss 1, Pp 1-16 (2024)
Allergens are substances that cause abnormal immune responses and can originate from various sources. IgE-mediated allergies are one of the most common and severe types of allergies, affecting more than 20% of the population in Western countries. All
Externí odkaz:
https://doaj.org/article/c72f941c8a144f5d931f280e354894b0
Autor:
Thomas Heigl, Michael A. Netzer, Lucia Zanetti, Matthias Ganglberger, Monica L. Fernández-Quintero, Alexandra Koschak
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTCav1.4 L-type calcium channels are predominantly expressed at the photoreceptor terminals and in bipolar cells, mediating neurotransmitter release. Mutations in its gene, CACNA1F, can cause congenital stationary night-blindness type 2 (CSNB2)
Externí odkaz:
https://doaj.org/article/ef2b99a0abab4d838bb79811b9811fd5
Autor:
Monica L. Fernández-Quintero, Anne Ljungars, Franz Waibl, Victor Greiff, Jan Terje Andersen, Torleif T. Gjølberg, Timothy P. Jenkins, Bjørn Gunnar Voldborg, Lise Marie Grav, Sandeep Kumar, Guy Georges, Hubert Kettenberger, Klaus R. Liedl, Peter M. Tessier, John McCafferty, Andreas H. Laustsen
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBeyond potency, a good developability profile is a key attribute of a biological drug. Selecting and screening for such attributes early in the drug development process can save resources and avoid costly late-stage failures. Here, we review
Externí odkaz:
https://doaj.org/article/40e1d35a06264ee9a178e72c2e9b24b1
Autor:
Monica L. Fernández-Quintero, Janik Kokot, Franz Waibl, Anna-Lena M. Fischer, Patrick K. Quoika, Charlotte M. Deane, Klaus R. Liedl
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAdvances in structural biology and the exponential increase in the amount of high-quality experimental structural data available in the Protein Data Bank has motivated numerous studies to tackle the grand challenge of predicting protein struc
Externí odkaz:
https://doaj.org/article/3a42b424031444ed92eeaed275b5f9d3
Autor:
Gregory M. Martin, Monica L. Fernández-Quintero, Wen-Hsin Lee, Tossapol Pholcharee, Lisa Eshun-Wilson, Klaus R. Liedl, Marie Pancera, Robert A. Seder, Ian A. Wilson, Andrew B. Ward
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract A primary objective in malaria vaccine design is the generation of high-quality antibody responses against the circumsporozoite protein of the malaria parasite, Plasmodium falciparum (PfCSP). To enable rational antigen design, we solved a cr
Externí odkaz:
https://doaj.org/article/81b612e0dd0843d08f8980ba7b082600
Autor:
Ricarda Zeindl, Annika L. Franzmann, Monica L. Fernández-Quintero, Clarissa A. Seidler, Valentin J. Hoerschinger, Klaus R. Liedl, Martin Tollinger
Publikováno v:
Foods, Vol 12, Iss 21, p 3939 (2023)
Allergies related to kiwi consumption have become a growing health concern, with their prevalence on the rise. Many of these allergic reactions are attributed to cross-reactivity, particularly with the major allergen found in birch pollen. This cross
Externí odkaz:
https://doaj.org/article/fe1e1fd7776e4973b30f55bece410676
Autor:
Monica L. Fernández-Quintero, Nancy D. Pomarici, Anna-Lena M. Fischer, Valentin J. Hoerschinger, Katharina B. Kroell, Jakob R. Riccabona, Anna S. Kamenik, Johannes R. Loeffler, James A. Ferguson, Hailee R. Perrett, Klaus R. Liedl, Julianna Han, Andrew B. Ward
Publikováno v:
Antibodies, Vol 12, Iss 4, p 67 (2023)
Antibodies and other new antibody-like formats have emerged as one of the most rapidly growing classes of biotherapeutic proteins. Understanding the structural features that drive antibody function and, consequently, their molecular recognition is cr
Externí odkaz:
https://doaj.org/article/ebfea549dcaf49caafa4ea894542b32c
Autor:
Patrick K. Quoika, Anna S. Kamenik, Monica L. Fernández-Quintero, Martin Zacharias, Klaus R. Liedl
Publikováno v:
Frontiers in Materials, Vol 10 (2023)
Poly (N-isopropylacrylamide) (PNIPAM) is a famous representative of thermosensitive polymers. Thermosensitive polymers undergo a phase transition with lower critical solution temperature. Commonly, their phase behavior is linked to a conformational c
Externí odkaz:
https://doaj.org/article/277199a959b6451a8d6256f866c0fca0
Autor:
Monica L. Fernández-Quintero, Katharina B. Kroell, Lukas J. Grunewald, Anna-Lena M. Fischer, Jakob R. Riccabona, Klaus R. Liedl
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies, is critical to the advancement of the field. In contrast to monovalent antibodies, which consist of two identical a
Externí odkaz:
https://doaj.org/article/41ed716d49394237ba3a58d51752e8d4